Christopher M. Proctor
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View article: Ultra‐Thin Soft Pneumatic Actuation for Minimally Invasive Neural Interfacing
Ultra‐Thin Soft Pneumatic Actuation for Minimally Invasive Neural Interfacing Open
Soft‐robotic fluidic actuation allows dynamic control of the shape and position of ultra‐flexible bioelectronic implants inside the body. While several actuation approaches have been proposed, all face significant limitations preventing cl…
Laser Micromachining for Bioelectronics: Past, Present, and Future Open
Laser micromachining has emerged over the last decade as a practical alternative to costly, complex photolithography, and to low‐resolution printing, for the manufacture of myriad bioelectronic devices. Here, the introduction and developme…
View article: Dynamically autofocused 3D pulsed laser micromachining enables advanced 3D bioelectronics
Dynamically autofocused 3D pulsed laser micromachining enables advanced 3D bioelectronics Open
Advancing next-generation bioelectronic interfaces requires devices that are soft, miniaturized, and seamlessly integrated with biological tissues. However, conventional fabrication methods, primarily based on UV photolithography, struggle…
High Dynamic Range Thin‐Film Resistive Flow Sensors for Monitoring Diverse Biofluids Open
Monitoring biofluid flow can serve as an important indicator for understanding physiological conditions, detecting diseases, and evaluating therapeutic responses. However, existing flow sensors suffer from rigid designs, large sizes, non‐b…
Thick conducting polymer films for ultra-low frequency stimulation Open
Conducting polymers like poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) offer the possibility of improving the electrochemical performance of bioelectronic and biomedical devices beyond what conventional electrode mate…
Wireless Power and Data Transfer Technologies for Flexible Bionic and Bioelectronic Interfaces: Materials and Applications Open
The next‐generation bionics and, more specifically, wearable and implantable bioelectronics require wireless, battery‐free, long‐term operation and seamless bio‐integration. Design considerations, materials choice, and implementation of ef…
View article: NeuroRoots, a bio-inspired, seamless brain machine interface for long-term recording in delicate brain regions
NeuroRoots, a bio-inspired, seamless brain machine interface for long-term recording in delicate brain regions Open
Scalable electronic brain implants with long-term stability and low biological perturbation are crucial technologies for high-quality brain–machine interfaces that can seamlessly access delicate and hard-to-reach regions of the brain. Here…
View article: Circadian clocks in human cerebral organoids
Circadian clocks in human cerebral organoids Open
Summary Circadian rhythms result from cell-intrinsic timing mechanisms that impact health and disease 1,2 . To date, however, neural circadian research has largely focused on the hypothalamic circuitry of nocturnal rodents 3 . Whether circ…
Publisher's Note: “Finite element analysis of electric field distribution during direct current stimulation of the spinal cord: Implications for device design” [APL Bioeng. <b>7</b>, 046109 (2023)] Open
[This corrects the article DOI: 10.1063/5.0163264.].
Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery Open
The concept of targeted and controlled drug delivery, which directs treatment to precise anatomical sites, offers benefits such as fewer side effects, reduced toxicity, optimized dosages, and quicker responses. However, challenges remain t…
Finite element analysis of electric field distribution during direct current stimulation of the spinal cord: Implications for device design Open
Spinal cord injury (SCI) arises from damage to the spinal cord, often caused by trauma or disease. The resulting sensorimotor dysfunction is variable and dependent on the extent of the injury. Despite years of research, curative options fo…
View article: 3D Bioelectronics with a Remodellable Matrix for Long‐Term Tissue Integration and Recording
3D Bioelectronics with a Remodellable Matrix for Long‐Term Tissue Integration and Recording Open
Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long‐term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates a foreign …
3D Bioelectronics with a Remodellable Matrix for Long-term Tissue Integration and Recording Open
Bioelectronics hold the key for understanding and treating disease. However, achieving stable, long-term interfaces between electronics and the body remains a challenge. Implantation of a bioelectronic device typically initiates a foreign …
View article: X‐Ray Markers for Thin Film Implants
X‐Ray Markers for Thin Film Implants Open
Implantable electronic medical devices are used in functional mapping of the brain before surgery and to deliver neuromodulation for the treatment of neurological and neuropsychiatric disorders. Their electrode arrays are assembled by hand…
Front Matter Open
Introduction to Bioelectronics: Materials, Devices, and Applications is a timely overview of this emerging field and focuses on foundational principles. It explores primary applications and provides current insights for bioelectronics inte…
Introduction Open
Bioelectronics is the field that involves the development of electronic interfaces with main objective to monitor or modulate biological processes. This introductory chapter provides background on electrical signalling in biology and gives…
Fluidic enabled bioelectronic implants: opportunities and challenges Open
Fluidics are enabling new possibilities in bioelectronic medicine and research.
Electronics with shape actuation for minimally invasive spinal cord stimulation Open
Electronics that change shape inside the body enable keyhole surgery of spinal implants that can treat severe pain.
Reducing Passive Drug Diffusion from Electrophoretic Drug Delivery Devices through Co‐Ion Engineering Open
Implantable electrophoretic drug delivery devices have shown promise for applications ranging from treating pathologies such as epilepsy and cancer to regulating plant physiology. Upon applying a voltage, the devices electrophoretically tr…
Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis Open
Local drug delivery directly to the source of a given pathology using retrodialysis is a promising approach to treating otherwise untreatable diseases. As the primary material component in retrodialysis, the semipermeable membrane represen…
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice Open
Epilepsy is a group of neurological disorders which affects millions of people worldwide. Although treatment with medication is helpful in 70% of the cases, serious side effects affect the quality of life of patients. Moreover, a high perc…
View article: NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording
NeuroRoots, a bio-inspired, seamless Brain Machine Interface device for long-term recording Open
Minimally invasive electrodes of cellular scale that approach a bio-integrative level of neural recording could enable the development of scalable brain machine interfaces that stably interface with the same neural populations over long pe…
Balance Between Light Absorption and Recombination Losses in Solution‐Processed Small Molecule Solar Cells with Normal or Inverted Structures Open
Comparison of the photovoltaic properties of F3:fullerene bulk heterojunction solar cells (where F3 is a donor molecule of intermediate dimensions) with normal and inverted structures as a function of photoactive layer thickness is carried…
Electrophoretic drug delivery for seizure control Open
An implantable microfluidic ion pump prevents seizures in a mice by delivery of inhibitory neurotransmitters to the seizure source.
Monitoring Intrinsic Optical Signals in Brain Tissue with Organic Photodetectors Open
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Orientation selectivity with organic photodetectors and an organic electrochemical transistor Open
Neuroinspired device architectures offer the potential of higher order functionalities in information processing beyond their traditional microelectronic counterparts. Here we demonstrate a neuromorphic function of orientation selectivity,…
Understanding volumetric capacitance in conducting polymers Open
Recent measurements in poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) films show that capacitance scales with film volume. We discuss the ramifications of this finding and propose a simple model that describes capacit…