Christopher R. L. Large
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View article: Variation in Social Feeding Behaviors and Interactions Among <i>Caenorhabditis Nematodes</i>
Variation in Social Feeding Behaviors and Interactions Among <i>Caenorhabditis Nematodes</i> Open
The ability to respond to stimuli and environmental cues is essential for higher order organisms to survive and reproduce and requires a neuronal network that can integrate cues and execute behavioral responses. Evolution of behaviors occu…
View article: Lineage-resolved analysis of embryonic gene expression evolution in <i>C. elegans</i> and <i>C. briggsae</i>
Lineage-resolved analysis of embryonic gene expression evolution in <i>C. elegans</i> and <i>C. briggsae</i> Open
The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous cells. The conserved invariant embryoni…
View article: Lineage-resolved analysis of embryonic gene expression evolution in<i>C. elegans</i>and<i>C. briggsae</i>
Lineage-resolved analysis of embryonic gene expression evolution in<i>C. elegans</i>and<i>C. briggsae</i> Open
What constraints govern the evolution of gene expression patterns across development remains a fundamental question of evolutionary biology. The advent of single-cell sequencing opens the possibility of learning these constraints by system…
View article: Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA
Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA Open
Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain t…
View article: Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA
Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA Open
Inherited and de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generat…
View article: yEvo: experimental evolution in high school classrooms selects for novel mutations that impact clotrimazole resistance in <i>Saccharomyces cerevisiae</i>
yEvo: experimental evolution in high school classrooms selects for novel mutations that impact clotrimazole resistance in <i>Saccharomyces cerevisiae</i> Open
Antifungal resistance in pathogenic fungi is a growing global health concern. Nonpathogenic laboratory strains of Saccharomyces cerevisiae are an important model for studying mechanisms of antifungal resistance that are relevant to underst…
View article: Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors
Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors Open
The hippocampus is associated with essential brain functions, such as learning and memory. Human hippocampal volume is significantly greater than expected compared with that of non-human apes, suggesting a recent expansion. Intermediate pr…
View article: Directed evolution as an approach to increase fructose utilization in synthetic grape juice by wine yeast AWRI 796
Directed evolution as an approach to increase fructose utilization in synthetic grape juice by wine yeast AWRI 796 Open
In winemaking, slow or stuck alcoholic fermentation can impact processing efficiency and wine quality. Residual fructose in the later stages of fermentation can leave the wine ‘out of specification’ unless removed, which requires reinocula…
View article: Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors
Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors Open
The hippocampus is associated with essential brain functions such as learning and memory. Human hippocampal volume is significantly greater than expected when compared to non-human apes, suggesting a recent expansion. Intermediate progenit…
View article: yEvo: Experimental evolution in high school classrooms selects for novel mutations and epistatic interactions that impact clotrimazole resistance in<i>S. cerevisiae</i>
yEvo: Experimental evolution in high school classrooms selects for novel mutations and epistatic interactions that impact clotrimazole resistance in<i>S. cerevisiae</i> Open
Antifungal resistance in pathogenic fungi is a growing global health concern. Non-pathogenic laboratory strains of Saccharomyces cerevisiae are a useful model for studying mechanisms of antifungal resistance that are relevant to understand…
View article: Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery
Genomic stability and adaptation of beer brewing yeasts during serial repitching in the brewery Open
Ale brewing yeast are the result of admixture between diverse strains of Saccharomyces cerevisiae , resulting in a heterozygous tetraploid that has since undergone numerous genomic rearrangements. As a result, comparisons between the genom…
View article: Temperature preference can bias parental genome retention during hybrid evolution
Temperature preference can bias parental genome retention during hybrid evolution Open
Interspecific hybridization can introduce genetic variation that aids in adaptation to new or changing environments. Here, we investigate how hybrid adaptation to temperature and nutrient limitation may alter parental genome representation…
View article: Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of <i>Saccharomyces cerevisiae</i>
Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of <i>Saccharomyces cerevisiae</i> Open
The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA varia…
View article: Phenotypic and genotypic consequences of CRISPR/Cas9 editing of the replication origins in the rDNA of <i>Saccharomyces cerevisiae</i>
Phenotypic and genotypic consequences of CRISPR/Cas9 editing of the replication origins in the rDNA of <i>Saccharomyces cerevisiae</i> Open
The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, and thus, the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA …
View article: Temperature preference biases parental genome retention during hybrid evolution
Temperature preference biases parental genome retention during hybrid evolution Open
Interspecific hybridization can introduce genetic variation that aids in adaptation to new or changing environments. Here we investigate how the environment, and more specifically temperature, interacts with hybrid genomes to alter parenta…