Christopher Randolph
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View article: Who Learns from City Games? Examining the Role of Motivation, Personality, and Experience
Who Learns from City Games? Examining the Role of Motivation, Personality, and Experience Open
The growing popularity of escape rooms has led to the emergence of various adaptations of the escape game concept (The Economist, 2019). One such variation is the city game, which extends the escape game format by distributing puzzles thro…
View article: Large language models for closed-library multi-document query, test generation, and evaluation
Large language models for closed-library multi-document query, test generation, and evaluation Open
Introduction Learning complex, detailed, and evolving knowledge is a challenge in multiple technical professions. Relevant source knowledge is contained within many large documents and information sources with frequent updates to these doc…
View article: Operationalizing selection criteria for clinical trials in Alzheimer's disease: Biomarker and clinical considerations: Proceedings from the Alzheimer's Association Research Roundtable (AARR) Fall 2021 meeting
Operationalizing selection criteria for clinical trials in Alzheimer's disease: Biomarker and clinical considerations: Proceedings from the Alzheimer's Association Research Roundtable (AARR) Fall 2021 meeting Open
The design of clinical trials in Alzheimer's disease (AD) must consider the development of new plasma, cerebrospinal fluid (CSF), and imaging biomarkers. They must also define clinically meaningful outcomes for patients and set endpoints t…
View article: The Utility of Study Insight Analytics (SIA) Algorithms in Identifying Scoring Error Risks in the Clinical Dementia Rating scale (CDR)
The Utility of Study Insight Analytics (SIA) Algorithms in Identifying Scoring Error Risks in the Clinical Dementia Rating scale (CDR) Open
Background Clinical trials in Alzheimer’s Disease (AD) suffer from high failure rates, in part due to imprecision in endpoint measurements that introduces noise 1 . SIA is a quantitative approach that utilizes algorithms to identify incons…
View article: Summary of the 2015 University of Michigan Sport Concussion Summit
Summary of the 2015 University of Michigan Sport Concussion Summit Open
Discussions surrounding concussion have made their way into the public sphere over the previous decade with media attention and coverage of the injury fueling public debate. These conversations have devolved into discussions on banning con…
View article: Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition
Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition Open
Objectives: To examine the effects of 10 weeks feeding of low and high isoflavones levels in soy protein concentrate after 8 weeks on casein (CAS) as control diet on protection against Non-Alcoholic Fatty Liver Disease (NAFLD) and determin…
View article: Impact of Independent Review on Potential MMSE Score Inflation at Screening in AD trials
Impact of Independent Review on Potential MMSE Score Inflation at Screening in AD trials Open
Background The Mini‐Mental State Examination (MMSE) is widely used as a screening tool in Alzheimer’s Disease (AD) clinical trials. Screening score inflation is documented in clinical trials of depression and anxiety. We investigated wheth…
View article: Impact of rater change on data variability in ADAS‐Cog and CDR assessments
Impact of rater change on data variability in ADAS‐Cog and CDR assessments Open
Background The past decade has seen numerous research trial failures in Alzheimer’s Disease. The CDR and ADAS‐Cog are the two most frequently used primary outcome measures of memory and cognition in clinical trials of Alzheimer’s Disease (…
View article: Operationalizing selection criteria for clinical trials in Alzheimer's disease: Biomarker and clinical considerations
Operationalizing selection criteria for clinical trials in Alzheimer's disease: Biomarker and clinical considerations Open
Alzheimer's disease (AD) staging criteria lack standardized, empirical description. Well‐defined AD staging criteria are an important consideration in protocol design, influencing a more standardized inclusion/exclusion criteria and defini…
View article: Cross‐sectional and longitudinal assessments of function in prodromal‐to‐mild Alzheimer's disease: A comparison of the ADCS‐ADL and A‐IADL‐Q scales
Cross‐sectional and longitudinal assessments of function in prodromal‐to‐mild Alzheimer's disease: A comparison of the ADCS‐ADL and A‐IADL‐Q scales Open
Introduction Prior observational work in a heterogeneous cohort of participants with mild cognitive impairment suggests the Amsterdam Instrumental Activities of Daily Living Questionnaire (A‐IADL‐Q) may have greater sensitivity for functio…
View article: Progression from Prodromal Alzheimer’s Disease to Mild Alzheimer’s Disease Dementia in the Verubecestat APECS Study: Adjudicating Diagnostic Transitions
Progression from Prodromal Alzheimer’s Disease to Mild Alzheimer’s Disease Dementia in the Verubecestat APECS Study: Adjudicating Diagnostic Transitions Open
Background: Delay of progression from prodromal Alzheimer’s disease (AD) to dementia is an important outcome in AD trials. Centralized adjudication is intended to improve the consistency of dementia diagnosis but has not been scrutinized. …
View article: Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model
Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model Open
Obesity is the leading cause of health-related diseases in the United States and World. Previously, we reported that obesity can change gut microbiota using the Zucker rat model. Metformin is an oral anti-hyperglycemic agent approved by th…
View article: Sensitivity of the Preclinical Alzheimer's Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer's Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial
Sensitivity of the Preclinical Alzheimer's Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer's Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial Open
Cross-sectional relationships between Aβ and cognition among clinically unimpaired older adults are detectable on multi-domain cognitive composites but are relatively small in magnitude. The Aβ+/- group effect was statistically larger for …
View article: Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency
Low IgG trough and lymphocyte subset counts are associated with hospitalization for COVID-19 in patients with primary antibody deficiency Open
View article: Prevalence and Characterization of Mild Cognitive Impairment in Retired National Football League Players
Prevalence and Characterization of Mild Cognitive Impairment in Retired National Football League Players Open
It has been hypothesized that exposure to repetitive head trauma from contact sports over a long-playing career may eventuate in an increased risk of late-life cognitive impairment. There are currently two competing hypotheses about the po…
View article: Building clinically relevant outcomes across the Alzheimer's disease spectrum
Building clinically relevant outcomes across the Alzheimer's disease spectrum Open
Demonstrating that treatments are clinically meaningful across the Alzheimer's disease (AD) continuum is critical for meeting our goals of accelerating a cure by 2025. While this topic has been a focus of several Alzheimer's Association Re…
View article: Asthma and the Risk of Invasive Pneumococcal Disease: A Meta-Analysis
Asthma and the Risk of Invasive Pneumococcal Disease: A Meta-Analysis Open
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View article: Work Group Report: Perspectives in Diagnosis and Management of Exercise-Induced Bronchoconstriction in Athletes
Work Group Report: Perspectives in Diagnosis and Management of Exercise-Induced Bronchoconstriction in Athletes Open
View article: Preinjury somatization symptoms contribute to clinical recovery after sport-related concussion
Preinjury somatization symptoms contribute to clinical recovery after sport-related concussion Open
OBJECTIVE: To determine the degree to which preinjury and acute postinjury psychosocial and injury-related variables predict symptom duration following sport-related concussion. METHODS: A total of 2,055 high school and collegiate athletes…
View article: Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools (CNTs): Reliability and Validity for the Assessment of Sport-Related Concussion
Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools (CNTs): Reliability and Validity for the Assessment of Sport-Related Concussion Open
Limited data exist comparing the performance of computerized neurocognitive tests (CNTs) for assessing sport-related concussion. We evaluated the reliability and validity of three CNTs—ANAM, Axon Sports/Cogstate Sport, and ImPACT—in a comm…
View article: Age Differences in Recovery After Sport-Related Concussion: A Comparison of High School and Collegiate Athletes
Age Differences in Recovery After Sport-Related Concussion: A Comparison of High School and Collegiate Athletes Open
Younger age has been hypothesized to be a risk factor for prolonged recovery after sport-related concussion, yet few studies have directly evaluated age differences in acute recovery.
View article: A systematic review of potential long-term effects of sport-related concussion
A systematic review of potential long-term effects of sport-related concussion Open
Systematic review of possible long-term effects of sports-related concussion in retired athletes.
View article: Private Practice Experience with Omalizumab for Chronic Urticaria
Private Practice Experience with Omalizumab for Chronic Urticaria Open
View article: The pathway to secondary prevention of Alzheimer's disease
The pathway to secondary prevention of Alzheimer's disease Open
Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention …
View article: Composite neurocognitive endpoints in Alzheimer's disease clinical trials: A commentary
Composite neurocognitive endpoints in Alzheimer's disease clinical trials: A commentary Open
View article: Being Overweight or Obese and the Development of Asthma
Being Overweight or Obese and the Development of Asthma Open
Although adult obesity has been associated with 250 000 new cases of asthma annually, the authors attempted to associate overweight and obesity with incident asthma and attributable risk in pediatric asthma in the United States.Subjects we…
View article: Cognitive decline on the Repeatable Battery for the Assessment of Neuropsychological Status in progressive supranuclear palsy
Cognitive decline on the Repeatable Battery for the Assessment of Neuropsychological Status in progressive supranuclear palsy Open
Objective: Progressive supranuclear palsy (PSP) is associated with a variety of cognitive deficits, but few studies have reported on its cognitive trajectory across time, especially on the Repeatable Battery for the Assessment of Ne…
View article: FTS3‐01‐05: FURTHER ANALYSES OF COGNITIVE OUTCOMES IN THE APECS PHASE‐3 TRIAL OF VERUBECESTAT IN PRODROMAL AD
FTS3‐01‐05: FURTHER ANALYSES OF COGNITIVE OUTCOMES IN THE APECS PHASE‐3 TRIAL OF VERUBECESTAT IN PRODROMAL AD Open
In the phase-3 APECS trial, the BACE inhibitor verubecestat failed to improve clinical outcomes in participants with prodromal AD and was associated with worsening on some measures, notably cognition. Worsening relative to placebo was appa…
View article: P1‐473: CROSS‐CULTURAL APPLICABILITY OF THE REPEATABLE BATTERY FOR THE ASSESSMENT OF NEUROPSYCHOLOGICAL STATUS (RBANS) IN COGNITIVELY NORMAL SUBJECTS
P1‐473: CROSS‐CULTURAL APPLICABILITY OF THE REPEATABLE BATTERY FOR THE ASSESSMENT OF NEUROPSYCHOLOGICAL STATUS (RBANS) IN COGNITIVELY NORMAL SUBJECTS Open
Globally conducted Alzheimer's disease (AD) clinical trials depend upon neurocognitive performance measures free from cultural bias. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is an instrument that has b…
View article: Cognitive deficits in progressive supranuclear palsy on the Repeatable Battery for the Assessment of Neuropsychological Status
Cognitive deficits in progressive supranuclear palsy on the Repeatable Battery for the Assessment of Neuropsychological Status Open
Progressive supranuclear palsy (PSP) is associated with a variety of cognitive deficits, as well as motor and psychiatric disturbances. As clinical trials for PSP evolve, briefer screening instruments will be needed to determine cognitive …