Glenn C. Rodrigo
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Signalling pathways involved in urotensin II induced ventricular myocyte hypertrophy Open
Sustained pathologic myocardial hypertrophy can result in heart failure(HF); a significant health issue affecting a large section of the population worldwide. In HF there is a marked elevation in circulating levels of the peptide urotensin…
Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection Open
Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantita…
Daily remote ischaemic conditioning following acute myocardial infarction: a randomised controlled trial Open
Background Remote ischaemic conditioning (rIC) is a cardioprotective tool which has shown promise in preclinical and clinical trials in the context of acute ischaemia. Repeated rIC post myocardial infarction may provide additional benefits…
184 Urotensin ii induces cardiomyocytes hypertrophy via activation of the mapk and camkii signalling pathways Open
Introduction The normal concentration of circulating Urotensin II (UII) is elevated in heart failure (Ng et al. 2002). UII has been shown to be involved the development of pathological cardiac hypertrophy (Tzanidis et al. 2003). The aim of…
Time‐of‐day variation in vascular function Open
New Findings What is the topic of this review? This report looks at the role of endothelial nitric oxide signalling in the time‐of‐day variation in vasoconstriction of resistance vessels. What advances does it highlight? It highlights a ti…