Christopher Lin
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View article: Target Engagement in a Head-to-head Clinical Trial of Dysphoric versus Anxiosomatic TMS Targets
Target Engagement in a Head-to-head Clinical Trial of Dysphoric versus Anxiosomatic TMS Targets Open
Functional connectivity (FC) is increasingly used to measure target engagement following transcranial magnetic stimulation (TMS), but whether FC changes are specific to the TMS target remains unclear. We examined FC before and after TMS in…
View article: A Human Gait Circuit Derived from Brain Lesions and Deep Brain Stimulation
A Human Gait Circuit Derived from Brain Lesions and Deep Brain Stimulation Open
Objectives: The relevant neuroanatomy for gait dysfunction remains unclear. We sought 1) to identify a brain circuit for gait impairment post stroke, 2) to identify a brain circuit for gait changes after subthalamic DBS for Parkinson′s dis…
View article: Prediction of stroke severity: systematic evaluation of lesion representations
Prediction of stroke severity: systematic evaluation of lesion representations Open
Objective To systematically evaluate which lesion‐based imaging features and methods allow for the best statistical prediction of poststroke deficits across independent datasets. Methods We utilized imaging and clinical data from three ind…
View article: Symptom-specific brain circuit stimulation: A head-to-head randomized trial
Symptom-specific brain circuit stimulation: A head-to-head randomized trial Open
Transcranial magnetic stimulation (TMS) is effective for major depressive disorder (MDD) despite imprecise scalp-based targeting. Retrospective analyses suggest that targeting one brain circuit improves “dysphoric” symptoms, while targetin…
View article: Mapping Lesions that Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target
Mapping Lesions that Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target Open
Importance Identifying anatomy causally involved in psychosis could inform therapeutic neuromodulation targets for schizophrenia. Objective To assess whether lesions that cause secondary psychosis have functional connections to a common br…
View article: Abstract 1276 Development of Methods to Test and Characterize Proteases in Human Saliva
Abstract 1276 Development of Methods to Test and Characterize Proteases in Human Saliva Open
Proteases play critically important roles in humans and abnormal activity is linked to a number of diseases. The proteases in saliva play a role in digestion of food and protection; abnormal activity can lead to periodontal disease among o…
View article: Mapping Lesion-Related Epilepsy to a Human Brain Network
Mapping Lesion-Related Epilepsy to a Human Brain Network Open
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with epilepsy by mapping these lesions could inform prognosis and guide interventions. Obj…
View article: Know Thy Strengths: Comprehensive Dialogue State Tracking Diagnostics
Know Thy Strengths: Comprehensive Dialogue State Tracking Diagnostics Open
Hyundong Cho, Chinnadhurai Sankar, Christopher Lin, Kaushik Sadagopan, Shahin Shayandeh, Asli Celikyilmaz, Jonathan May, Ahmad Beirami. Findings of the Association for Computational Linguistics: EMNLP 2022. 2022.
View article: Network Localization of Unconscious Visual Perception in Blindsight
Network Localization of Unconscious Visual Perception in Blindsight Open
Objective Blindsight is a disorder where brain injury causes loss of conscious but not unconscious visual perception. Prior studies have produced conflicting results regarding the neuroanatomical pathways involved in this unconscious perce…
View article: Know Thy Strengths: Comprehensive Dialogue State Tracking Diagnostics
Know Thy Strengths: Comprehensive Dialogue State Tracking Diagnostics Open
Recent works that revealed the vulnerability of dialogue state tracking (DST) models to distributional shifts have made holistic comparisons on robustness and qualitative analyses increasingly important for understanding their relative per…
View article: An epilepsy network derived from human brain lesions and deep brain stimulation
An epilepsy network derived from human brain lesions and deep brain stimulation Open
Background: Focal epilepsy is increasingly conceptualized as a disease of brain networks, but the network localization remains poorly understood. Lesion locations associated with epilepsy may help identify epilepsy networks and lead to new…
View article: rTMS to the contralesional M1 modulates the trajectory of post-stroke motor recovery
rTMS to the contralesional M1 modulates the trajectory of post-stroke motor recovery Open
Background: Randomized rTMS trials targeting the contralesional M1 have failed to augment behavioral motor recovery interventions post stroke. One possibility is that patients with lesions to different brain networks show different respons…
View article: Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids
Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids Open
Organoids are three-dimensional cell cultures that mimic organ functions and structures. The organoid model has been developed as a versatile in vitro platform for stem cell biology and diseases modeling. Tumor organoids are shown to share…
View article: Active Learning with Unbalanced Classes and Example-Generation Queries
Active Learning with Unbalanced Classes and Example-Generation Queries Open
Machine learning in real-world high-skew domains is difficult, because traditional strategies for crowdsourcing labeled training examples are ineffective at locating the scarce minority-class examples. For example, both random sampling and…
View article: Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy
Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy Open
Chemotherapy has been shown to enrich cancer stem cells in tumors. Recently, we demonstrated that administration of chemotherapy to human bladder cancer xenografts could trigger a wound-healing response that mobilizes quiescent tumor stem …