Christopher J. Ng
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View article: Correction: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells
Correction: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells Open
[This corrects the article DOI: 10.1371/journal.pone.0298133.].
View article: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells
Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells Open
Alterations in von Willebrand factor (VWF) have an important role in human health and disease. Deficiency of VWF is associated with symptoms of bleeding and excesses of VWF are associated with thrombotic outcomes. Understanding the mechani…
View article: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA
Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA Open
These data are in the .prism format and represent the imaging, qPCR, and ELISA of the siRNA and CRISPR data in this manuscript. Western blot is in TIFF format.
View article: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA
Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA Open
These data are in the .prism format and represent the imaging, qPCR, and ELISA of the siRNA and CRISPR data in this manuscript. Western blot is in TIFF format.
View article: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA
Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA Open
These data are in the .prism format and represent the imaging, qPCR, and ELISA of the siRNA and CRISPR data in this manuscript. Western blot is in TIFF format.
View article: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA
Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells - DATA Open
These data are in the .prism format and represent the imaging, qPCR, and ELISA of the siRNA and CRISPR data in this manuscript.
View article: A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia
A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia Open
This report identifies a novel variant form of the inherited bleeding disorder Glanzmann thrombasthenia, exhibiting only mild bleeding in a physically active individual. The platelets cannot aggregate ex vivo with physiologic agonists of a…
View article: Quantitative analysis of Weibel-Palade bodies
Quantitative analysis of Weibel-Palade bodies Open
Weibel Palade bodies (WPBs) are vesicles found in endothelial cells which carry the multimeric protein von Willebrand factor (VWF). As cellular confluency has been shown to influence the number of WPBs in endothelial cells, we propose to t…
View article: Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels
Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels Open
von Willebrand factor (VWF) plays a key role in normal hemostasis, and deficiencies of VWF lead to clinically significant bleeding. We sought to identify novel modifiers of VWF levels in endothelial colony-forming cells (ECFCs) using singl…
View article: Supplementary Material for: Improvements in Communication and Coordination of Care in a Hemophilia Treatment Center
Supplementary Material for: Improvements in Communication and Coordination of Care in a Hemophilia Treatment Center Open
Introduction: In response to the increasing complexity of care for patients with bleeding disorders, we established new clinical teams for our hemophilia treatment center (HTC). Aims: We undertook a quality improvement project to improve t…