Christopher L. Karp
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View article: A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
A BAFF/APRIL axis regulates obesogenic diet-driven weight gain Open
View article: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis Open
The Editors recently posted an Expression of Concern for this article due to duplication of some of the flow cytometry plots in Figures 5C and7A (1).The authors have completed three replicate experiments for the panels in question, and the…
View article: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis Open
The Editors recently became aware that some of the flow cytometry plots in this article were duplicated and used to represent different samples.Specifically, in Figure 5C, the flow cytometry plots of IFN-γ-and IL-17-stained cells from IgG1…
View article: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling Open
View article: Type I interferons regulate susceptibility to inflammation-induced preterm birth
Type I interferons regulate susceptibility to inflammation-induced preterm birth Open
Preterm birth (PTB) is a leading worldwide cause of morbidity and mortality in infants. Maternal inflammation induced by microbial infection is a critical predisposing factor for PTB. However, biological processes associated with competenc…
View article: A reply to DeVico, Lewis & Gallo (2015)
A reply to DeVico, Lewis & Gallo (2015) Open
We appreciate the thoughtful comments provided by DeVico et al. [1] regarding the section of our opinion piece (Wilson & Karp [2]) that discussed the problem of limited durability of HIV-vaccine-induced antibody responses in humans. They h…
View article: Transformative tools for tackling tuberculosis
Transformative tools for tackling tuberculosis Open
The world is in need of more effective approaches to controlling tuberculosis. The development of improved control strategies has been hampered by deficiencies in the tools available for detecting Mycobacterium tuberculosis and defining th…
View article: Evaluating the value proposition for improving vaccine thermostability to increase vaccine impact in low and middle-income countries
Evaluating the value proposition for improving vaccine thermostability to increase vaccine impact in low and middle-income countries Open
The need to keep vaccines cold in the face of high ambient temperatures and unreliable access to electricity is a challenge that limits vaccine coverage in low and middle-income countries (LMICs). Greater vaccine thermostability is general…
View article: Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?
Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges? Open
Vaccines are one of the most impactful and cost-effective public health measures of the twentieth century. However, there remain great unmet needs to develop vaccines for globally burdensome infectious diseases and to allow more timely res…
View article: Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool
Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool Open
Summary The road to a more efficacious vaccine that could be a truly transformative tool for decreasing tuberculosis morbidity and mortality, along with M ycobacterium tuberculosis transmission, is quite daunting. Despite this, there are r…