Christopher M. Sande
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View article: ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders
ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders Open
Telomere biology disorders (TBDs) are genetic diseases caused by defective telomere maintenance. TBD patients often develop bone marrow failure and have an increased risk of myeloid neoplasms. To better understand the factors underlying he…
View article: High-resolution melting assay for rapid, simultaneous detection of <i>JAK2</i>, <i>MPL</i> and <i>CALR</i> variants
High-resolution melting assay for rapid, simultaneous detection of <i>JAK2</i>, <i>MPL</i> and <i>CALR</i> variants Open
Aims Identification of recurrent genetic alterations in JAK2 , MPL and CALR remains crucial in the diagnosis of Philadelphia-negative myeloproliferative neoplasms (MPNs). Current laboratory testing algorithms may entail batching and/or seq…
View article: Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature
Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature Open
We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being espe…
View article: Angiographic Diagnosis of a Meckel's Diverticulum in a 26‐month‐old Boy
Angiographic Diagnosis of a Meckel's Diverticulum in a 26‐month‐old Boy Open
A 26-month-old boy presented with recurrent hematochezia. Abdominal examination was normal. Laboratory findings showed hemoglobin of 7.5 g/dL. Abdominal ultrasound (US) for intussusception revealed a short (0.3 cm) segment of wall thickeni…
View article: Impact of the Survey of Inhibitors in Plasma‐Product Exposed Toddlers (SIPPET) study and its post hoc analyses on clinical practice in the United States: A survey of Haemophilia and Thrombosis Research Society members
Impact of the Survey of Inhibitors in Plasma‐Product Exposed Toddlers (SIPPET) study and its post hoc analyses on clinical practice in the United States: A survey of Haemophilia and Thrombosis Research Society members Open
Introduction A recent randomized trial, the Survey of Inhibitors in Plasma‐Product Exposed Toddlers (SIPPET), confirmed that exposure to recombinant FVIII (rFVIII) products doubled the risk of inhibitor development compared to plasma‐deriv…
View article: Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats
Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats Open
A diverse array of G protein-coupled receptors (GPCRs) is implicated in the modulation of nociception. The efficacy and potency of several GPCR agonists change as a consequence of peripheral inflammatory injury. Whether these changes refle…