Chris JD Hardy
YOU?
Author Swipe
View article: Correction: Hearing impairment and dementia: cause, catalyst or consequence?
Correction: Hearing impairment and dementia: cause, catalyst or consequence? Open
View article: The emotional journey through the stages of primary progressive aphasia: seven co-produced care pathway recommendations for clinical practice
The emotional journey through the stages of primary progressive aphasia: seven co-produced care pathway recommendations for clinical practice Open
Primary progressive aphasia (PPA) describes a group of language-led dementias associated with frontotemporal dementia and Alzheimer’s disease. Speech and language therapy is the main intervention for PPA. Yet, there remains little guidance…
View article: Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes
Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes Open
AAS perception stratifies FTD syndromes and constitutes a "real-world audiogram" in these diseases.
View article: Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis Open
Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not clear. In this systematic review and meta-analysis, we evaluated associations between hear…
View article: Perimortem caesarean section in the pre-hospital setting: a case report and suggested changes to guidelines
Perimortem caesarean section in the pre-hospital setting: a case report and suggested changes to guidelines Open
View article: Decline in activities of daily living in the rarer dementias
Decline in activities of daily living in the rarer dementias Open
Rarer dementias are associated with atypical symptoms and younger onset, which result in a higher burden of care. We provide a review of the global literature on longitudinal decline in activities of daily living (ADLs) in dementias that a…
View article: Hearing impairment and dementia: cause, catalyst or consequence?
Hearing impairment and dementia: cause, catalyst or consequence? Open
The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this l…
View article: Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia
Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia Open
Previous research suggests that emotional prosody perception is impaired in neurodegenerative diseases like Alzheimer’s disease (AD) and primary progressive aphasia (PPA). However, no previous research has investigated emotional prosody pe…
View article: Auditory processing deficits in subacute stroke
Auditory processing deficits in subacute stroke Open
View article: Primary progressive aphasia in Italian and English: a cross‐linguistic cohort study
Primary progressive aphasia in Italian and English: a cross‐linguistic cohort study Open
Background Primary Progressive Aphasia (PPA) is a neurodegenerative disorder primarily affecting language abilities, with clinical variants (nonfluent/agrammatic variant [nfvPPA], semantic variant [svPPA], logopenic variant [lvPPA], and mi…
View article: Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta‐analysis
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta‐analysis Open
Background Various explanations have been proposed for how hearing impairment might be associated with increased risk of dementia. Several theories have proposed direct links with Alzheimer’s disease (AD) neuropathology, either due to shar…
View article: The auditory phenotype of behavioural variant and right temporal variant frontotemporal dementia
The auditory phenotype of behavioural variant and right temporal variant frontotemporal dementia Open
Background Patients with behavioural variant frontotemporal dementia (bvFTD) and right temporal variant frontotemporal dementia (rtvFTD) commonly exhibit abnormal hedonic and other behavioural responses to sounds, however hearing dysfuncti…
View article: Dysphagia in primary progressive aphasia: clinical predictors and neuroanatomical basis
Dysphagia in primary progressive aphasia: clinical predictors and neuroanatomical basis Open
Background Dysphagia is an important feature of neurodegenerative diseases and potentially life‐threatening in primary progressive aphasia (PPA), but remains poorly characterised in these syndromes. We hypothesised that dysphagia would be …
View article: The dynamics of auditory working memory impairment in logopenic variant primary progressive aphasia and typical Alzheimer’s disease
The dynamics of auditory working memory impairment in logopenic variant primary progressive aphasia and typical Alzheimer’s disease Open
Background Impaired auditory verbal working memory is a diagnostic hallmark and integral driver of the clinical phenotype in logopenic variant primary progressive aphasia (lvPPA). However, the physiology of the working memory buffer in thi…
View article: An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings Open
INTRODUCTION: Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have re…
View article: Primary Progressive Aphasia in Italian and English
Primary Progressive Aphasia in Italian and English Open
Language-specific characteristics influenced PPA phenotypes, with more frequent expressive agrammatism in Italian (reflecting its morphologic complexity), more frequently impaired word processing in English (reflecting its articulatory, ac…
View article: An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings Open
INTRODUCTION Interventions to treat speech‐language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of importance to people with PPA that have rec…
View article: Preserved musical working memory and absolute pitch in posterior cortical atrophy
Preserved musical working memory and absolute pitch in posterior cortical atrophy Open
Working memory for nonverbal auditory information is essential for everyday functioning but its cognitive organisation is not well understood. Here we addressed this issue in a musician, YA, with absolute pitch (AP, the uncommon ability to…
View article: Data-driven neuroanatomical subtypes of primary progressive aphasia
Data-driven neuroanatomical subtypes of primary progressive aphasia Open
The primary progressive aphasias are rare, language-led dementias, with three main variants: semantic, non-fluent/agrammatic and logopenic. Although the semantic variant has a clear neuroanatomical profile, the non-fluent/agrammatic and lo…
View article: Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease
Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease Open
Hearing is multifaceted, and the relative contributions of peripheral and central hearing loss are rarely considered together in the context of dementia. Here, we assessed peripheral (as measured with pure-tone audiometry) and central (as …
View article: Inappropriate trusting behaviour in dementia
Inappropriate trusting behaviour in dementia Open
Background Inappropriate trusting behaviour may have significant social, financial and other consequences for people living with dementia. However, its clinical associations and predictors have not been clarified. Here we addressed this is…
View article: Dysphagia in primary progressive aphasia: Clinical predictors and neuroanatomical basis
Dysphagia in primary progressive aphasia: Clinical predictors and neuroanatomical basis Open
Background and purpose Dysphagia is an important feature of neurodegenerative diseases and potentially life‐threatening in primary progressive aphasia (PPA) but remains poorly characterized in these syndromes. We hypothesized that dysphagi…
View article: Data-driven neuroanatomical subtypes of primary progressive aphasia
Data-driven neuroanatomical subtypes of primary progressive aphasia Open
The primary progressive aphasias are rare, language-led dementias, with three main variants: semantic, non-fluent/agrammatic, and logopenic. Whilst semantic variant has a clear neuroanatomical profile, the non-fluent/agrammatic and logopen…
View article: COS-PPA: protocol to develop a core outcome set for primary progressive aphasia
COS-PPA: protocol to develop a core outcome set for primary progressive aphasia Open
Introduction The term primary progressive aphasia (PPA) describes a group of language-led dementias. Disease-modifying treatments that delay, slow or reverse progression of PPA are currently lacking, though a number of interventions to man…
View article: Symptom‐based staging for logopenic variant primary progressive aphasia
Symptom‐based staging for logopenic variant primary progressive aphasia Open
Background and purpose Logopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction across AD phenotypes. A clinical staging syst…
View article: Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change
Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change Open
Background Hearing loss has been proposed as a modifiable risk factor for dementia. However, the relationship between hearing, neurodegeneration, and cognitive change, and the extent to which pathological processes such as Alzheimer’s dise…
View article: Primary progressive aphasia in Italian and English: a cross-linguistic cohort study
Primary progressive aphasia in Italian and English: a cross-linguistic cohort study Open
Background and objectives Primary progressive aphasia (PPA) signifies a diverse group of neurodegenerative disorders principally affecting language functions. The major syndromic variants of PPA present with distinct profiles of linguistic…
View article: Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease
Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease Open
Hearing is multifaceted and the relative contributions of peripheral and central hearing loss are rarely considered together in the context of dementia. Here, we assessed peripheral (as measured with pure-tone audiometry) and central (as m…
View article: ‘Communication is difficult’: Speech, language and communication needs of people with young onset or rarer forms of non‐language led dementia
‘Communication is difficult’: Speech, language and communication needs of people with young onset or rarer forms of non‐language led dementia Open
Background People with behavioural variant frontotemporal dementia, Lewy body dementia, posterior cortical atrophy and young onset Alzheimer's disease may experience language and communication difficulties. However, the role of speech and …
View article: How Do Care Partners of People with Rare Dementia Use Language in Online Peer Support Groups? A Quantitative Text Analysis Study
How Do Care Partners of People with Rare Dementia Use Language in Online Peer Support Groups? A Quantitative Text Analysis Study Open
We used quantitative text analysis to examine conversations in a series of online support groups attended by care partners of people living with rare dementias (PLWRD). We used transcripts of 14 sessions (>100,000 words) to explore pattern…