Explanipedia

EXTH-37. Evaluating cell state-targeting CAR-T cells in glioblastoma Open

Sophia Kovatsis, Christopher Mount, Emily Boxer, Jun Zhong, Sydney Dumont , et al. · 2025

Despite decades of concerted research and clinical efforts, patient outcomes in glioblastoma (GBM) remain dismal. While chimeric antigen receptor (CAR)- T cell therapies in GBM have produced individual reports of efficacy, they have yet to…

IMMU-38. Single-cell RNA sequencing of cerebrospinal fluid in CARv3-TEAM-E treated glioblastoma Open

Demi Gerovasilis, Christopher Mount, Md. Raihan Chowdhury, Kathleen Gallagher, Mario L. Suvà · 2025

Glioblastoma is a highly aggressive primary brain tumor in adults with limited treatment options. Although there has been continuing interest in employing the immune system to combat this disease, monoclonal antibody therapies, such as che…

Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1 Open

Shawn Gillespie, Yoon Seok Kim, Anna C. Geraghty, Belgin Yalçın, Rebecca Mancusi , et al. · 2025

Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity 1–5 that functions as a paracrine …

A single-cell atlas of Schwannoma across genetic backgrounds and anatomic locations Open

L. Nicolas Gonzalez Castro, Avishai Gavish, Lillian Bussema, Christopher Mount, Cyril Neftel , et al. · 2025

Overall, our atlas describes the spectrum of gene expression across schwannoma entities at the single-cell level and will serve as an important resource for the community.

Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages Open

Alexander T. Hary, Sarabjit Chadha, Nathaniel D. Mercaldo, Evan N. Smith, André van der Kouwe , et al. · 2025

The locus coeruleus (LC) has been identified as a site that develops phosphorylated tau pathology earlier than cerebral cortex. We present data using high-resolution postmortem MRI and validated tau histopathology in controls and the earli…

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip Open

John J. Y. Lee, Ran Tao, Zhen You, Parthiv Haldipur, Anders W. Erickson , et al. · 2025

Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recur…

The Impact of TERT Promoter Mutation on Meningioma Outcome is Context-Dependent: Implications for Clinical Grading and Risk Stratification Open

Karenna J. Groff, Ruchit V. Patel, Yang Feng, Hia S. Ghosh, Miguel A. Millares Chavez , et al. · 2025

NFS-09.<i>NF1</i> MUTATION IN OLIGODENDROCYTE PRECURSOR CELLS LEADS TO PRENEOPLASTIC LESION FORMATION IN THE BRAIN Open

Yuan Pan, Jared Hysinger, Belgin Yalçın, James Lennon, Youkyeong Gloria Byun , et al. · 2024

Oligodendrocyte precursor cells (OPCs) are progenitor cells that give rise to central nervous system oligodendrocytes throughout life. Transcriptomic and lineage tracing studies suggest that OPCs may be the putative cell of origin for many…

Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice Open

Yuan Pan, Jared Hysinger, Belgin Yalçın, James Lennon, Youkyeong Gloria Byun , et al. · 2024

Engineered CD47 protects T cells for enhanced antitumour immunity Open

Sean A. Yamada‐Hunter, Johanna Theruvath, Brianna J. McIntosh, Katherine A. Freitas, Frank Lin , et al. · 2024

Glioma spatialomics dataset Open

Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, L. Nicolas Gonzalez-Castro , et al. · 2024

Data related to the paper "Integrative spatial analysis reveals a multi-layered organization of glioblastoma" (Greenwald*, Galili-Darnell*, Hoefflin* et al., 2024. Cell 187(10): 2485-2501). See visium_dataset_description.csv and readme_COD…

Integrative spatial analysis reveals a multi-layered organization of glioblastoma Open

Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, Christopher Mount , et al. · 2024

Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of…

Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma Open

Bryan D. Choi, Elizabeth R. Gerstner, Matthew J. Frigault, Mark B. Leick, Christopher Mount , et al. · 2024

In this first-in-human, investigator-initiated, open-label study, three participants with recurrent glioblastoma were treated with CARv3-TEAM-E T cells, which are chimeric antigen receptor (CAR) T cells engineered to target the epidermal g…

Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma Open

Rebecca C. Larson, Michael C. Kann, Charlotte Graham, Christopher Mount, Ana P. Castaño , et al. · 2023

Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most patients do not achieve long-term complete remissions. In addition, recent evidence…

MODL-07. <i>NF1</i> MUTATION IN OLIGODENDROCYTE PRECURSOR CELLS INDUCES PRENEOPLASTIC LESIONS IN THE BRAIN Open

Yuan Pan, Jared Hysinger, Belgin Yalçın, James Lennon, Preethi Raghavan , et al. · 2023

Oligodendrocyte precursor cells (OPCs) are progenitor cells that give rise to oligodendrocytes in the central nervous system throughout the lifespan. Transcriptomic and lineage tracing studies suggest that OPCs may be the putative cell of …

Integrative spatial analysis reveals a multi-layered organization of glioblastoma Open

Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, L. Nicolas Gonzalez-Castro , et al. · 2023

Summary Glioma contains malignant cells in diverse states. Hypoxic regions are associated with a unique histology of pseudopalisading cells, while other regions appear to have limited histological organization, reflecting the diffuse natur…

Glioma spatialomics dataset Open

Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, L. Nicolas Gonzalez-Castro , et al. · 2023

See visium_dataset_description.csv and readme_CODEX.txt Thirteen fresh frozen GBM samples profiled by 10x Visium Six fresh frozen IDH mutant samples profiled by 10x Visium Twelve fresh frozen GBM samples profiled by CODEX

Engineered CD47 protects T cells for enhanced antitumor immunity Open

Sean A. Yamada‐Hunter, Johanna Theruvath, Brianna J. McIntosh, Katherine A. Freitas, Molly Radosevich , et al. · 2023

Adoptively transferred T cells and agents designed to block the CD47/SIRPα axis are promising antitumor therapeutics, which activate distinct arms of the immune system. We administered anti-CD47 (αCD47) with adoptively transferred T cells …

Data from CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Open

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui , et al. · 2023

Purpose:Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatr…

Data from CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Open

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui , et al. · 2023

Purpose:Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatr…

Supplementary Data from CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Open

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui , et al. · 2023

Supplementary Figures

Supplementary Data from CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Open

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui , et al. · 2023

Supplementary Figures

Advances in Chimeric Antigen Receptor (CAR) T-Cell Therapies for the Treatment of Primary Brain Tumors Open

Christopher Mount, L. Nicolas Gonzalez Castro · 2022

Immunotherapy has revolutionized the care of cancer patients. A diverse set of strategies to overcome cancer immunosuppression and enhance the tumor-directed immune response are in clinical use, but have not achieved transformative benefit…

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas Open

Robbie G. Majzner, Sneha Ramakrishna, Kristen W. Yeom, Shabnum Patel, Harshini Chinnasamy , et al. · 2022

Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system 1 . We have previously shown that the disialoganglioside GD2 is highly …

IMMU-55. GD2 IS A MACROPHAGE CHECKPOINT MOLECULE AND COMBINED GD2/CD47 BLOCKADE RESULTS IN SYNERGISTIC EFFECTS AGAINST GD2 POSITIVE MALIGNANCIES Open

Johanna Theruvath, Christopher Mount, Michelle Monje, Crystal L. Mackall, Robbie G. Majzner · 2020

GD2 is a disialoganglioside expressed on a variety of tumors including DIPG, neuroblastoma and osteosarcoma. Anti-GD2 antibodies have demonstrated some success in neuroblastoma and they have either not proven to be effective or have not be…

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors Open

Johanna Theruvath, Elena Sotillo, Christopher Mount, Claus Moritz Graef, Alberto Delaidelli , et al. · 2020

Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival…

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity Open

Christopher Mount, Belgin Yalçın, Kennedy Cunliffe-Koehler, Shree Sundaresh, Michelle Monje · 2019

Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, …

Author response: Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity Open

Christopher Mount, Belgin Yalçın, Kennedy Cunliffe-Koehler, Shree Sundaresh, Michelle Monje · 2019

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity Open

Christopher Mount, Belgin Yalçın, Kennedy Cunliffe-Koehler, Michelle Monje · 2019

Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC afferents, …

CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors Open

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui , et al. · 2019

Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediat…

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