Christopher MacIsaac
YOU?
Author Swipe
View article: Phenobarbital as an Adjuvant to benzodiazepine administration when compared to Single-agent benzodiazepine Treatment (usual care) for Alcohol Withdrawal Syndrome in the Intensive Care Unit (PASTA): a study protocol for a feasibility trial that embeds screening, enrolment and randomization within the electronic medical records
Phenobarbital as an Adjuvant to benzodiazepine administration when compared to Single-agent benzodiazepine Treatment (usual care) for Alcohol Withdrawal Syndrome in the Intensive Care Unit (PASTA): a study protocol for a feasibility trial that embeds screening, enrolment and randomization within the electronic medical records Open
Background Abrupt cessation of alcohol consumption following hospital admission can induce alcohol withdrawal syndrome. This syndrome is challenging to manage and is associated with considerable morbidity and mortality. Current management …
View article: The impact of red blood cells storage duration on the development of acute kidney injury: A secondary analysis of the <scp>TRANSFUSE</scp> multicenter randomized controlled trial
The impact of red blood cells storage duration on the development of acute kidney injury: A secondary analysis of the <span>TRANSFUSE</span> multicenter randomized controlled trial Open
Background Red blood cell (RBC) transfusion is associated with an increased risk of acute kidney injury (AKI). The extent to which RBC storage affects this association is unclear. We aimed to evaluate the association between storage durati…
View article: Feasibility of Embedding a Randomised Clinical Trial (RCT) into an Electronic Medical Record (EMR) for Patients Admitted to an Intensive Care Unit (ICU)
Feasibility of Embedding a Randomised Clinical Trial (RCT) into an Electronic Medical Record (EMR) for Patients Admitted to an Intensive Care Unit (ICU) Open
To establish the feasibility of embedding an RCT into EMR in the ICU, we evaluated the route of phosphate replacement. The EMR screened 207 patients who met the inclusion criteria from 20 April 2022 to 30 June 2022. 162 patients were rando…
View article: Burkholderia in ICU – a combined epidemiologic, genomic and engineering investigation
Burkholderia in ICU – a combined epidemiologic, genomic and engineering investigation Open
View article: Aggression, violence and threatening behaviour during critical illness
Aggression, violence and threatening behaviour during critical illness Open
The prevalence of Code Grey events in ICU appears to be increasing. Patients may have repeated events. Younger male patients admitted to ICU via the emergency department with a trauma or medical diagnosis are at greatest risk of a Code Gre…
View article: Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients
Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients Open
Importance Brain-computer interface (BCI) implants have previously required craniotomy to deliver penetrating or surface electrodes to the brain. Whether a minimally invasive endovascular technique to deliver recording electrodes through t…
View article: Communication with bereaved family members after death in the ICU: the CATHARTIC randomised clinical trial
Communication with bereaved family members after death in the ICU: the CATHARTIC randomised clinical trial Open
View article: A hospital-wide response to multiple outbreaks of COVID-19 in health care workers: Lessons learned from the field
A hospital-wide response to multiple outbreaks of COVID-19 in health care workers: Lessons learned from the field Open
View article: A microcosting analysis of ICU expenditure in the interval between brain death and organ donation
A microcosting analysis of ICU expenditure in the interval between brain death and organ donation Open
View article: Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial Open
View article: A hospital‐wide response to multiple outbreaks of <scp>COVID</scp> ‐19 in health care workers: lessons learned from the field
A hospital‐wide response to multiple outbreaks of <span>COVID</span> ‐19 in health care workers: lessons learned from the field Open
The response to the largest institutional outbreak of COVID-19 in health care workers in Australia to date needed to be multidimensional In many countries, high rates of health care workers with coronavirus disease 2019 (COVID-19) have bee…
View article: Knowledge, attitudes and practices of healthcare workers within an Australian tertiary hospital to managing high-consequence infectious diseases
Knowledge, attitudes and practices of healthcare workers within an Australian tertiary hospital to managing high-consequence infectious diseases Open
View article: Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience
Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience Open
Background Implantable brain–computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore voluntary motor impulses to control digital devices and improve functional independence in patients with severe pa…
View article: Successful implementation of a short message service (SMS) as intensive care to family communication tool
Successful implementation of a short message service (SMS) as intensive care to family communication tool Open
We successfully instituted real-time SMS updates. All surveyed participants agreed that these messages were reassuring, informative and easy to follow and that they would recommend the SMS service to other families.
View article: Quantifying Response to Nutrition Therapy During Critical Illness: Implications for Clinical Practice and Research? A Narrative Review
Quantifying Response to Nutrition Therapy During Critical Illness: Implications for Clinical Practice and Research? A Narrative Review Open
Critical illness causes substantial muscle loss that adversely impacts recovery and health‐related quality of life. Treatments are therefore needed that reduce mortality and/or improve the quality of survivorship. The purpose of this Revie…
View article: Review article: Let us talk about snakebite management: A discussion on many levels
Review article: Let us talk about snakebite management: A discussion on many levels Open
We want to discuss antivenom use in snakebite clinical practice guidelines. Coronial reviews in Victoria of two cases of snakebite envenomation, one described in detail below, prompted us to submit this paper for a wider audience and debat…
View article: Associations between nutritional energy delivery, bioimpedance spectroscopy and functional outcomes in survivors of critical illness
Associations between nutritional energy delivery, bioimpedance spectroscopy and functional outcomes in survivors of critical illness Open
Background Patients who survive critical illness frequently develop muscle weakness that can impact on quality of life; nutrition is potentially a modifiable risk factor. The present study aimed to explore the associations between cumulati…
View article: Intensive care implications of epidemic thunderstorm asthma
Intensive care implications of epidemic thunderstorm asthma Open
Arrival of a triggering storm is associated with an increase in respirable airborne particles. Affected critically ill patients are young, have a high mortality, a short duration of bronchospasm, and a prior diagnosis of asthma is common.
View article: The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors
The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors Open
View article: Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial)
Targeted full energy and protein delivery in critically ill patients: a study protocol for a pilot randomised control trial (FEED Trial) Open
View article: Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis
Intensity of early correction of hyperglycaemia and outcome of critically ill patients with diabetic ketoacidosis Open
In a large cohort of patients with DKA, partial early correction of BGL according to DKA-specific guidelines, when compared with intensive early correction of BGL, was independently associated with a lower risk of hypoglycaemia, hypo-osmol…
View article: Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability
Validation of a classification system for causes of death in critical care: an assessment of inter-rater reliability Open
The ICU-DECLARE system allowed ICU doctors to classify the proximate cause of death of patients who died in the ICU with substantial reliability.
View article: Outcomes of decompressive craniectomy in patients after traumatic brain injury
Outcomes of decompressive craniectomy in patients after traumatic brain injury Open
DC decreased ICP postoperatively. The IMPACT and APACHE II scores are good models for prediction of death and poor outcome at 6 months.