Christopher Schliehe
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View article: Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor response
Adoptive cell therapy using T cell receptors equipped with ICOS yields durable anti-tumor response Open
In adoptive cell therapy, longevity of effector T cells is challenged by the immune suppressive microenvironment of tumors, which often lacks co-stimulatory cues. To overcome this limitation, we have designed and tested next-generation T c…
View article: Supplementary Table 1 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Table 1 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Table 1
View article: Supplementary Table 3 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Table 3 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Table 3
View article: Supplementary Figure 3 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 3 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 3
View article: Supplementary Table 2 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Table 2 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Table 2
View article: Supplementary Figure 2 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 2 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 2
View article: Supplementary Figure 5 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 5 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 5
View article: Supplementary Figure 4 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 4 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 4
View article: Supplementary Figure 1 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 1 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 1
View article: Data from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Data from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Cytotoxic T lymphocytes screen cells for signs of infection and transformation by recognizing peptides displayed on MHC class I molecules. Next to canonical ATG-initiated open reading frames (ORF), noncanonical translation can result in sy…
View article: Supplementary Figure 7 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 7 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 7
View article: Supplementary Figure 6 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Figure 6 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Figure 6
View article: Supplementary Table 4 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
Supplementary Table 4 from CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Supplementary Table 4
View article: CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice Open
Cytotoxic T lymphocytes screen cells for signs of infection and transformation by recognizing peptides displayed on MHC class I molecules. Next to canonical ATG-initiated open reading frames (ORF), noncanonical translation can result in sy…
View article: Novel <i>STAT3</i> Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics
Novel <i>STAT3</i> Y360C Gain-of-function Variant Underlies Immune Dysregulation and Aberrancy in Mitochondrial Dynamics Open
The STAT3 is an important regulator in a wide range of different cell types. Human STAT3 variants are associated with several immune dysregulation diseases. The current study investigated the clinical, genetic, and immunobiological …
View article: 64P Gene-editing of T cells to provide resistance against macrophage-mediated suppression: Setting up an in vitro model
64P Gene-editing of T cells to provide resistance against macrophage-mediated suppression: Setting up an in vitro model Open
View article: 381 Co-stimulatory T cell receptors equipped with ICOS mediate durable anti-tumor activity
381 Co-stimulatory T cell receptors equipped with ICOS mediate durable anti-tumor activity Open
View article: TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model
TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model Open
Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies for the treatment of cancer; however, there remains a need to improve their efficacy. Determinants of ICB efficacy are the frequency of tumor mutations, …
View article: Challenges in developing personalized neoantigen cancer vaccines
Challenges in developing personalized neoantigen cancer vaccines Open
View article: Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere–Encapsulated Antigen and a Synthetic Long Peptide In Vitro
Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere–Encapsulated Antigen and a Synthetic Long Peptide In Vitro Open
The induction of CTL responses by vaccines is important to combat infectious diseases and cancer. Biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres and synthetic long peptides are efficiently internalized by professional APCs…
View article: A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models
A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models Open
Immunotherapies such as immune checkpoint blockade (ICB) therapies have been developed in the last years as a promising strategy for the treatment of cancer, however there remains a need to improve their efficacy. The most critical factor …
View article: Near-Infrared Bioluminescence Imaging of Macrophage Sensors for Cancer Detection In Vivo
Near-Infrared Bioluminescence Imaging of Macrophage Sensors for Cancer Detection In Vivo Open
Melanoma is an aggressive type of skin cancer with a poor prognosis after it gets metastasized. The early detection of malignant melanoma is critical for effective therapy. Because melanoma often resembles moles, routine skin check-up may …
View article: The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis Open
MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular mechanisms of MIR139 -silencing remain largely unknown. Here, we studied the poorly p…
View article: MicroRNA-155 Controls T Helper Cell Activation During Viral Infection
MicroRNA-155 Controls T Helper Cell Activation During Viral Infection Open
MicroRNA (miR) 155 has been implicated in the regulation of innate and adaptive immunity as well as autoimmune processes. Importantly, it has been shown to regulate several antiviral responses, but its contribution to the immune response a…
View article: Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules
Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules Open
Bifunctional degraders, also referred to as proteolysis-targeting chimeras (PROTACs), are a recently developed class of small molecules. They were designed to specifically target endogenous proteins for ubiquitin/proteasome-dependent degra…
View article: Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein Open
RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic…
View article: The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis
The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Open
View article: Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage Open