Explanipedia

Lung basement membranes are compositionally and structurally altered following resolution of acute inflammation Open

Stephan Brand, Sara Kirkham, Christopher Jagger, Matiss Ozols, Rachel Lennon , et al. · 2024

Identification of pathways preventing recovery from acute respiratory viral infection is under-studied but essential for long-term health. Using unbiased proteomics, we reveal an unexpected persistent reduction in lung basement membrane pr…

Kidney resident macrophages have distinct subsets and multifunctional roles Open

Christine Chew, Stephan Brand, Tomohiko Yamamura, Craig Lawless, Mychel Morais , et al. · 2024

We identified CD81 and CX₃CR1 positive kidney macrophage subsets with distinct dependence for monocyte replenishment. Multiomic analysis demonstrated that these cells have diverse functions that underscore the importance of macr…

Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID Open

Nicholas A. Scott, Laurence Pearmain, Sean Knight, Stephan Brand, David J. Morgan , et al. · 2023

Background COVID-19 is associated with a dysregulated immune response but it is unclear how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 patients during convalescence (long COVID). Methods We assessed…

Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19 Open

Julie Wilson, David Kealy, Sally James, Tobias Plowman, Katherine Newling , et al. · 2021

Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with similar circulating CC levels present with different disease severity. Here, we determined 171 microRNAomes from 58 hospitalized COVID-19 patients (Coh…

P058 Persistence of neutrophil abnormalities in COVID-19 convalescence Open

Thomas O. Williams, Verena Kästele, Elizabeth R. Mann, Sean Knight, Madhvi Menon , et al. · 2021

Background/Aims Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may develop acute respiratory inflammation, due to an exaggerated immune response and some develop chronic complications. Neutrophils play …

Alterations in T and B cell function persist in convalescent COVID-19 patients Open

Halima Ali Shuwa, Tovah N. Shaw, Sean Knight, Kelly Wemyss, Flora A. McClure , et al. · 2021

Provided by UKRI, Lister Institute of Preventative Medicine, the Wellcome Trust, The Kennedy Trust for Rheumatology Research, and 3M Global Giving.

Integrated miRNA/Cytokine/Chemokine Profiling Reveals Severity-Associated Step Changes and Principal Correlates of Fatality in COVID-19 Open

Julie Wilson, David Kealy, Sally James, Tobias Plowman, Katherine Newling , et al. · 2021

Recovery of monocyte exhaustion is associated with resolution of lung injury in COVID-19 convalescence Open

Nicholas A. Scott, Sean Knight, Laurence Pearmain, Stephan Brand, David J. Morgan , et al. · 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the clinical syndrome COVID-19 is associated with an exaggerated immune response and monocyte infiltrates in the lungs and other peripheral tissues. It is …

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 Open

Elizabeth R. Mann, Madhvi Menon, Sean Knight, Joanne E. Konkel, Christopher Jagger , et al. · 2020

Longitudinal analysis of the immune response in patients with COVID-19 identifies a myeloid signature associated with severe disease.

Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency Open

Anu Goenka, John A. Doherty, Tariq Al-Farsi, Christopher Jagger, Siddharth Banka , et al. · 2020

The glucose-6-phosphatase catalytic subunit 3 (G6PC3) encodes a ubiquitously expressed enzyme that regulates cytoplasmic glucose availability. Loss-of-function biallelic G6PC3 mutations cause severe congenital neutropenia and a diverse spe…

Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis Open

Elizabeth R. Mann, Madhvi Menon, Sean Knight, Joanne E. Konkel, Christopher Jagger , et al. · 2020

Background The pathogenesis of COVID-19, caused by a novel strain of coronavirus (SARS-CoV-2), involves a complex host-virus interaction and is characterised by an exaggerated immune response, the specific components of which are poorly un…

Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients Open

Halima Ali Shuwa, Tovah N. Shaw, Sean Knight, Flora A. McClure, Kelly Wemyss , et al. · 2020

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases Open

Naoya Fujino, Stephan Brand, David J. Morgan, Toshifumi Fujimori, Aleksander M. Grabiec , et al. · 2019

Epithelial cell proliferation, division, and differentiation are critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Here we define that sensing of apoptotic cells by the TAM receptor ty…

Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia Open

David J. Morgan, Joshua Casulli, Christine Chew, Emma Connolly, Sylvia Lui , et al. · 2018

Secondary infections arise as a consequence of previous or concurrent conditions and occur in the community or in the hospital setting. The events allowing secondary infections to gain a foothold have been studied for many years and includ…

The consequence of matrix dysfunction on lung immunity and the microbiome in COPD Open

Tracy Hussell, Sylvia Lui, Christopher Jagger, David J. Morgan, Stephan Brand · 2018

The pulmonary extracellular matrix (ECM) is a complex network of proteins which primarily defines tissue architecture and regulates various biochemical and biophysical processes. It is a dynamic system comprising two main structures (the i…

Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis Open

Thomas J. Bell, Stephan Brand, David J. Morgan, Samira Salek‐Ardakani, Christopher Jagger , et al. · 2018

Little is known about the impact of viral infections on lung matrix despite its important contribution to mechanical stability and structural support. The composition of matrix also indirectly controls inflammation by influencing cell adhe…

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