Christopher Ma
YOU?
Author Swipe
View article: Placebo rates in randomised clinical trials of ulcerative colitis: An individual patient data meta-analysis
Placebo rates in randomised clinical trials of ulcerative colitis: An individual patient data meta-analysis Open
Background and aims We assessed placebo rates and associated factors using individual patient data (IDP) from randomised clinical trials (RCTs) in ulcerative colitis (UC). Methods We conducted an IPD meta-analysis using Vivli and Yale Univ…
View article: Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project
Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project Open
View article: Addition of Baseline Histology and Fecal Calprotectin Does Not Reduce Placebo Rates in Ulcerative Colitis Clinical Trials: Post-hoc Analysis of Patient Level Data
Addition of Baseline Histology and Fecal Calprotectin Does Not Reduce Placebo Rates in Ulcerative Colitis Clinical Trials: Post-hoc Analysis of Patient Level Data Open
Background Placebo response rates in ulcerative colitis (UC) trials are highly variable. It is uncertain whether adding objective measures of inflammation, such as fecal calprotectin (FC) or histologic activity, to conventional eligibility…
View article: An international consensus on the design of clinical trials for advanced combination treatment (ACT) in inflammatory bowel disease
An international consensus on the design of clinical trials for advanced combination treatment (ACT) in inflammatory bowel disease Open
None.
View article: Refractory Immune Checkpoint Inhibitor Colitis Treated With Biologics, Janus Kinase Inhibition, Plasma Exchange, and Fecal Microbiota Transplantation
Refractory Immune Checkpoint Inhibitor Colitis Treated With Biologics, Janus Kinase Inhibition, Plasma Exchange, and Fecal Microbiota Transplantation Open
Enterocolitis is a common immune-related adverse event associated with cancer immunotherapy. Current guidelines inform first-line pharmacologic management of immune checkpoint inhibitor-related enterocolitis; however, treatment in refracto…
View article: Pharmacological management of upper gastrointestinal Crohn’s disease: a systematic review
Pharmacological management of upper gastrointestinal Crohn’s disease: a systematic review Open
Background Upper gastrointestinal Crohn’s disease (UGICD) is an uncommon phenotype with limited management guidelines. We reviewed evidence on the safety and efficacy of pharmacological interventions for UGICD. Methods We searched MEDLINE,…
View article: Spatial transcriptomics reveals unique inflammatory signatures across all anatomic locations in postoperative Crohn’s disease
Spatial transcriptomics reveals unique inflammatory signatures across all anatomic locations in postoperative Crohn’s disease Open
Background and Aims Most patients with Crohn’s disease (CD) who have undergone ileocolonic resection experience recurrent inflammation within 1 year after surgery. We examined the molecular basis underlying gastrointestinal inflammation in…
View article: Research progress on the inhibitory effect of bioactive components of cactus on diabetes
Research progress on the inhibitory effect of bioactive components of cactus on diabetes Open
View article: Navigating Care Amid Crisis: The Impact of the COVID-19 Pandemic on Eosinophilic Esophagitis Management in Canada
Navigating Care Amid Crisis: The Impact of the COVID-19 Pandemic on Eosinophilic Esophagitis Management in Canada Open
Background and Objectives: The COVID-19 pandemic caused significant disruptions in healthcare services. Foreign body impactions (FBIs), with Eosinophilic Esophagitis (EoE) being one of the leading underlying causes in adults, are some of t…
View article: Integrating Intestinal Ultrasound to Clinical Trials in Patients With Crohn’s Disease: Opportunities and Challenges
Integrating Intestinal Ultrasound to Clinical Trials in Patients With Crohn’s Disease: Opportunities and Challenges Open
This narrative review summarizes the current knowledge on using intestinal ultrasonography (IUS) to evaluate disease activity in patients with Crohn’s disease (CD) and explores its potential role in clinical trials. Current trial endpoints…
View article: Comparative Safety of JAK Inhibitors vs TNF Antagonists in Immune-Mediated Inflammatory Diseases
Comparative Safety of JAK Inhibitors vs TNF Antagonists in Immune-Mediated Inflammatory Diseases Open
Importance Janus kinase (JAK) inhibitors are highly effective medications for several immune-mediated inflammatory diseases (IMIDs). However, safety concerns have led to regulatory restrictions. Objective To compare the risk of adverse eve…
View article: Adalimumab around the world: comparative analysis of products characteristics and patient support systems
Adalimumab around the world: comparative analysis of products characteristics and patient support systems Open
Following the expiration of the adalimumab originator patent, there has been a rapid increase in the availability and uptake of adalimumab biosimilars. While chemically and clinically similar in effects, there are substantial non-pharmacol…
View article: Impact of Concomitant Corticosteroid Use on Adverse Events in Ulcerative Colitis Clinical Trials
Impact of Concomitant Corticosteroid Use on Adverse Events in Ulcerative Colitis Clinical Trials Open
Background and aims Adverse events (AEs) are frequently reported in clinical trials of advanced therapies for ulcerative colitis (UC). It remains uncertain whether patients receiving concomitant corticosteroids experience higher AE rates. …
View article: Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases
Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases Open
Background: Mucosal histological activity is increasingly valued as a treatment endpoint in inflammatory bowel diseases (IBD). In the Asia Pacific region, the utility and acceptability of IBD histology as a treatment endpoint are uncertain…
View article: Disease burden, diagnosis pathways and treatment patterns in patients with eosinophilic esophagitis: a real-world study
Disease burden, diagnosis pathways and treatment patterns in patients with eosinophilic esophagitis: a real-world study Open
Background Despite a rising prevalence of eosinophilic esophagitis (EoE), real-world data on current management challenges remain limited. Objective To evaluate demographic and clinical characteristics, treatment patterns, and health outco…
View article: Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project
Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project Open
Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that effects both pediatrics and adult patients in Canada and is increasing in prevalence. No Canadian focused best practice recommendations curre…
View article: A framework for clinical care pathway renewal: an example from inflammatory bowel disease
A framework for clinical care pathway renewal: an example from inflammatory bowel disease Open
View article: Recent innovations in clinical trial design for inflammatory bowel disease
Recent innovations in clinical trial design for inflammatory bowel disease Open
Clinical trial design in inflammatory bowel disease (IBD) is evolving to address challenges in drug development and approvals. For clinical development, notable innovations include Bayesian designs, adaptive designs, integrated-phase trial…
View article: Development and External Validation of an Endoscopic and Histologic Pouchitis Assessment Tool: The Atlantic Pouchitis Index
Development and External Validation of an Endoscopic and Histologic Pouchitis Assessment Tool: The Atlantic Pouchitis Index Open
Development and validation of the API advances pouchitis disease assessment. Integration of endoscopy and histopathology results in an objective, reliable, and responsive instrument to evaluate therapy effectiveness in research and clinica…
View article: Expert Position Statement: Defining the Role of Intestinal Ultrasound in Assessing Constipation and Faecal Loading
Expert Position Statement: Defining the Role of Intestinal Ultrasound in Assessing Constipation and Faecal Loading Open
Background Intestinal ultrasound has been proposed as a tool to assess non‐inflammatory functional gastrointestinal disorders, including constipation and faecal loading. However, well‐defined sonographic criteria for these conditions are c…
View article: Clinical application of expanded carrier screening based on next-generation sequencing in the Chinese population
Clinical application of expanded carrier screening based on next-generation sequencing in the Chinese population Open
View article: Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis
Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis Open
Background Fibrostenosis is a serious complication of eosinophilic oesophagitis, but there is a lack of consensus regarding its definition and assessment. This poses a barrier in clinical care and research. Aim To perform a systematic revi…
View article: Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease
Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease Open
The high sensitivity of fecal calprotectin (<50 μg/g) and cross-sectional imaging can help reduce the need for invasive and costly colonoscopy monitoring for CD recurrence after surgery. Applying optimal definitions of sonographic recurren…
View article: Metabolism and response to stress gene signatures reveal ulcerative colitis heterogeneity and identify patients with increased response to therapy
Metabolism and response to stress gene signatures reveal ulcerative colitis heterogeneity and identify patients with increased response to therapy Open
Background and Aims Ulcerative colitis (UC) therapies lead to variable remission and response rates in patients participating in clinical trials, likely due to interindividual target variability, differences in active biological pathways, …
View article: An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease
An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease Open
These recommendations will serve to optimize trial design and facilitate appropriate, acceptable, and standardized RCT corticosteroid handling practices.
View article: Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response
Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response Open
View article: A220 LONG-TERM EFFECTIVENESS AND SAFETY OF USTEKINUMAB DOSE ESCALATION IN PATIENTS WITH REFRACTORY ULCERATIVE COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY
A220 LONG-TERM EFFECTIVENESS AND SAFETY OF USTEKINUMAB DOSE ESCALATION IN PATIENTS WITH REFRACTORY ULCERATIVE COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY Open
Background Ustekinumab dose escalation (DE) may be an effective strategy to recapture clinical response in patients with ulcerative colitis (UC). Aims The aim of this study was to assess the real-world long-term effectiveness and safety of…
View article: A94 ASSOCIATION OF BOWEL URGENCY WITH OTHER DISEASE ACTIVITY MEASURES IN ULCERATIVE COLITIS
A94 ASSOCIATION OF BOWEL URGENCY WITH OTHER DISEASE ACTIVITY MEASURES IN ULCERATIVE COLITIS Open
Background The presence of bowel urgency and fecal incontinence negatively impacts quality of life in patients with ulcerative colitis (UC). Aims We aimed to characterize the assessment of urgency and incontinence in routine clinical care.…
View article: A221 GENERALIZABILITY OF RANDOMIZED CONTROLLED TRIALS TO ROUTINE CLINICAL CARE IN ULCERATIVE COLITIS
A221 GENERALIZABILITY OF RANDOMIZED CONTROLLED TRIALS TO ROUTINE CLINICAL CARE IN ULCERATIVE COLITIS Open
Background Historically, randomized controlled trials (RCTs) have been criticized for being poorly generalizable to patients with ulcerative colitis (UC) evaluated in routine care. Aims We aimed to evaluate the proportion of patients with …
View article: A154 TEMPORAL TRENDS OF DEPRESSION HOSPITALIZATION AND SUICIDE DEATH IN THOSE WITH INFLAMMATORY BOWEL DISEASE
A154 TEMPORAL TRENDS OF DEPRESSION HOSPITALIZATION AND SUICIDE DEATH IN THOSE WITH INFLAMMATORY BOWEL DISEASE Open
Background Individuals with inflammatory bowel disease (IBD) are known to be more susceptible to mental health disorders such as depression. However, literature examining severe outcomes of depression in IBD, including hospitalizations due…