Christopher L. Murphy
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View article: The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins
The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins Open
Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG…
View article: High-Throughput Identification of MiR-145 Targets in Human Articular Chondrocytes
High-Throughput Identification of MiR-145 Targets in Human Articular Chondrocytes Open
MicroRNAs (miRNAs) play key roles in cartilage development and homeostasis and are dysregulated in osteoarthritis. MiR-145 modulation induces profound changes in the human articular chondrocyte (HAC) phenotype, partially through direct rep…
MEF2C is a new regulator of the human articular chondrocyte phenotype Open
MEF2C plays a role in diverse tissues, most notably heart, brain, eyes and developing bones. Here we report for the first time that MEF2C is present and active in the permanent articular cartilage in humans which lines and protects our joi…