Christopher J. Murphy
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View article: EMERGE patch, a novel electrogenic engineered material to enhance healing of severe corneal wounds
EMERGE patch, a novel electrogenic engineered material to enhance healing of severe corneal wounds Open
Severe corneal wounds with stromal damage, especially those inflicted in battlefield and terrorist attacks, remain a significant clinical challenge. Naturally occurring wound electric fields have been demonstrated to have powerful effects …
View article: Clinical and histopathological features of proliferative corneal lesions in <i>Cyprininae</i> fishes: Implications for treatment and insights into corneal tumors
Clinical and histopathological features of proliferative corneal lesions in <i>Cyprininae</i> fishes: Implications for treatment and insights into corneal tumors Open
Captive fish populations, such as those encompassing aquarium and pet fish, offer significant economic value and are integral to conservation, research, and education. However, these ornamental fish exhibit a reduced ability to protect the…
View article: Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy
Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy Open
There are common phenotypic abnormalities seen between Wwtr1 deficient and FECD-affected patients, suggesting that Wwtr1 deficient mice could function as a murine model of late-onset FECD. Despite the lack of a genetic association between …
View article: Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model.
Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model. Open
We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. Further knowledge of the biophysical cues involved in determining cor…
View article: Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane
Identification of putative orthologs of clinically relevant antimicrobial peptides in the equine ocular surface and amniotic membrane Open
Objectives This study aimed to define the antimicrobial peptide (AMP) expression pattern of the equine ocular surface and amniotic membrane using a targeted qPCR approach and 3'Tag‐sequencing. It will serve as a reference for future studie…
View article: Theory Techniques for Precision Physics -- Snowmass 2021 TF06 Topical Group Report
Theory Techniques for Precision Physics -- Snowmass 2021 TF06 Topical Group Report Open
The wealth of experimental data collected at laboratory experiments suggests that there is some scale separation between the Standard Model (SM) and phenomena beyond the SM (BSM). New phenomena can manifest itself as small corrections to S…
View article: <i>Arap1</i> loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death
<i>Arap1</i> loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death Open
Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-ac…
View article: Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis
Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis Open
Microbial keratitis is a common cause of ocular pain and visual impairment worldwide. The ocular surface has a relatively paucicellular microbial community, mostly found in the conjunctiva, while the cornea would be considered relatively s…
View article: Dysphagia Lusoria Because of Congenital Double Aortic Arch
Dysphagia Lusoria Because of Congenital Double Aortic Arch Open
CASE REPORT A 61-year-old woman presented with a 5-year history of intermittent, nonprogressive solid food dysphagia. She endorsed mild, occasional heartburn and reflux but had no other red flag symptoms. An esophagogastroduodenoscopy was …
View article: Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility
Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility Open
Acute primary angle closure glaucoma (PACG) is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. Canine PACG is epidemiologically similar to humans with ol…
View article: Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
Multimodal ocular imaging of known and novel corneal stromal disorders in dogs Open
Background Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported in dogs. This case report is a compilation of i…
View article: Cost-Benefit Analysis of the Pigmented Lesion Assay When Introduced Into the Visual Assessment / Histopathology Pathway for Lesions Clinically Suspicious for Melanoma
Cost-Benefit Analysis of the Pigmented Lesion Assay When Introduced Into the Visual Assessment / Histopathology Pathway for Lesions Clinically Suspicious for Melanoma Open
Objective: To evaluate the potential savings to health plans when the Pigmented Lesion Assay(PLA) is incorporated into the assessment of pigmented lesions clinically suspicious formelanoma.Methods: A Return on Investment (ROI) model was de…
View article: Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation
Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation Open
These experimental results can apply to human nanomedical research.
View article: Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing
Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing Open
Silver nanoparticles (AgNPs) are a common antimicrobial additive for a variety of applications, including wound care. However, AgNPs often undergo dissolution resulting in release of silver ions, with subsequent toxicity to mammalian cells…
View article: Effect of Withdrawing Chronic Topical Immune Modulating Treatment on Schirmer Tear Test Values in Dogs with Dry Eye Disease: Relevance to Dry Eye Studies
Effect of Withdrawing Chronic Topical Immune Modulating Treatment on Schirmer Tear Test Values in Dogs with Dry Eye Disease: Relevance to Dry Eye Studies Open
Purpose: To determine the effect of discontinuing chronic topical immune modulating (IM) treatment on Schirmer tear test (STT) values in dogs with dry eye disease (DED). Methods: Serial measurements of STTs from 14 dogs (16 eyes) previousl…
View article: Correlations between clinical signs and corneal cytology in feline eosinophilic keratoconjunctivitis
Correlations between clinical signs and corneal cytology in feline eosinophilic keratoconjunctivitis Open
Objective To assess correlations between clinical and cytological features of feline eosinophilic keratoconjunctivitis at the time of cytological diagnosis. Animals Studied Fifteen client‐owned, domestic breed cats (18 eyes) examined betwe…
View article: Animal models of corneal endothelial dysfunction to facilitate development of novel therapies
Animal models of corneal endothelial dysfunction to facilitate development of novel therapies Open
Progressive corneal endothelial disease eventually leads to corneal edema and vision loss due to the limited regenerative capacity of the corneal endothelium in vivo and is a major indication for corneal transplantation. Despite the relati…
View article: Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8
Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8 Open
This study provides detailed clinical characterization of retinopathy in adult Cln8-/- mice. Findings suggest that Cln8-/- mice may provide a useful murine model for development of novel therapeutics needed for treating ocular disease in p…
View article: Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor
Changing the Wound: Covalent Immobilization of the Epidermal Growth Factor Open
Re-epithelialization of wounds is a critical element of wound closure. Growth factors have been used in combination with conventional wound management to promote closure, but the method of delivery has been limited to the topical applicati…
View article: Differential effects of Hsp90 inhibition on corneal cells in vitro and in vivo
Differential effects of Hsp90 inhibition on corneal cells in vitro and in vivo Open
The transformation of quiescent keratocytes to activated fibroblasts and myofibroblasts (KFM transformation) largely depends on transforming growth factor beta (TGFβ) signaling. Initiation of the TGFβ signaling cascade results from binding…
View article: Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma
Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma Open
Intrastromal HAse injection appears relatively safe in the normal cornea, but its impact on corneal biomechanics and structure under pathologic conditions requires further study.