Christopher M. Bositis
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View article: Experiences of the National Post-Exposure Prophylaxis Hotline (PEPline): Occupational PEP consultation needs and trends, 2014 to 2022
Experiences of the National Post-Exposure Prophylaxis Hotline (PEPline): Occupational PEP consultation needs and trends, 2014 to 2022 Open
PEPline consultations can help raise awareness about PEP availability and timely initiation, and reduce stigma by addressing common misperceptions about bloodborne pathogen transmission mechanisms and likelihood, particularly regarding HIV.
View article: Long‐term outcomes after new onset seizure in children living with <scp>HIV</scp>: A cohort study
Long‐term outcomes after new onset seizure in children living with <span>HIV</span>: A cohort study Open
Objective To determine the long‐term outcomes, including mortality and recurrent seizures, among children living with HIV (CLWH) who present with new onset seizure. Methods Zambian CLWH and new onset seizure were enrolled prospectively to …
View article: Early Initiation of Antiretroviral Therapy is Protective Against Seizures in Children With HIV in Zambia: A Prospective Case–Control Study
Early Initiation of Antiretroviral Therapy is Protective Against Seizures in Children With HIV in Zambia: A Prospective Case–Control Study Open
Background: Seizures are relatively common among children with HIV in low- and middle-income countries and are associated with significant morbidity and mortality. Early treatment with antiretroviral therapy (ART) may reduce this risk by d…
View article: Timely Treatment Translates: A Vision for Eradicating HCV
Timely Treatment Translates: A Vision for Eradicating HCV Open
View article: Study protocol for an efficacy trial of the “PrEP for Health” intervention to increase HIV PrEP use among people who inject drugs
Study protocol for an efficacy trial of the “PrEP for Health” intervention to increase HIV PrEP use among people who inject drugs Open
Background HIV incidence has recently increased among people who inject drugs (PWID) across the United States, with outbreaks occurring in states with long-standing syringe service programs (SSPs) including Massachusetts (MA). Antiretrovir…
View article: Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era
Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era Open
Objective This study describes clinical profiles including human immunodeficiency virus (HIV) disease history and seizure etiology among children living with HIV presenting with new‐onset seizure during the era of antiretroviral therapy (A…
View article: Cohort Study of New Onset Seizure Among Adults With HIV in Zambia: Guidance for Clinical Care and the Need for Expanded Treatment Options
Cohort Study of New Onset Seizure Among Adults With HIV in Zambia: Guidance for Clinical Care and the Need for Expanded Treatment Options Open
View article: Evaluating the impact of antiretroviral and antiseizure medication interactions on treatment effectiveness among outpatient clinic attendees with HIV in Zambia
Evaluating the impact of antiretroviral and antiseizure medication interactions on treatment effectiveness among outpatient clinic attendees with HIV in Zambia Open
Objective Interactions between enzyme‐inducing anti‐seizure medications (EI‐ASMs) and antiretroviral drugs (ARVs) can lead to decreased ARV levels and may increase the likelihood of viral resistance. We conducted a study to determine if co…
View article: Mortality & recurrent seizure risk after new-onset seizure in HIV-positive Zambian adults
Mortality & recurrent seizure risk after new-onset seizure in HIV-positive Zambian adults Open
View article: 1321. The UNZA/UMB MMed ID Collaboration: Training and Retaining HIV Specialist Physicians in Zambia
1321. The UNZA/UMB MMed ID Collaboration: Training and Retaining HIV Specialist Physicians in Zambia Open
Background To mitigate the HIV pandemic and increasing outbreaks of infectious diseases, sub-Saharan African countries need increased healthcare worker capacity at all levels. We describe a successful collaboration between the Ministry of …
View article: Patient-Reported Adverse Effects Associated with Combination Antiretroviral Therapy and Coadministered Enzyme-Inducing Antiepileptic Drugs
Patient-Reported Adverse Effects Associated with Combination Antiretroviral Therapy and Coadministered Enzyme-Inducing Antiepileptic Drugs Open
Concurrent treatment with combination antiretroviral therapy (cART) and an enzyme-inducing antiepileptic drug (EI-AED) is common in resource-limited settings; however, the incidence and impact of adverse effects in cotreated patients is la…
View article: The Arc of Human Immunodeficiency Virus Capacity Development: Insights from a Decade of Partnership for Medical Education in Zambia
The Arc of Human Immunodeficiency Virus Capacity Development: Insights from a Decade of Partnership for Medical Education in Zambia Open
Zambia and other sub-Saharan nations suffer from a critical shortage of trained health-care professionals to combat the human immunodeficiency virus/acquired immunodeficiency syndrome crisis. The University of Maryland and the Zambian Mini…
View article: New-onset seizure in HIV-infected adult Zambians
New-onset seizure in HIV-infected adult Zambians Open
HIV-infected adults with new-onset seizure in Zambia often have advanced HIV disease with OI being the most frequent seizure etiology. Seizure recurrence is common but no risk factors for recurrence other than survival were identified. The…
View article: Acute EEG findings in HIV-infected Zambian adults with new-onset seizure
Acute EEG findings in HIV-infected Zambian adults with new-onset seizure Open
EEG abnormalities are common in this population, particularly in patients with imaging abnormalities and advanced HIV. Acute EEG abnormalities were not associated with recurrent seizure, but high mortality rates during follow-up limited th…