Christopher J.D. Wallis
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View article: Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer
Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer Open
There is an unmet need for a tool that could predict early favorable prostate-specific antigen (PSA) response in metastatic hormone sensitive prostate cancer (mHSPC) patients receiving androgen receptor pathway inhibitor (ARPI). Here, we t…
View article: Efficacy and safety of treatments for metastatic castration-sensitive prostate cancer: A comprehensive network meta-analysis including final ARANOTE data
Efficacy and safety of treatments for metastatic castration-sensitive prostate cancer: A comprehensive network meta-analysis including final ARANOTE data Open
This NMA supports the superior efficacy of ARPI combinations against ADT monotherapy, for both OS and PFS. While DAR + ADT demonstrated comparable efficacy to other doublet combinations, it offered a superior safety profile, making it an e…
View article: Complications of Robotic Pelvic Lymph Node Dissection for Prostate Cancer: An Analysis of the National Surgical Quality Improvement Program Targeted Prostatectomy Database
Complications of Robotic Pelvic Lymph Node Dissection for Prostate Cancer: An Analysis of the National Surgical Quality Improvement Program Targeted Prostatectomy Database Open
Introduction/Background: Treatment of localized prostate cancer includes radical prostatectomy (RP) with or without pelvic lymph node dissection (PLND). While multiple guidelines recommend PLND for staging purposes, recent data has shown q…
View article: Association of patient and physician characteristics with androgen‐deprivation‐therapy intensification in patients with de novo hormone‐sensitive metastatic prostate cancer: A population‐based study
Association of patient and physician characteristics with androgen‐deprivation‐therapy intensification in patients with de novo hormone‐sensitive metastatic prostate cancer: A population‐based study Open
Introduction Treatment intensification with androgen receptor signaling inhibitors and/or chemotherapy is guideline recommended for patients with de novo metastatic hormone‐sensitive prostate cancer (mHSPC). However, most patients only rec…
View article: The Association Between Online Surgeon Ratings and Patients’ Postoperative Outcomes in the United States
The Association Between Online Surgeon Ratings and Patients’ Postoperative Outcomes in the United States Open
Objective: To determine whether ratings are associated with postoperative outcomes. Background: Online ratings by patients or inclusion on lists of exceptional physicians are publicly available. Methods: In this retrospective study, Medica…
View article: A population-based analysis of patterns of care in patients with de novo muscle-invasive bladder cancer from Alberta, Canada
A population-based analysis of patterns of care in patients with de novo muscle-invasive bladder cancer from Alberta, Canada Open
Introduction: Approximately 25% of patients diagnosed with bladder cancer have muscle-invasive disease (MIBC). While real-world data have highlighted opportunities to improve curative-intent treatment rates, comprehensive population-level …
View article: Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials
Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials Open
Importance The impact of statins on overall survival (OS) in patients with prostate cancer treated using intensified therapy with apalutamide is not fully understood. Objective To determine whether statin exposure was associated with OS an…
View article: A population-based analysis of patterns of care in patients with high-risk non-muscle-invasive bladder cancer from Alberta, Canada
A population-based analysis of patterns of care in patients with high-risk non-muscle-invasive bladder cancer from Alberta, Canada Open
Introduction: Approximately three-quarters of patients newly diagnosed with bladder cancer have non-muscle-invasive disease (NMIBC). Among these patients, those with high-risk (HR) features should be managed more aggressively in an attempt…
View article: Association of race and 30-day postoperative complications after urologic oncology surgery
Association of race and 30-day postoperative complications after urologic oncology surgery Open
Introduction: We aimed to evaluate the association between race and postoperative complications in patients undergoing urologic cancer surgeries, comparing 30-day outcomes between black and white-identifying patients using propensity-score…
View article: Comparison of Mortality and Morbidity of Robotic Versus Laparoscopic Radical Nephrectomy for the Treatment of Renal Cell Carcinoma—An Analysis of the National Surgery Quality Improvement Program (NSQIP) Targeted Nephrectomy Database
Comparison of Mortality and Morbidity of Robotic Versus Laparoscopic Radical Nephrectomy for the Treatment of Renal Cell Carcinoma—An Analysis of the National Surgery Quality Improvement Program (NSQIP) Targeted Nephrectomy Database Open
Objectives: To compare the perioperative complications between robot-assisted (RARN) and laparoscopic (LRN) radical nephrectomy for the treatment of renal cell carcinoma (RCC). Methods: We conducted a retrospective study using the National…
View article: Surgeon Sex and Postoperative Resource Utilization: A Population-Based Cohort Study
Surgeon Sex and Postoperative Resource Utilization: A Population-Based Cohort Study Open
Objectives: To determine associations between physician sex and use of postoperative healthcare resources among patients undergoing common surgeries in Ontario, Canada. Background: Prior studies have shown that patients of female physician…
View article: Association of Deep and Durable Prostate-specific Antigen Responses with Outcomes in Metastatic Hormone-sensitive Prostate Cancer: Insights from ARASENS and ARANOTE Trials
Association of Deep and Durable Prostate-specific Antigen Responses with Outcomes in Metastatic Hormone-sensitive Prostate Cancer: Insights from ARASENS and ARANOTE Trials Open
Joint modeling demonstrates a strong association between PSA dynamics and OS, underscoring darolutamide's potential to positively influence PSA trajectories and improve survival in mHSPC.
View article: Postoperative Outcomes Following Preweekend Surgery
Postoperative Outcomes Following Preweekend Surgery Open
Importance The phenomenon of a weekend effect refers to a higher potential for adverse outcomes in patients receiving care over the weekend. Few prior studies have comprehensively investigated the effects of postoperative weekend care on s…
View article: The association between physician sex and patient outcomes: a systematic review and meta-analysis
The association between physician sex and patient outcomes: a systematic review and meta-analysis Open
Background Some prior studies have found that patients treated by female physicians may experience better outcomes, as well as lower healthcare costs than those treated by male physicians. Physician–patient sex concordance may also contrib…
View article: Patient-reported functional outcomes and treatment-related regret in Hispanic and Spanish-speaking men following prostate cancer treatment
Patient-reported functional outcomes and treatment-related regret in Hispanic and Spanish-speaking men following prostate cancer treatment Open
These findings underscore the importance of considering language and ethnicity when providing counseling and support for prostate cancer survivors, emphasizing the need for personalized patient-centered care.
View article: Proportion of Gleason Score ≥8 Prostate Cancer on Biopsy and Tumor Aggressiveness in Matched Cohorts of East Asian and Non-East Asian Men
Proportion of Gleason Score ≥8 Prostate Cancer on Biopsy and Tumor Aggressiveness in Matched Cohorts of East Asian and Non-East Asian Men Open
Background: Historically, Asia had a lower prostate cancer (PCa) incidence and mortality compared with Western countries, but the gap is narrowing. Paradoxically, Asians have been reported to present with more advanced disease though more …
View article: Prior Local Therapy and First-Line Apalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer
Prior Local Therapy and First-Line Apalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Open
Importance Preclinical studies suggest that exposure to prostate-directed local therapy (LT) may influence the efficacy of subsequent systemic therapy including androgen receptor pathway inhibitors. However, there is insufficient clinical …
View article: Metabolic, cardiac, and bone health testing in patients with prostate cancer on androgen‐deprivation therapy: A population‐based assessment of adherence to therapeutic monitoring guidelines
Metabolic, cardiac, and bone health testing in patients with prostate cancer on androgen‐deprivation therapy: A population‐based assessment of adherence to therapeutic monitoring guidelines Open
Background Androgen‐deprivation therapy (ADT) remains a cornerstone in treatment for patients with advanced prostate cancer. ADT is associated with several adverse effects, including osteoporosis, metabolic syndrome, and cardiovascular eve…
View article: Absence of Race/Ethnicity Reporting in Clinical Trials of True Minimally Invasive Surgical Therapies for the Treatment of Benign Prostatic Hyperplasia
Absence of Race/Ethnicity Reporting in Clinical Trials of True Minimally Invasive Surgical Therapies for the Treatment of Benign Prostatic Hyperplasia Open
None of the 61 included publications of RCTs of office-based MISTs provided information on racial/ethnic composition of study participants. There is a staggering gap in the standardization of race/ethnicity reporting and enrollment within …
View article: Association of chronic kidney disease with postoperative outcomes: a national surgical quality improvement program (NSQIP) multi-specialty surgical cohort analysis
Association of chronic kidney disease with postoperative outcomes: a national surgical quality improvement program (NSQIP) multi-specialty surgical cohort analysis Open
This population-based study demonstrates the negative impact of CKD on operative outcomes across a diverse range of procedures and patients.
View article: Practice patterns and predictors of treatment intensification in patients with metastatic castration-sensitive prostate cancer
Practice patterns and predictors of treatment intensification in patients with metastatic castration-sensitive prostate cancer Open
Introduction: Treatment intensification beyond androgen deprivation therapy (ADT) has shown survival benefit in patients with metastatic castration-sensitive prostate cancer (mCSPC). There is a need to better understand how these novel tre…
View article: 5-α Reductase Inhibitors and Prostate Cancer Mortality
5-α Reductase Inhibitors and Prostate Cancer Mortality Open
Importance 5-alpha-reductase-inhibitors (5-ARIs) are approved for treating benign prostatic hyperplasia (BPH) and have been found to reduce prostate cancer (PCa) risk by 25%. However, trials also have shown 5-ARIs to be associated with hig…
View article: Canadian Association of Radiologists Genitourinary Imaging Referral Guideline
Canadian Association of Radiologists Genitourinary Imaging Referral Guideline Open
The Canadian Association of Radiologists (CAR) Genitourinary Expert Panel is made up of physicians from the disciplines of radiology, emergency medicine, family medicine, nephrology, and urology, a patient advisor, and an epidemiologist/gu…
View article: Association Between Surgeon Sex and Days Alive at Home Following Surgery: A Population-Based Cohort Study
Association Between Surgeon Sex and Days Alive at Home Following Surgery: A Population-Based Cohort Study Open
Objective: The objective of this study was to measure potential associations between surgeon sex and number of days alive and at home (DAH). Background: Patients treated by female surgeons appear to have lower rates of mortality, complicat…