Christopher M. Wintersinger
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View article: Reusing excess staple oligonucleotides for economical production of DNA origami
Reusing excess staple oligonucleotides for economical production of DNA origami Open
DNA origami has enabled the development of responsive drug-delivery vehicles with precision features that were previously not attainable in bionanotechnology. To reduce the costs of creating therapeutic-scale amounts of DNA origami that ne…
View article: Reusing excess staple oligonucleotides for economical production of DNA origami
Reusing excess staple oligonucleotides for economical production of DNA origami Open
DNA origami has enabled the development of responsive drug-delivery vehicles with precision features that were previously not attainable in bionanotechnology. To reduce the costs of creating therapeutics-scale amounts of DNA origami that n…
View article: Author Correction: Multi-micron crisscross structures grown from DNA-origami slats
Author Correction: Multi-micron crisscross structures grown from DNA-origami slats Open
View article: Multi-micron crisscross structures grown from DNA-origami slats
Multi-micron crisscross structures grown from DNA-origami slats Open
View article: Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination
Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination Open
Multivalent presentation of ligands often enhances receptor activation and downstream signaling. DNA origami offers precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanoparticles. Here we introduce a “squa…
View article: Multi-micron crisscross structures from combinatorially assembled DNA-origami slats
Multi-micron crisscross structures from combinatorially assembled DNA-origami slats Open
Living systems achieve robust self-assembly across length scales. Meanwhile, nanofabrication strategies such as DNA origami have enabled robust self-assembly of submicron-scale shapes.However, erroneous and missing linkages restrict the nu…
View article: Robust nucleation control via crisscross polymerization of highly coordinated DNA slats
Robust nucleation control via crisscross polymerization of highly coordinated DNA slats Open
Natural biomolecular assemblies such as actin filaments or microtubules can exhibit all-or-nothing polymerization in a kinetically controlled fashion. The kinetic barrier to spontaneous nucleation arises in part from positive cooperativity…
View article: Robust nucleation control via crisscross polymerization of DNA slats
Robust nucleation control via crisscross polymerization of DNA slats Open
Natural biomolecular assemblies such as actin filaments or microtubules polymerize in a nucleation-limited fashion 1,2 . The barrier to nucleation arises in part from chelate cooperativity, where stable capture of incoming monomers require…