Christopher C. Rowe
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View article: External Validation of Joint Propagation Model‐Based Tau PET CenTauR units
External Validation of Joint Propagation Model‐Based Tau PET CenTauR units Open
Background The Joint Propagation Model (JPM)‐based CenTauR scale was recently introduced to harmonize tau‐PET quantification across different radiotracers. This study examined how CenTauR harmonization enhances the comparability of tau‐PET…
View article: External Validation of Joint Propagation Model‐Based Tau PET CenTauR units
External Validation of Joint Propagation Model‐Based Tau PET CenTauR units Open
Background The Joint Propagation Model (JPM)‐based CenTauR scale was recently introduced to harmonize tau‐PET quantification across different radiotracers. This study examined how CenTauR harmonization enhances the comparability of tau‐PET…
View article: Social and Ethical Aspects of Remote and Hybrid Care in the Special Allocation Scheme in general practice (SEARCH): A mixed methods feasibility study protocol
Social and Ethical Aspects of Remote and Hybrid Care in the Special Allocation Scheme in general practice (SEARCH): A mixed methods feasibility study protocol Open
Background Despite the growing body of research on remote primary care and access for (digitally) excluded groups, very little is known about care for patients who have been deliberately excluded from mainstream services. The ‘Special Allo…
Multivariate models using NULISAseq and plasma p‐tau217 for staging Alzheimer's disease Open
INTRODUCTION Plasma phospho‐tau217 (p‐tau217) has been shown to demonstrate equal performance to cerebrospinal fluid (CSF) to predict amyloid beta (Aβ) positivity. Although such high‐performing plasma tests provide confirmatory information…
View article: Alzheimer's disease outlook: controversies and future directions
Alzheimer's disease outlook: controversies and future directions Open
For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in randomised controlled trials. However, the …
View article: Revisiting Centiloids using AI
Revisiting Centiloids using AI Open
The Centiloid scale is the standard for Amyloid (Aβ) PET quantification, widely used in research, clinical settings, and trial stratification. However, variability between tracers and scanners remains a challenge. This study introduces Dee…
Alzheimer’s disease biological PET staging using plasma p217+tau Open
Background Plasma phospho-tau biomarkers, such as p217+tau, excel at identifying Alzheimer’s disease (AD) neuropathology. However, their ability to substitute for tau PET to identify AD biological stage is unclear. Methods Participants inc…
The relationship between genetic variation in Aquaporin-4, sleep quality measures and Alzheimer’s disease-related phenotypes. Open
Genetic variants within the Aquaporin-4 gene (AQP4) have been associated with Alzheimer’s disease (AD) diagnosis, rate of cognitive decline, and brain amyloid-β (Aβ) burden. Additionally, AQP4 variants have been reported to moderate the re…
PETRUS VICTORIUS AND ARISTOTLE'S <i>EUDEMIAN ETHICS</i> Open
This article reassesses the contribution of the late Renaissance scholar and teacher Petrus Victorius (Pier Vettori) to the reconstruction of the text of Aristotle's Eudemian Ethics , which has come down to us in what is often a highly cor…
DeepSUVR: Using temporal constraints to improve SUVR and Centiloid quantification Open
Background PET quantification using the Standardised Uptake Value Ratio (SUVR) relies on the availability of a robust reference region. Intrinsic noise, spill in, and specific binding in the reference region can impact the reliability of t…
Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel Open
Background Cognitive dysfunction is central to clinicopathological models of Alzheimer’s disease (AD). While AD prospective studies assess similar cognitive domains, the neuropsychological tests used vary between studies, limiting potentia…
View article: Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits
Cross‐cohort epigenome‐wide association study in Alzheimer’s disease risk and related traits Open
Background Epigenome‐wide association studies (EWAS) have identified multiple loci that are differentially methylated in Alzheimer’s disease (AD). However, for complex diseases such as AD, single methylation sites associated with disease a…
DeepSUVR: Using temporal constraints to improve SUVR and Centiloid quantification Open
Background PET quantification using the Standardised Uptake Value Ratio (SUVR) relies on the availability of a robust reference region. Intrinsic noise, spill in, and specific binding in the reference region can impact the reliability of t…
View article: Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation Open
Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this direction. Howev…
View article: Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation Open
Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer’s Association (AA) criteria for AD furthers this direction. Howe…
A novel method in myocardial injury risk stratification using intravenous fat emulsion as sole rapid preparation for unfasted patients to suppress myocardial 18F-fluorodeoxyglucose uptake for optimal cardiac PET imaging: a proof-of-concept randomized-crossover trial Open
Objectives Optimal imaging of ischemic or inflammed myocardium via 18 F-FDG PET imaging requires suppression of background carbohydrate metabolism in normal myocardium. Sole administration of intravenous lipid emulsion has not previously b…
View article: Plasma biomarkers in chronic single moderate–severe traumatic brain injury
Plasma biomarkers in chronic single moderate–severe traumatic brain injury Open
Blood biomarkers are an emerging diagnostic and prognostic tool that reflect a range of neuropathological processes following traumatic brain injury (TBI). Their effectiveness in identifying long-term neuropathological processes after TBI …
View article: Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model
Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model Open
INTRODUCTION Tau‐positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instr…
View article: Is Australia ready for the rollout of amyloid-targeting therapies for Alzheimer’s disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics
Is Australia ready for the rollout of amyloid-targeting therapies for Alzheimer’s disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics Open
Background New amyloid-targeting monoclonal antibody (mAb) therapies for Alzheimer’s disease (AD) are currently under review by the Therapeutic Goods Administration for use in Australia. Aims To determine the infrastructure, workforce and …
View article: Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease
Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease Open
These findings highlight the significant role of BF atrophy in the complex pathway linking Aβ to cognitive impairment in early stages of AD. Volumetric assessment of BF subregions could be essential in elucidating the relationships between…
View article: Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology
Prediction of future cognitive decline among cognitively unimpaired individuals using measures of soluble phosphorylated tau or tau tangle pathology Open
Plasma p-tau217 and Tau-PET are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In this head-to-head …
Conversion from mild cognitive impairment to Alzheimer's disease over 12 months: Predictive value of A beta imaging with 18F-Florbetaben Open
Conversion from mild cognitive impairment to Alzheimer's disease over 12 months: Predictive value of A beta imaging with 18F-Florbetaben
View article: Impact of PET Reconstruction on Amyloid-β Quantitation in Cross-Sectional and Longitudinal Analyses
Impact of PET Reconstruction on Amyloid-β Quantitation in Cross-Sectional and Longitudinal Analyses Open
Amyloid-β (Aβ) accumulation in Alzheimer disease (AD) is typically measured using SUV ratio and the centiloid (CL) scale. The low spatial resolution of PET images is known to degrade quantitative metrics because of the partial-volume effec…
Suboptimal self‐reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults Open
INTRODUCTION This study investigated whether self‐reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (m…