Christopher R. Chin
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View article: Figures S1-S7 from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
Figures S1-S7 from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas Open
Gating strategies, validation of results using alternative models or definitions, QC controls, etc.
View article: Table S1 from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
Table S1 from An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas Open
Supplementary Table S1 - Differentially expressed genes and PAGE analysis in Myd88 L252P GCB
View article: A splicing regulator, SR45, suppresses plant immunity by regulating salicylic acid pathway in Arabidopsis thaliana
A splicing regulator, SR45, suppresses plant immunity by regulating salicylic acid pathway in Arabidopsis thaliana Open
Facing constant challenges from various pathogens and pests, plants have evolved different strategies to defend themselves both locally and systemically. A global change in RNA metabolism is one of the necessary steps to mount a long-lasti…
View article: Wild-type p53 overexpression in <i>NPM1</i>-mutated acute myeloid leukemia: potential implications for disease biology and therapy response
Wild-type p53 overexpression in <i>NPM1</i>-mutated acute myeloid leukemia: potential implications for disease biology and therapy response Open
Not available.
View article: Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells
Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells Open
We present DynaVelo, a generative neural ordinary differential equation (ODE) model that learns the joint dynamics of gene expression and transcription factor (TF) motif activities in evolving cell systems using single-cell multiome data. …
View article: Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility Open
View article: Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology Open
View article: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility Open
Identifying cell-type-specific 3D chromatin interactions between regulatory elements can help decipher gene regulation and interpret disease-associated non-coding variants. However, achieving this resolution with current 3D genomics techno…
View article: Wild-Type p53 Overexpression in NPM1-Mutated AML: Potential Implications for Disease Biology and Therapy Response
Wild-Type p53 Overexpression in NPM1-Mutated AML: Potential Implications for Disease Biology and Therapy Response Open
Somatic mutations in nucleophosmin (NPM1) are key in defining a common subtype of acute myeloid leukemia (NPM1-AML), characterized by chromosomal stability and favorable therapeutic responses. However, some patients exhibit a suboptimal re…
View article: Figure S4 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S4 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Hypoxic memory exists in certain breast cancer cells
View article: Table S1 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S1 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
List of genes downregulated in BRx68 cells grown in hypoxia for 8 weeks
View article: Figure S1 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S1 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
In vitro and in vivo growth of CTC lines influenced by different oxygen culture conditions
View article: Figure S2 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S2 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
In vivo breast tumors show inverse correlation between hypoxia and IFN/AP gene signatures
View article: Figure S8 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S8 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Hypoxic memory of tumor cells and immune profiles of NT2.5 syngeneic tumors
View article: Table S7 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S7 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Genes belonging to the hypoxia and IFN/AP signatures
View article: Data from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Data from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Hypoxia is a common feature of many solid tumors due to aberrant proliferation and angiogenesis that is associated with tumor progression and metastasis. Most of the well-known hypoxia effects are mediated through hypoxia-inducible factors…
View article: Figure S6 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S6 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Evaluation of epigenetic reasons for hypoxic downregulation of IFN/AP signal
View article: Figure S3 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S3 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Hypoxia suppression of IFN/AP lasts longer than the hypoxic exposure
View article: Table S4 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S4 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
GSEA analysis with genes upregulated in 68H compared to 68N
View article: Figure S9 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S9 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Immune cell analysis of NT2.5 syngeneic tumors and PyMT tumors
View article: Table S2 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S2 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
List of genes upregulated in BRx68 cells grown in hypoxia for 8 weeks
View article: Table S5 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S5 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
GSEA analysis with genes upregulated in responders compared to non-responders
View article: Figure S7 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S7 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Hypoxia-tracing reporter system showed tumor cells with hypoxic memory and enhanced metastatic capacity
View article: Figure S5 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Figure S5 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
Evaluation of stimulus, response, and HIF for hypoxic downregulation of IFN/AP signal
View article: Table S6 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S6 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
GSEA analysis with genes downregulated in responders compared to non-responders
View article: Table S3 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression
Table S3 from Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression Open
GSEA analysis with genes downregulated in 68H compared to 68N
View article: Spatiotemporal expression and control of haemoglobin in space
Spatiotemporal expression and control of haemoglobin in space Open
It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, wi…
View article: A second space age spanning omics, platforms and medicine across orbits
A second space age spanning omics, platforms and medicine across orbits Open
View article: Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight Open
As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) …
View article: Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight Open
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found …