Christopher J. L. Newth
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View article: Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation
Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation Open
Objective To independently validate an empirically optimized algorithm for calculating estimated Oxygenation Index (eOI) using noninvasive parameters from pediatric intensive care populations. Design Retrospective observational cohort stud…
View article: Intravenous Bronchodilators in Pediatric Critical Asthma: A Systematic Review and Network Meta‐Analysis
Intravenous Bronchodilators in Pediatric Critical Asthma: A Systematic Review and Network Meta‐Analysis Open
Introduction Pediatric critical asthma is one of the most common pediatric illnesses in children admitted to the pediatric ward and pediatric intensive care unit (PICU). Adjunct intravenous (IV) bronchodilators are often used when initial …
View article: AARC and PALISI Clinical Practice Guideline: Pediatric Critical Asthma
AARC and PALISI Clinical Practice Guideline: Pediatric Critical Asthma Open
To address the lack of guidance for clinicians in their care of children with critical asthma, a multidisciplinary team of medical providers used Grading of Recommendations, Assessment, Development, and Evaluation methodology to make the f…
View article: Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children
Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children Open
NCT03266016; August 23, 2017.
View article: Risk factors for prolonged infection and secondary infection in pediatric severe sepsis
Risk factors for prolonged infection and secondary infection in pediatric severe sepsis Open
View article: Height best predicts the optimal insertion length of orotracheal tubes in children
Height best predicts the optimal insertion length of orotracheal tubes in children Open
Introduction Accurate formulae to predict the optimal insertion length of endotracheal tubes (ETT) are necessary for safe care and have been based on height, weight, age, and ETT size. We believe height best reflects the somatic growth of …
View article: Whole blood transcriptomics identifies subclasses of pediatric septic shock
Whole blood transcriptomics identifies subclasses of pediatric septic shock Open
View article: Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy Open
Background Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal manometry remains the gold standard for monitoring respiratory effort but is invasive and requires expertise …
View article: Determining an Optimal Oxygen Saturation Target Range Based on Neonatal Maturity: Demonstration of a Decision Tree Analytic
Determining an Optimal Oxygen Saturation Target Range Based on Neonatal Maturity: Demonstration of a Decision Tree Analytic Open
The utility of decision tree machine learning in exploring the interactions among the SpO2 target range, neonatal maturity, and oxemic-risk is demonstrated. METHODS: This observational study used 3 years of paired age-SpO2-PaO2 data from a…
View article: Association of Growth Differentiation Factor‐15 With Event Cause and Cardiovascular Failure After Pediatric Cardiac Arrest in a Multi‐Institutional Trial
Association of Growth Differentiation Factor‐15 With Event Cause and Cardiovascular Failure After Pediatric Cardiac Arrest in a Multi‐Institutional Trial Open
View article: Assessment of Brain Magnetic Resonance and Spectroscopy Imaging Findings and Outcomes After Pediatric Cardiac Arrest
Assessment of Brain Magnetic Resonance and Spectroscopy Imaging Findings and Outcomes After Pediatric Cardiac Arrest Open
Importance Morbidity and mortality after pediatric cardiac arrest are chiefly due to hypoxic-ischemic brain injury. Brain features seen on magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) after arrest may identify…
View article: Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study*
Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study* Open
OBJECTIVES: Acute disorders of consciousness (DoC) in pediatric severe sepsis are associated with increased risk of morbidity and mortality. We sought to examine the frequency of and factors associated with DoC in children with sepsis-indu…
View article: Effort and work-of-breathing parameters strongly correlate with increased resistance in an animal model
Effort and work-of-breathing parameters strongly correlate with increased resistance in an animal model Open
View article: The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study
The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study Open
Background The end-tidal alveolar dead space fraction (AVDSf = [PaCO 2 −P ET CO 2 ]/PaCO 2 ) is a metric used to estimate alveolar dead space. Higher AVDSf on the first day of mechanical ventilation is associated with mortality and fewer v…
View article: Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials Open
View article: Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document
Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document Open
Rationale: Pediatric-specific ventilator liberation guidelines are lacking despite the many studies exploring elements of extubation readiness testing. The lack of clinical practice guidelines has led to significant and unnecessary …
View article: Operational Definitions Related to Pediatric Ventilator Liberation
Operational Definitions Related to Pediatric Ventilator Liberation Open
View article: Mortality Risk in Pediatric Sepsis Based on C-reactive Protein and Ferritin Levels
Mortality Risk in Pediatric Sepsis Based on C-reactive Protein and Ferritin Levels Open
OBJECTIVES: Interest in using bedside C-reactive protein (CRP) and ferritin levels to identify patients with hyperinflammatory sepsis who might benefit from anti-inflammatory therapies has piqued with the COVID-19 pandemic experience. Our …
View article: Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy
Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy Open
How to deliver best care in various clinical settings remains a vexing problem. All pertinent healthcare-related questions have not, cannot, and will not be addressable with costly time- and resource-consuming controlled clinical trials. A…
View article: Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest
Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest Open
In this cohort study, blood-based brain injury biomarkers, especially NfL, were associated with an unfavorable outcome at 1 year after pediatric cardiac arrest. Additional evaluation of the accuracy of the association between biomarkers an…
View article: A 30-Minute Spontaneous Breathing Trial Misses Many Children Who Go On to Fail a 120-Minute Spontaneous Breathing Trial
A 30-Minute Spontaneous Breathing Trial Misses Many Children Who Go On to Fail a 120-Minute Spontaneous Breathing Trial Open
View article: Clinical Challenges in Pediatric Ventilation Liberation: A Meta-Narrative Review
Clinical Challenges in Pediatric Ventilation Liberation: A Meta-Narrative Review Open
OBJECTIVES: To map the evidence for ventilation liberation practices in pediatric respiratory failure using the Realist And MEta-narrative Evidence Syntheses: Evolving Standards publication standards. DATA SOURCES: CINAHL, MEDLINE, COCHRAN…
View article: Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices
Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices Open
View article: Continuous noninvasive blood gas estimation in critically ill pediatric patients with respiratory failure
Continuous noninvasive blood gas estimation in critically ill pediatric patients with respiratory failure Open
View article: Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock
Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock Open
OBJECTIVES: To determine the association of pathogen type with mortality, functional status, and health-related quality of life (HRQL) among children at hospital discharge/1 month following hospitalization for septic shock. DESIGN: Seconda…
View article: Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials
Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials Open
View article: Normalization to Predicted Body Weight May Underestimate Mechanical Energy in Pediatric Acute Respiratory Distress Syndrome
Normalization to Predicted Body Weight May Underestimate Mechanical Energy in Pediatric Acute Respiratory Distress Syndrome Open
"Normalization to Predicted Body Weight May Underestimate Mechanical Energy in Pediatric Acute Respiratory Distress Syndrome." American Journal of Respiratory and Critical Care Medicine, 205(11), pp. 1360–1363
View article: High-Flow Nasal Cannula Reduces Effort of Breathing But Not Consistently via Positive End-Expiratory Pressure
High-Flow Nasal Cannula Reduces Effort of Breathing But Not Consistently via Positive End-Expiratory Pressure Open
Increasing HFNC in children with bronchiolitis reduces the effort of breathing, but no consistent increase occurs in end-expiratory lung volume and no significant change occurs in VT or transpulmonary pressure. This suggests tha…
View article: Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury
Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury Open
In this comparative effectiveness research study, bolus HTS was associated with lower ICP and higher CPP, whereas mannitol was associated only with higher CPP. After adjustment for confounders, both therapies showed no association with ICP…
View article: Blood-Based Brain Injury Biomarkers to Prognosticate Outcome after Pediatric Cardiac Arrest
Blood-Based Brain Injury Biomarkers to Prognosticate Outcome after Pediatric Cardiac Arrest Open
Background Prognostication after cardiac arrest in children is challenging due to a lack of validated methods to evaluate direct brain injury. The objective of this multicenter study was to analyze biomarker accuracy to prognosticate outco…