Christopher P. Larsen
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View article: High-Fidelity CRISPR-Cas12a–Based Apolipoprotein L1 Genotyping
High-Fidelity CRISPR-Cas12a–Based Apolipoprotein L1 Genotyping Open
Key Points A protospacer adjacent motif sequence is not required for CRISPR-Cas12a–mediated cis-cleavage of apolipoprotein L1 risk allele sequences. Discrimination of both single-nucleotide and insertion/deletion variants can be accurately…
View article: Spectrum of Kidney Pathology in Patients With Syphilis
Spectrum of Kidney Pathology in Patients With Syphilis Open
A spectrum of kidney pathology diagnoses is seen in patients with syphilis, with the majority of patients presenting with AKI. Coinfections, and pathology related to coinfections, were common.
View article: Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use
Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use Open
Drugs are an important secondary cause of membranous nephropathy (MN) with the most common drugs associated with MN being nonsteroidal anti-inflammatory drugs (NSAIDs). Since the target antigen in NSAID-associated MN is not known, we perfo…
View article: Serologic Studies in Membranous Nephropathy: Novel Strategies and Strengthened Associations
Serologic Studies in Membranous Nephropathy: Novel Strategies and Strengthened Associations Open
Introduction Serologic studies have transformed clinical practice for patients with phospholipase A2 receptor (PLA2R)-positive membranous nephropathy (MN) by enabling noninvasive therapeutic disease monitoring. Although it is well known th…
View article: Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry Open
Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, antigenic targets of disease are unknown for over 10% of patients with MN and over half of those with membranous lupus nephritis…
View article: Characteristics of Renal Intravascular Large B-cell Lymphoma
Characteristics of Renal Intravascular Large B-cell Lymphoma Open
Kidney IVLBCL is a rare disease that is unexpectedly diagnosed by kidney biopsy, presenting with fever, anemia, mild AKI, and proteinuria. Median survival is 21 months and extrarenal involvement is associated with worse outcome.
View article: “You can't touch, you can't bond”: Exploring COVID‐19 pandemic impacts on rheumatoid arthritis patient goals and communication with clinicians
“You can't touch, you can't bond”: Exploring COVID‐19 pandemic impacts on rheumatoid arthritis patient goals and communication with clinicians Open
The rapid shift to telehealth during the COVID-19 pandemic changed how patients and clinicians interact and communicate (Srinivasan et al., 2020). Effective patient-clinician communication is essential to support shared decision making (SD…
View article: EXT1 and NCAM1-associated membranous lupus nephritis in a cohort of patients undergoing repeat kidney biopsies
EXT1 and NCAM1-associated membranous lupus nephritis in a cohort of patients undergoing repeat kidney biopsies Open
Background Exostosin 1/2 (EXT1/2) and neural cell adhesion molecule 1 (NCAM1) associated membranous lupus nephritis (MLN) may represent distinct disease phenotypes with prognostic significance. Methods We searched our archives for patients…
View article: APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19
APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19 Open
Background and objectives Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the APOL1 are responsible for a portion of this higher risk. We so…
View article: Immunoglobulin-Negative Fibrillary Glomerulonephritis Masked in Diabetic Nephropathy: A Case Report and Discussion of a Diagnostic Pitfall
Immunoglobulin-Negative Fibrillary Glomerulonephritis Masked in Diabetic Nephropathy: A Case Report and Discussion of a Diagnostic Pitfall Open
Introduction: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease with poor prognosis, characterized by deposition of randomly arranged fibrillar material measuring 10–30 nm in diameter. This diagnosis is confirmed with DNAJB9…
View article: Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy Open
Key Points TGF- β receptor 3 (TGFBR3) staining identifies a novel type of membranous nephropathy (MN). TGFBR3-associated MN is enriched in patients with membranous lupus nephritis with similar characteristics as exostosin 1/2- and neural c…
View article: Membranous nephropathy in a patient with coronavirus disease 2019 (COVID-19): A case report
Membranous nephropathy in a patient with coronavirus disease 2019 (COVID-19): A case report Open
Although the MN could be incidental, this observation raises the question of whether SARS-CoV-2 infection can trigger or worsen an underlying MN from an exaggerated immune response associated with COVID-19.
View article: COVID-19–Associated Nonocclusive Fibrin Microthrombi in the Heart
COVID-19–Associated Nonocclusive Fibrin Microthrombi in the Heart Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant clinical presentation, coronavirus disease 2019 (COVID-19), is an emergent cause of mortality worldwide. Cardiac complications secondary to this inf…
View article: Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis
Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis Open
Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with systemic lupus erythematosus. It has been shown in phospholipase A2 receptor positive membranous nephropathy that known antibodies can be detected within…
View article: Characteristics of patients with coexisting DNAJB9-associated fibrillary glomerulonephritis and IgA nephropathy
Characteristics of patients with coexisting DNAJB9-associated fibrillary glomerulonephritis and IgA nephropathy Open
Background Coexistence of fibrillary glomerulonephritis (FGN) and immunoglobulin A (IgA) nephropathy (IgAN) in the same kidney biopsy (FGN–IgAN) is rare, and the clinicopathologic characteristics and outcome of this dual glomerulopathy are…
View article: NELL1 is a target antigen in malignancy-associated membranous nephropathy
NELL1 is a target antigen in malignancy-associated membranous nephropathy Open
Patients with membranous nephropathy have an increased risk of malignancy compared to the general population, but the target antigen for malignancy-associated membranous nephropathy is unknown. To explore this, we utilized mass spectrometr…