Christopher Lowden
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View article: Aneuploidy drives the acquisition of cancer-specific driver genes
Aneuploidy drives the acquisition of cancer-specific driver genes Open
Chromosome instability is highly prevalent in cancer and drives large scale chromosomal imbalances, known as aneuploidies. However, how aneuploidy contributes to tumorigenesis remains difficult to study due to the vast numbers of genes aff…
View article: Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models
Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models Open
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circu…
View article: Protracted neuronal maturation in a long-lived, highly social rodent
Protracted neuronal maturation in a long-lived, highly social rodent Open
Naked mole-rats are a long-lived rodent species (current lifespan >37 years) and an increasingly popular biomedical model. Naked mole-rats exhibit neuroplasticity across their long lifespan. Previous studies have begun to investigate their…
View article: MegaSyn: Integrating Generative Molecule Design, Automated Analog Designer and Synthetic Viability Prediction
MegaSyn: Integrating Generative Molecule Design, Automated Analog Designer and Synthetic Viability Prediction Open
Drug discovery is a multi-stage process, often beginning with the identification of active molecules from a high-throughput screen or machine learning model. Once structure activity relationship trends become well established, identifying …
View article: MegaSyn: Integrating Generative Molecule Design, Automated Analog Designer and Synthetic Viability Prediction
MegaSyn: Integrating Generative Molecule Design, Automated Analog Designer and Synthetic Viability Prediction Open
Drug discovery is a multi-stage process, often beginning with the identification of active molecules from a high-throughput screen or machine learning model. Once structure activity relationship trends become well established, identifying …
View article: Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival
Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival Open
Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mic…
View article: Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein
Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein Open
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identify a copper-linked signaling circuit…
View article: Early Metazoan Origin and Multiple Losses of a Novel Clade of RIM Presynaptic Calcium Channel Scaffolding Protein Homologs
Early Metazoan Origin and Multiple Losses of a Novel Clade of RIM Presynaptic Calcium Channel Scaffolding Protein Homologs Open
The precise localization of CaV2 voltage-gated calcium channels at the synapse active zone requires various interacting proteins, of which, Rab3-interacting molecule or RIM is considered particularly important. In vertebrates, RIM interact…
View article: Early metazoan origin and multiple losses of a novel clade of RIM pre-synaptic calcium channel scaffolding protein homologues
Early metazoan origin and multiple losses of a novel clade of RIM pre-synaptic calcium channel scaffolding protein homologues Open
The precise localization of Ca V 2 voltage-gated calcium channels at the synapse active zone requires various interacting proteins, of which, R ab3 interacting m olecule or RIM is considered particularly important. In vertebrates, RIM inte…
View article: A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies
A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies Open
The central pacemakers of circadian timekeeping systems are highly robust yet adaptable, providing the temporal coordination of rhythms in behavior and physiological processes in accordance with the demands imposed by environmental cycles.…
View article: SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker
SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker Open
Summary: Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other tran…
View article: miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock
miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock Open
The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths…