Christopher M Florkowski

Emergency department use of a high-sensitivity point-of-care troponin assay reduces length of stay: an implementation study preliminary report Open

John W. Pickering, Laura R Joyce, Christopher M Florkowski, Vanessa Buchan, Laura Hamill , et al. · 2024

Aims Point-of-care (POC) high-sensitivity troponin (hs-cTn) assays within a clinical pathway may safely reduce length of stay (LoS) for patients presenting to the emergency department (ED) with possible acute myocardial infarction (AMI). I…

Analytical verification of the Atellica VTLi point of care high sensitivity troponin I assay Open

Christopher M Florkowski, Vanessa Buchan, Bobby Li, Felicity Taylor, Minh Phan , et al. · 2024

Objectives The Siemens Point-of-Care Testing (POC) Atellica ® VTLi high-sensitivity troponin I (hsTnI) device has been previously validated. Verification independently provides evidence that an analytical procedure fulfils concordance with…

Commentary on Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Open

Christopher M Florkowski · 2024

evidence that glycerol did not account for all of the TG observed in this patient is found in the lipoprotein metabolism profile and gel electrophoresis results (Fig. 1).In lane 3, clear bands were visible for chylomicrons and VLDL, which …

Reducing Patient Risk and Enhancing Care Through the Development and Implementation of a New Chest Pain Pathway, Expedited by and for the COVID-19 Era Open

Martin Than, John W. Pickering, Philip D Adamson, Thomas Clendon, Christopher M Florkowski , et al. · 2022

The COVID-19 pandemic raised major concerns relating to hospital capacity and cross-infection patients and staff in the Emergency Department (ED) of a metropolitan hospital servicing a population of ~500,000. We determined to reduce length…

Grossly Elevated False-Positive High-Sensitivity Troponin I Due to Heterophilic Antimouse IgG1 Antibodies Open

John G. Lewis, Alison J L Connolly, Hank Ploeg, Ian Phillips, Richard King , et al. · 2020

Although highly sensitive assays for the cardiac troponins are now considered the optimal biomarkers for the diagnosis of acute myocardial infarction, it is becoming increasingly apparent that there may be discordance between the 2 most co…

Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study” Open

Jing Pang, Dick C. Chan, Miao Hu, Lauretta Muir, See Kwok , et al. · 2019

Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study Open

Martin Than, Sally Aldous, Richard W. Troughton, Chris Frampton, Mark Richards , et al. · 2018

BACKGROUND Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentr…

ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome) Open

Martin Than, John W. Pickering, Jeremy M. Dryden, Sarah J. Lord, Stuart A. Aitken , et al. · 2017

Background: Efforts to safely reduce length of stay for emergency department patients with symptoms suggestive of acute coronary syndrome (ACS) have had mixed success. Few system-wide efforts affecting multiple hospital emergency departmen…

Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection Open

John W. Pickering, Martin Than, Louise Cullen, Sally Aldous, Ewoud ter Avest , et al. · 2017

Emergency Care Foundation.

Will the Use of Lyophilized Citrate Tubes Lead to the Over-Diagnosis of Diabetes in Pregnancy? Open

Rebekah Carey, Martin J. Churcher, Ruth Hughes, Christopher M Florkowski, Chris Frampton , et al. · 2017

The International Association of Diabetes and Pregnancy Study Group (IADSPG)1 plasma glucose concentration thresholds used for diagnosing gestational diabetes mellitus (GDM) (1) are based on the risk of an adverse fetal outcome according t…

Commentary Open

Christopher M Florkowski · 2016

Koenzym Q10 i zastoinowa niewydolność serca: zmieniające się dowody naukowe Open

Christopher M Florkowski, Sarah L. Molyneux, Joanna M. Young · 2015

Familial dysalbuminaemic hyperthyroxinaemia: a rapid and novel mass spectrometry approach to diagnosis Open

Joshua Ryan, Stephen O. Brennan, Howard Potter, Louise Wolmarans, Christopher M Florkowski , et al. · 2015

Background Familial dysalbuminaemic hyperthyroxinaemia is an important cause of discordant thyroid function test results (due to an inherited albumin variant); however, the diagnosis can be challenging. A 51-year-old man had persistently e…

Preanalytical Variables and Alzheimer Disease Biomarker Concentrations in Cerebrospinal Fluid Open

Christopher M Florkowski · 2015

Cerebrospinal fluid (CSF)2 β-amyloid (Aβ1–42) is one of the key biological forms of β-amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1). Reductions in CSF…

Coenzyme Q10 and congestive heart failure; an evolving evidence base Open

Christopher M Florkowski, Sarah L. Molyneux, Joanna M. Young · 2015

Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment Open

Babak Rad, Mohamed Saleem, Susan Grant, Christopher M Florkowski, Penelope Coates , et al. · 2015

We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluorid…

Christopher M Florkowski YOU? Author Swipe