Joanne Ryan
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View article: The Effect of Treating Hearing Loss with Hearing Aids on Plasma Biomarkers of Alzheimer's Disease and Related Dementias
The Effect of Treating Hearing Loss with Hearing Aids on Plasma Biomarkers of Alzheimer's Disease and Related Dementias Open
Background: Promising evidence indicates that treating hearing loss with hearing aids (HAs) could reduce dementia risk. We extend this evidence by investigating the effect of HAs on plasma biomarkers of Alzheimer's disease and related deme…
View article: Do music-related leisure activities influence cardiovascular disease risk, blood pressure and heart rate in older adults?
Do music-related leisure activities influence cardiovascular disease risk, blood pressure and heart rate in older adults? Open
View article: Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes
Late-life, visit-to-visit blood pressure variability and its association with sex-specific long-term cognitive outcomes Open
In 19 114 community-dwelling older adults enrolled in the ASPREE trial, high late-life visit-to-visit blood pressure variability (BPV) was associated with increased risks of incident dementia and cognitive decline during the median 4.7 yea…
View article: Feasibility, safety and efficacy of OsteoStrong® in postmenopausal women with low bone mineral density: A pilot study
Feasibility, safety and efficacy of OsteoStrong® in postmenopausal women with low bone mineral density: A pilot study Open
OsteoStrong® is a brief, near-isometric loading exercise modality that targets bone health improvements by applying forces at relevant anatomical sites using specific equipment during ∼10-min, once weekly sessions. Evidence on adherence, s…
View article: Enhancing Workplace Nutrition: Development of a Culturally-tailored Nutrition Intervention Program to Improve Dietary Patterns, Habits, Nutrition Literacy, and Health Outcomes
Enhancing Workplace Nutrition: Development of a Culturally-tailored Nutrition Intervention Program to Improve Dietary Patterns, Habits, Nutrition Literacy, and Health Outcomes Open
View article: Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study
Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study Open
Background Grip strength and gait speed are key markers of physical functional capacity and general health in older people. This study aimed to examine the effect of low-dose aspirin on handgrip strength and habitual gait speed in relative…
View article: Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study
Aspirin and healthy lifespan in older people: main outcome of the ASPREE-XT observational study Open
National Institute on Aging and the National Cancer Institute (USA).
View article: Long‐Term Blood Pressure Variability and Physical Performance in Older Adults
Long‐Term Blood Pressure Variability and Physical Performance in Older Adults Open
High variability in long‐term blood pressure (BPV) independently predicts cardiovascular disease and cognitive decline. Increased BPV and declining physical performance may share mechanistic pathways. However, associations of BPV with gait…
View article: The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial
The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial Open
Background Chronic low-grade inflammation is hypothesised as a central driver of frailty. This study aims to evaluate whether low-dose aspirin can reverse frailty status among initially prefrail/frail older adults. Methods This was a post …
View article: The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults
The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults Open
Background Retinal vessel calibres (RVCs) are non-invasive markers of microvascular health and may serve as accessible indicators of cerebral small vessel disease (CSVD) and future cognitive impairment. This study examines whether RVCs are…
View article: Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults
Moderate Alcohol Consumption and Risk of Depression: A Longitudinal Analysis in Community-Dwelling Older Adults Open
Background/Objectives: Evidence suggests a J-shaped association between alcohol consumption and depression, but it remains unclear whether this reflects a true causal effect, reverse causation, or methodological bias. This uncertainty is p…
View article: Genetic Variants, Metabolic Dysfunction-Associated Fatty Liver Disease, and Major Health Outcomes in Older Adults
Genetic Variants, Metabolic Dysfunction-Associated Fatty Liver Disease, and Major Health Outcomes in Older Adults Open
Background and Aims: Multiple genetic variants have been associated with disease prevalence and outcomes in middle-aged people with metabolic dysfunction-associated fatty liver disease (MAFLD). However, genetic studies in older adults have…
View article: Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis
Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis Open
Background Serum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of …
View article: Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort
Cognitive trajectories and incident atrial fibrillation in the ASPREE cohort Open
Background Atrial fibrillation (AF) is associated with aging and increased risk of stroke and dementia. We examined the association between incident AF and cognitive trajectories in older adults using longitudinal data from the ASPirin in …
View article: Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial Open
Background and Aims Guidelines recommend against routine initiation of low-dose aspirin in older adults for primary prevention of atherosclerotic cardiovascular disease events. This study aimed to estimate long-term and post-trial effects …
View article: From the ASPREE investigators: Response to Wittes et al.
From the ASPREE investigators: Response to Wittes et al. Open
View article: Social determinants of health clusters and risk of cardiovascular disease among community-dwelling older men and women: A clustering and causal machine learning approach
Social determinants of health clusters and risk of cardiovascular disease among community-dwelling older men and women: A clustering and causal machine learning approach Open
The study highlights the interconnectedness of SDoH and their greater impact on women's CVD risk compared to men.
View article: Steatotic Liver Disease in Older Adults: Clinical Implications and Unmet Needs
Steatotic Liver Disease in Older Adults: Clinical Implications and Unmet Needs Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the commonest cause of chronic liver disease worldwide. Its incidence has been increasing rapidly, alongside the growing epidemics of type 2 diabetes mellitus and overweig…
View article: Prevalence and outcomes of steatotic liver disease subtypes in older adults
Prevalence and outcomes of steatotic liver disease subtypes in older adults Open
Background: Steatotic liver disease (SLD) is a significant cause of chronic liver disease. However, the relative prevalence and prognostic significance of various disease entities according to recently defined classification systems (MAFLD…
View article: Frailty Risk After a Cardiovascular Event Among Community-Dwelling Older People: Influence of Sociodemographic, Polypharmacy, and Pre-event Frailty
Frailty Risk After a Cardiovascular Event Among Community-Dwelling Older People: Influence of Sociodemographic, Polypharmacy, and Pre-event Frailty Open
Our community-based study provides robust evidence that individuals who were women, older, pre-frail, with polypharmacy, and living in regional or remote areas have a markedly greater odds of developing frailty after a CVD event.
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View article: Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide
Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide Open
View article: Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians
Incidence of major health events across metropolitan and regional areas: A 10+ year prospective study of 16,697 older Australians Open
Objective To examine the prevalence of health risk factors by rurality status and the association of rurality and incidence of disability‐free survival (DFS), its components (death, dementia and physical disability), cardiovascular disease…
View article: Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults
Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults Open
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This…
View article: Scores to predict steatotic liver disease – correlates and outcomes in older adults
Scores to predict steatotic liver disease – correlates and outcomes in older adults Open
View article: Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults
Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults Open
View article: Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age
Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age Open
INTRODUCTION This study examined whether the waist circumference–body mass index ratio (WBR), lean body mass (LBM), and fat body mass (FBM) were associated with dementia or cognitive change. METHODS We analyzed data from >17,000 individual…
View article: Contribution of depression and cardiometabolic diseases and the role of depression treatment in survival and functioning in older adults
Contribution of depression and cardiometabolic diseases and the role of depression treatment in survival and functioning in older adults Open
View article: The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation
The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation Open
Background Longitudinal cohort studies across the lifespan suggest an association between ultra-processed food (UPF) and depression. However, the effect of UPF on depression and mental health in older adults has not been determined. Theref…
View article: Integrating Social Determinants of Health and Established Risk Factors to Predict Cardiovascular Disease Risk Among Healthy Older Adults
Integrating Social Determinants of Health and Established Risk Factors to Predict Cardiovascular Disease Risk Among Healthy Older Adults Open
Background Recent evidence underscores the significant impact of social determinants of health (SDoH) on cardiovascular disease (CVD). However, available CVD risk assessment tools often neglect SDoH. This study aimed to integrate SDoH with…