Christopher Pinelli
YOU?
Author Swipe
View article: Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner
Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner Open
Hypoxia is a common feature in tumors and induces signaling that promotes tumor cell survival, invasion, and metastasis, but the impact of hypoxia inducible factor (HIF) signaling in the primary tumor on dissemination to bone in particular…
View article: Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model
Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model Open
Decompensated right ventricular failure (RVF) in patients with pulmonary hypertension (PH) is fatal, with limited treatment options. Novel mechanical circulatory support systems have therapeutic potential for RVF, but the development of th…
View article: Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers
Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers Open
Given their genetic and anatomic similarities to humans, nonhuman primates (NHPs) may serve as animal models for urogenital diseases of humans. The purpose of this study was to examine the frequency of spontaneous urogenital lesions occurr…
View article: Spontaneous Pituitary Adenomas in Squirrel Monkeys (<i>Saimiri sciureus</i>)
Spontaneous Pituitary Adenomas in Squirrel Monkeys (<i>Saimiri sciureus</i>) Open
On postmortem examination, 2 geriatric captive male squirrel monkeys ( Saimiri sciureus ) were found to have pituitary masses that were unassociated with previous experimental manipulation. Both animals were euthanized due to apparently un…
View article: Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors
Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors Open
Marine-derived n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to inhibit mammary carcinogenesis. However, evidence regarding plant-based α-linolenic acid (ALA), …
View article: Long Term Physiologic and Behavioural Effects of Housing Density and Environmental Resource Provision for Adult Male and Female Sprague Dawley Rats
Long Term Physiologic and Behavioural Effects of Housing Density and Environmental Resource Provision for Adult Male and Female Sprague Dawley Rats Open
There is considerable interest in refining laboratory rodent environments to promote animal well-being, as well as research reproducibility. Few studies have evaluated the long term impact of enhancing rodent environments with resources an…
View article: Role of Macrophages in the Development of Castration-Resistant Prostate Cancer
Role of Macrophages in the Development of Castration-Resistant Prostate Cancer Open
Prostate cancer (PCa) is the second most common cancer affecting men in Canada and USA, and accounts for thousands of deaths each year. While most prostate tumours are considered localized disease at initial diagnosis and can be treated wi…