Christopher Rongo
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View article: Analysis of categorical data from biological experiments with logistic regression and CMH tests
Analysis of categorical data from biological experiments with logistic regression and CMH tests Open
The choice of appropriate statistical tests in experimental biology is critical for scientific rigor and can be challenging in the case of categorical data analysis. Using example datasets from Caenorhabditis elegans research, we conduct s…
View article: Drug-induced metabolic remodeling of immune cell repertoire generates an effective broad-range antimicrobial effect
Drug-induced metabolic remodeling of immune cell repertoire generates an effective broad-range antimicrobial effect Open
Multiple mechanisms of immunity must be coordinated to defend against a comprehensive range of pathogens; however, the mechanisms by which broad-spectrum antipathogens act remain largely elusive. Here, we employed systems biology approache…
View article: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the Transforming Growth Factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: Analysis of Categorical Data with Logistic Regression and the Cochran–Mantel–Haenszel Tests in Biological Experiments
Analysis of Categorical Data with Logistic Regression and the Cochran–Mantel–Haenszel Tests in Biological Experiments Open
The choice of statistical test is a fundamentally important one when analyzing experimental data. Here, we consider the question of categorical data, defined by their properties (for example color) rather than by continuous numbering. Usin…
View article: Author response: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
Author response: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the Transforming Growth Factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the Transforming Growth Factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the transforming growth factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: Genome-wide analysis of Smad and Schnurri transcription factors in <i>C. elegans</i> demonstrates widespread interaction and a function in collagen secretion
Genome-wide analysis of Smad and Schnurri transcription factors in <i>C. elegans</i> demonstrates widespread interaction and a function in collagen secretion Open
Smads and their transcription factor partners mediate the transcriptional responses of target cells to secreted ligands of the Transforming Growth Factor-β (TGF-β) family, including those of the conserved bone morphogenetic protein (BMP) f…
View article: NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons
NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons Open
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-o…
View article: NEKL-4 regulates microtubule stability and mitochondrial health in<i>C. elegans</i>ciliated neurons
NEKL-4 regulates microtubule stability and mitochondrial health in<i>C. elegans</i>ciliated neurons Open
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-o…
View article: The Hypoxia Response Pathway Promotes PEP Carboxykinase Expression And Gluconeogenesis
The Hypoxia Response Pathway Promotes PEP Carboxykinase Expression And Gluconeogenesis Open
Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than oxidative phosphorylation to generate energy, a phenomenon termed “the Warburg effect 1 .” Constitutive activation of the Hypoxia Inducible Factor (HIF…
View article: FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation
FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation Open
Mitochondrial quality control (MQC) balances organelle adaptation and elimination, and mechanistic crosstalk between the underlying molecular processes affects subsequent stress outcomes. FUNDC1 (FUN14 domain containing 1) is a mammalian m…
View article: Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling
Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling Open
The epidermal growth factor receptor (EGFR) signaling is important for normal development, such as vulval development in Caenorhabditis elegans, and hyperactivation of the EGFR is often associated with cancer development. Our previous repo…
View article: Biogenic Amine Neurotransmitters Promote Eicosanoid Production And Protein Homeostasis
Biogenic Amine Neurotransmitters Promote Eicosanoid Production And Protein Homeostasis Open
Multicellular organisms use multiple pathways to restore protein homeostasis (proteostasis) in response to adverse physiological conditions, changing environment, and developmental aging. The nervous system can regulate proteostasis in dif…
View article: RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling
RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling Open
Axons must correctly reach their targets for proper nervous system function, although we do not fully understand the underlying mechanism, particularly for the first ‘pioneer’ axons. In C. elegans, AVG is the first neuron to extend an axon…
View article: RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans Open
Retrograde transport is a critical mechanism for recycling certain membrane cargo. Following endocytosis from the plasma membrane, retrograde cargo is moved from early endosomes to Golgi followed by transport (recycling) back to the plasma…
View article: The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons
The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons Open
Neurons are sensitive to low oxygen (hypoxia) and employ a conserved pathway to combat its effects. Here, we show that p38 MAP Kinase (MAPK) modulates this hypoxia response pathway in C. elegans. Mutants lacking p38 MAPK components pmk-1 o…
View article: Author response: The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons
Author response: The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Neurons are sensitive to low oxygen (hypoxia) a…