Christopher P. Toret
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View article: Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism Open
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex conserved in all domains of life. However,…
View article: Mosaic evolution of clathrin-mediated endocytosis in fungi
Mosaic evolution of clathrin-mediated endocytosis in fungi Open
Clathrin-mediated endocytosis is an ancient eukaryotic trafficking pathway, which transports plasma membrane and associated cargo into the cell and is involved in numerous cell- and tissue-level processes. Cargo selection and clathrin-coat…
View article: Evolutionarily diverged on-switch for actin assembly in fungal endocytosis
Evolutionarily diverged on-switch for actin assembly in fungal endocytosis Open
Clathrin-mediated endocytosis is a conserved eukaryotic trafficking process where an Arp2/3 complex nucleated branched actin network provides force for vesicle formation. The mechanisms that initiate endocytic actin assembly are incomplete…
View article: An evolutionary cell biology perspective into the diverging mechanisms of clathrin-mediated endocytosis in dikarya fungi
An evolutionary cell biology perspective into the diverging mechanisms of clathrin-mediated endocytosis in dikarya fungi Open
Clathrin-mediated endocytosis is an ancient eukaryotic trafficking pathway, which transports plasma membrane and associated cargo into the cell and is involved in numerous cell- and tissue-level processes. Cargo selection and clathrin-coat…
View article: Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis
Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis Open
The capping of barbed filament ends is a fundamental mechanism for actin regulation. Capping protein controls filament growth and actin turnover in cells by binding to the barbed ends of the filaments with high affinity and slow off-rate. …
View article: Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis
Bsp1, a fungal CPI motif protein, regulates actin filament capping in endocytosis and cytokinesis Open
The capping of barbed filament ends is a fundamental mechanism for actin regulation. Capping protein controls filament growth and actin turnover in cells by binding to the barbed ends of the filaments with high affinity and slow off-rate. …
View article: The cellular slime mold Fonticula alba forms a dynamic, multicellular collective while feeding on bacteria
The cellular slime mold Fonticula alba forms a dynamic, multicellular collective while feeding on bacteria Open
View article: A dynamic multicellularity emerges for collective invasion within opisthokonta
A dynamic multicellularity emerges for collective invasion within opisthokonta Open
Raw data used for the quantification of the Fonticula Collective behaviours : https://github.com/apicco/Fonticula_collective_invasion
View article: A dynamic multicellularity emerges for collective invasion within opisthokonta
A dynamic multicellularity emerges for collective invasion within opisthokonta Open
Raw data used for the quantification of the Fonticula Collective behaviours : https://github.com/apicco/Fonticula_collective_invasion
View article: Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
Specialization of actin isoforms derived from the loss of key interactions with regulatory factors Open
View article: Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
Specialization of actin isoforms derived from the loss of key interactions with regulatory factors Open
A paradox of eukaryotic cells is that while some species assemble a complex actin cytoskeleton from a single ortholog, other species utilize a greater diversity of actin isoforms. The physiological consequences of using different actin iso…
View article: A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions
A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions Open
The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP wer…
View article: Coupling of Rho family GTPases during mesenchymal-to-epithelial-like transitions
Coupling of Rho family GTPases during mesenchymal-to-epithelial-like transitions Open
Many metazoan developmental processes require cells to transition between migratory mesenchymal- and adherent epithelial-like states. These transitions require Rho GTPase-mediated actin rearrangements downstream of integrin and cadherin pa…