James Law
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View article: AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis
AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis Open
Liver fibrosis has few treatment options due to the poor quality of the available animal and in vitro models. To address this, a hypothesis generating multi‐agent AI system (AI co‐scientist) is used to assist in re‐purposing drugs for trea…
View article: AI-assisted Drug Re-purposing for Human Liver Fibrosis
AI-assisted Drug Re-purposing for Human Liver Fibrosis Open
Liver fibrosis is a severe disease with few treatment options due to the poor quality of the available animal and in vitro models. To address this, we investigated whether a hypothesis generating multi-agent AI system (AI co-scientist) cou…
View article: Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components
Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components Open
Background Women who have additional social and care needs in pregnancy (e.g. social adversity, maternal depression and anxiety) are likely to produce high levels of stress hormones. This has the potential to affect fetal brain development…
View article: UK paediatric speech and language therapists’ perceptions on the use of telehealth in current and future clinical practice: An application of the APEASE criteria
UK paediatric speech and language therapists’ perceptions on the use of telehealth in current and future clinical practice: An application of the APEASE criteria Open
Background Telehealth for paediatric speech and language therapy became one of the most salient modes of service delivery during the COVID‐19 pandemic. Evidence for speech and language therapy services via telehealth in comparison to face‐…
View article: Screening for Language Difficulties in Disadvantaged Populations on Entry to Early Years Education: Challenges and Opportunities
Screening for Language Difficulties in Disadvantaged Populations on Entry to Early Years Education: Challenges and Opportunities Open
Children aged 3–4 years ( n = 876) were recruited from deprived areas in England, and a significant minority of the sample were second language learners. Oral language ability was assessed using child administered standardized measures, an…
View article: Double advantage of parental education for child educational achievement: the role of parenting and child intelligence
Double advantage of parental education for child educational achievement: the role of parenting and child intelligence Open
Background Parental education is one of the best predictors of child school achievement. Higher parental education is not only associated with higher child intelligence, but children from highly educated parents also perform better in scho…
View article: The Emergence of 5-Year-Olds’ Behavioral Difficulties: Analyzing Risk and Protective Pathways in the United Kingdom and Germany
The Emergence of 5-Year-Olds’ Behavioral Difficulties: Analyzing Risk and Protective Pathways in the United Kingdom and Germany Open
This study aimed to advance our understanding of 5-year-olds’ behavioral difficulties by modeling and testing both mediational protective and risk pathways simultaneously. Drawing on two national samples from different Western European cou…
View article: Universal language development screening: comparative performance of two questionnaires
Universal language development screening: comparative performance of two questionnaires Open
Background and objective Low language ability in early childhood is a strong predictor of later psychopathology as well as reduced school readiness, lower educational attainment, employment problems and involvement with the criminal justic…
View article: Allocation and funding of Speech and Language Therapy for children with Developmental Language Disorders across Europe and beyond
Allocation and funding of Speech and Language Therapy for children with Developmental Language Disorders across Europe and beyond Open
The results implies that other factors than evidence-based practices, practitioners experience, and patient preferences, drive choices in therapy. More research is needed to gain a better understanding of factors affecting the choice of th…
View article: The Role of Social and Emotional Adjustment in Mediating the Relationship Between Early Experiences and Different Language Outcomes
The Role of Social and Emotional Adjustment in Mediating the Relationship Between Early Experiences and Different Language Outcomes Open
Background: Studies have highlighted the relationship between early childhood experiences and later language and communication skills on the one hand and social and emotional adjustment on the other. Less is known about this relationship b…
View article: ‘Making the Most of Together-Time’: Development of a Health Visitor Led Intervention to Support Children’s Early Language and Communication Development at the 2-2½ Year-Old Review
‘Making the Most of Together-Time’: Development of a Health Visitor Led Intervention to Support Children’s Early Language and Communication Development at the 2-2½ Year-Old Review Open
Background: Early interventions to support young children’s language development through responsive parent-child interaction have proven efficacy but are not currently delivered universally. A potential universal delivery platform is the H…
View article: Tele‐practice for children and young people with communication disabilities: Employing the COM‐B model to review the intervention literature and inform guidance for practitioners
Tele‐practice for children and young people with communication disabilities: Employing the COM‐B model to review the intervention literature and inform guidance for practitioners Open
Background Many healthcare and educational services providers have undergone a rapid transition from a face‐to‐face to a tele‐practice mode of service delivery in the context of the COVID‐19 outbreak. This, in turn, has led to a need to un…
View article: Variation in headteachers' approaches to meeting the needs of primary school children with speech, language and communication needs (SLCN) in one English Local Authority: a systems approach
Variation in headteachers' approaches to meeting the needs of primary school children with speech, language and communication needs (SLCN) in one English Local Authority: a systems approach Open
Background Recent large-scale research in England has reported lack of equity in the school services and support received by children with speech, language and communication needs (SLCN), even in schools in similar demographic areas. How h…
View article: The Emergence of Inner Speech and Its Measurement in Atypically Developing Children
The Emergence of Inner Speech and Its Measurement in Atypically Developing Children Open
Inner speech (IS), or the act of silently talking to yourself, occurs in humans regardless of their cultural and linguistic background, suggesting its key role in human cognition. The absence of overt articulation leads to methodological c…
View article: Supplementary Material for: Cultural and Linguistic Practice with Children with Developmental Language Disorder: Findings from an International Practitioner Survey
Supplementary Material for: Cultural and Linguistic Practice with Children with Developmental Language Disorder: Findings from an International Practitioner Survey Open
Background: The cultural and language diversity across many European countries presents a range of challenges and opportunities for speech and language therapists and other practitioners working with children with developmental language di…
View article: Correction to: Trial of healthy relationship initiatives for the very early years (THRIVE), evaluating Enhanced Triple P for Baby and Mellow Bumps for those with additional social and care needs during pregnancy and their infants who are at higher risk of maltreatment: study protocol for a randomised controlled trial
Correction to: Trial of healthy relationship initiatives for the very early years (THRIVE), evaluating Enhanced Triple P for Baby and Mellow Bumps for those with additional social and care needs during pregnancy and their infants who are at higher risk of maltreatment: study protocol for a randomised controlled trial Open
Following publication of the original article [1], it has been brought to our attention that an error was slipped into the article’s title.
View article: Training community health nurses to measure parent–child interaction: a mixed-methods study
Training community health nurses to measure parent–child interaction: a mixed-methods study Open
Background This study aims to determine whether the Parental Responsiveness Rating Scale (PaRRiS) completed at child age 24–30 months can be used by community child health nurses (CCHNs) to reliably measure the quality of parent–child inte…
View article: Teachers observing classroom communication: An application of the Communicating Supporting Classroom Observation Tool for children aged 4–7 years
Teachers observing classroom communication: An application of the Communicating Supporting Classroom Observation Tool for children aged 4–7 years Open
The nature of ‘Teacher talk’ is likely to have a considerable bearing on the child’s learning but measuring the communication environment in the classroom can present challenges. One tool which does this is the Communication Supporting Cla…
View article: Preschool developmental concerns and adjustment in the early school years: Evidence from a Scottish birth cohort
Preschool developmental concerns and adjustment in the early school years: Evidence from a Scottish birth cohort Open
Background Preschool language and behavioural difficulties impact on multiple domains of the child's early life and can endure into adulthood, predicting poor educational, social, and health outcomes. Highlighting risk factors associated w…
View article: The Changing Perception of Communication Needs—A Litmus Test for the Warnock Legacy
The Changing Perception of Communication Needs—A Litmus Test for the Warnock Legacy Open
Meeting Lady Warnock1 at the final conference for some work commissioned by the DfEE/NHS in 2001, she said that one of her greatest concerns about her earlier report is the fetishisation of the statement of education needs. It was, of cour…
View article: Vocabulary Development and Trajectories of Behavioral and Emotional Difficulties Via Academic Ability and Peer Problems
Vocabulary Development and Trajectories of Behavioral and Emotional Difficulties Via Academic Ability and Peer Problems Open
This study investigates associations between trajectories of children's vocabulary development and subsequent behavioral and emotional difficulties via two potential mediating mechanisms; literacy and peer problems. Nationally representati…
View article: Population woods and clinical trees. A commentary on ‘Evidence‐based pathways to intervention for children with language disorders’
Population woods and clinical trees. A commentary on ‘Evidence‐based pathways to intervention for children with language disorders’ Open
The number of good‐quality intervention studies (randomized controlled trials) has more than doubled since the 2003 Cochrane Review (Law et al. 2003), and it is important to reflect on the conclusions that can be drawn from such reviews. C…
View article: Developmental Language Disorder
Developmental Language Disorder Open
This chapter describes the history of research in Language Disorders (LD) outlining changes in terminology and methodology and focuses on three newer research methodologies: population studies, the characterization of longitudinal change, …
View article: Parent-child reading to improve language development and school readiness: A systematic review and meta-analysis (Final report)
Parent-child reading to improve language development and school readiness: A systematic review and meta-analysis (Final report) Open
Item also deposited in University of Newcastle repository (21 July 2018) at: https://eprints.ncl.ac.uk/246226