Christopher K. McLaughlin
YOU?
Author Swipe
View article: Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations Open
While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. …
View article: A New Spin on Antibody–Drug Conjugates: Trastuzumab-Fulvestrant Colloidal Drug Aggregates Target HER2-Positive Cells
A New Spin on Antibody–Drug Conjugates: Trastuzumab-Fulvestrant Colloidal Drug Aggregates Target HER2-Positive Cells Open
While the formation of colloidal aggregates leads to artifacts in early drug discovery, their composition makes them attractive as nanoparticle formulations for targeted drug delivery as the entire nanoparticle is composed of drug. The typ…
View article: Internal Structure and Preferential Protein Binding of Colloidal Aggregates
Internal Structure and Preferential Protein Binding of Colloidal Aggregates Open
Colloidal aggregates of small molecules are the most common artifact in early drug discovery, sequestering and inhibiting target proteins without specificity. Understanding their structure and mechanism has been crucial to developing tools…
View article: Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles
Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles Open
Researchers demonstrate that encapsulation is not necessary to achieve controlled, long-term protein release.
View article: Stable Colloidal Drug Aggregates Catch and Release Active Enzymes
Stable Colloidal Drug Aggregates Catch and Release Active Enzymes Open
Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the coaggregation of seven mol…
View article: Innovative use of the taxol binding peptide overcomes key challenges of stable and high drug loading in polymeric nanomicelles
Innovative use of the taxol binding peptide overcomes key challenges of stable and high drug loading in polymeric nanomicelles Open
Incorporating a taxol binding peptide into the hydrophobic backbone of polymeric nanomicelles enhances docetaxel loading while maintaining serum stability.