Christopher J. Brackman
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View article: The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues Open
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses has been accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle. To evalu…
View article: Rapidly Progressing Melioidosis Outbreak in City Center Zoo, Hong Kong, 2024
Rapidly Progressing Melioidosis Outbreak in City Center Zoo, Hong Kong, 2024 Open
In October 2024, twelve primates from 4 species died of sepsis at the Hong Kong Zoological and Botanical Gardens. Postmortem examinations and microbiological analyses confirmed Burkholderia pseudomallei infection. Phylogenetic analysis rev…
View article: The First African Swine Fever Viruses Detected in Wild Boar in Hong Kong, 2021–2023
The First African Swine Fever Viruses Detected in Wild Boar in Hong Kong, 2021–2023 Open
This study represents the first report on the detection and whole-genome sequencing of African swine fever (ASF) viruses in wild boar in Hong Kong in 2021–2023. Wild boar samples collected via an ASF surveillance program by the Agriculture…
View article: The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues
The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues Open
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses is accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle. To evaluate if…
View article: Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024
Detection and characterisation of high pathogenicity avian influenza virus (H5N1/H5N8) clade 2.3.4.4b, Hong Kong SAR, China, 2021 to 2024 Open
We isolated three genotypes of highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b from wild birds infected with H5N1 (n = 12) and H5N8 (n = 1) in Hong Kong SAR 2021–2024. Viruses from two spoonbills from late 2022 were genetica…
View article: Surveillance of coronaviruses in wild aquatic birds in Hong Kong: expanded genetic diversity and discovery of novel subgenus in the <i>Deltacoronavirus</i>
Surveillance of coronaviruses in wild aquatic birds in Hong Kong: expanded genetic diversity and discovery of novel subgenus in the <i>Deltacoronavirus</i> Open
Migratory birds may carry emerging viruses over long distances. Regular surveillance and metagenomic analysis were employed to explore the diversity of avian coronaviruses at Hong Kong’s Mai Po Wetland. We tested a total of 3239 samples co…
View article: Rosette-forming multicentric B-cell lymphoma in a giant panda
Rosette-forming multicentric B-cell lymphoma in a giant panda Open
Literature covering diseases of the giant panda ( Ailuropoda melanoleuca) is either in Chinese or focuses on infectious agents. Here we describe the clinical signs, gross and microscopic findings, and immunohistochemistry results of a B-ce…
View article: Investigation of the First African Swine Fever Outbreak in a Domestic Pig Farm in Hong Kong
Investigation of the First African Swine Fever Outbreak in a Domestic Pig Farm in Hong Kong Open
In this study, we describe the epidemiological investigation of the first African swine fever (ASF) outbreak in a local domestic pig farm in the New Territories of Hong Kong in 2021. In the outbreak farm, several affected pigs presented cl…
View article: Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea
Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. Knowing the potential capacity of the virus to adapt to other species, the serological surveillance of SARS…
View article: Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the Covid-19 Pandemic in Hong Kong and Korea
Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the Covid-19 Pandemic in Hong Kong and Korea Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. The current global pandemic was driven by human-to-human transmission. Knowing the zoonotic origin of the d…
View article: Novel Zoonotic Avian Influenza Virus A(H3N8) Virus in Chicken, Hong Kong, China
Novel Zoonotic Avian Influenza Virus A(H3N8) Virus in Chicken, Hong Kong, China Open
Zoonotic and pandemic influenza continue to pose threats to global public health. Pandemics arise when novel influenza A viruses, derived in whole or in part from animal or avian influenza viruses, adapt to transmit efficiently in a human …
View article: A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong
A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong Open
Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high importance for farmers and policy makers in Asia. In October 2020, feral cattle in Hon…
View article: A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong
A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong Open
Summary Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that is currently spreading throughout Asia. The disease situation is of high importance for farmers and policy makers in Asia. In October 2020, feral cattl…
View article: Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera
Evaluation of a SARS-CoV-2 Surrogate Virus Neutralization Test for Detection of Antibody in Human, Canine, Cat, and Hamster Sera Open
Surrogate neutralization assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be done without biosafety level 3 containment and in multiple species are desirable. We evaluate a recently developed surrogate virus…
View article: SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China
SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China Open
We tested 50 cats from coronavirus disease households or close contacts in Hong Kong, China, for severe acute respiratory syndrome coronavirus 2 RNA in respiratory and fecal samples. We found 6 cases of apparent human-to-feline transmissio…
View article: Evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in human, canine, cat and hamster sera
Evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in human, canine, cat and hamster sera Open
Surrogate neutralization assays for SARS-CoV-2 that can be done without biosafety-level-3 containment and across multiple species are desirable. We evaluate a recently developed surrogate virus neutralization test (sVNT) in comparison to 9…
View article: Canine SARS-CoV-2 infection
Canine SARS-CoV-2 infection Open
SARS-CoV-2 emerged in Wuhan in December 2019 and has caused the pandemic respiratory disease, COVID-19. Following what is presumed to be an initial zoonotic transmission event, the virus is now spreading efficient in humans. Very little is…
View article: An evaluation of vaccination in poultry as an intervention strategy for control of H5N1 avian influenza infection
An evaluation of vaccination in poultry as an intervention strategy for control of H5N1 avian influenza infection Open
Background
\nH5N1 highly pathogenic avian influenza (HPAI) continues to be a serious threat to human and animal health with upwards of 840 human infections and 447 deaths since 2003. It also has pandemic potential. Vaccination in poultry …