Christopher Schmied
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View article: Morphological profiling data resource enables prediction of chemical compound properties
Morphological profiling data resource enables prediction of chemical compound properties Open
Morphological profiling with the Cell Painting assay has emerged as a promising method in drug discovery research. The assay captures morphological changes across various cellular compartments enabling the rapid prediction of compound bioa…
View article: Nutrient-regulated control of lysosome function by signaling lipid conversion
Nutrient-regulated control of lysosome function by signaling lipid conversion Open
View article: Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology
Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology Open
View article: Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data
Semisupervised Contrastive Learning for Bioactivity Prediction Using Cell Painting Image Data Open
Morphological profiling has recently demonstrated remarkable potential for identifying the biological activities of small molecules. Alongside the fully supervised and self-supervised machine learning methods recently proposed for bioactiv…
View article: Semi-supervised Contrastive Learning for Bioactivity Prediction using Cell Painting Image Data
Semi-supervised Contrastive Learning for Bioactivity Prediction using Cell Painting Image Data Open
Morphological profiling has recently demonstrated remarkable potential for identifying the biological activities of small molecules. Alongside the fully supervised and self-supervised machine learning methods recently proposed for bioactiv…
View article: OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning
OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning Open
View article: Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines
Morphological Profiling Dataset of EU-OPENSCREEN Bioactive Compounds Over Multiple Imaging Sites and Cell Lines Open
Morphological profiling with the Cell Painting assay has emerged as a promising method in drug discovery research. The assay captures morphological changes across various cellular compartments enabling the rapid identification of the effec…
View article: OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning
OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning Open
Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for their function. For instance, the …
View article: Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P<sub>2</sub>
Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P<sub>2</sub> Open
Summary Mammalian cytokinesis critically depends on the phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ] which serves as docking site for crucial components of the cytokinetic machinery at the plasma membrane. PI(4,5)P 2 su…
View article: Nutrient-regulated control of lysosome function by signaling lipid conversion
Nutrient-regulated control of lysosome function by signaling lipid conversion Open
Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling and the catabolic turnover of macromolecules. How these janus-faced activities are regulated in response to cellular nutrient status is poorly unde…
View article: Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly Open
Neurons relay information via specialized presynaptic compartments for neurotransmission. Unlike conventional organelles, the specialized apparatus characterizing the neuronal presynapse must form de novo. How the components for presynapti…
View article: Community-developed checklists for publishing images and image analyses
Community-developed checklists for publishing images and image analyses Open
View article: Community-developed checklists for publishing images and image analyses.
Community-developed checklists for publishing images and image analyses. Open
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained image…
View article: OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning
OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning Open
Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for their function. For instance, the …
View article: OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning
OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning Open
Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for their function. For instance, the …
View article: Community-developed checklists for publishing images and image analysis
Community-developed checklists for publishing images and image analysis Open
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained image…
View article: Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α Open
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet…
View article: Nanoscale segregation of channel and barrier claudins enables paracellular ion flux
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux Open
View article: LABKIT: Labeling and Segmentation Toolkit for Big Image Data
LABKIT: Labeling and Segmentation Toolkit for Big Image Data Open
We present LABKIT, a user-friendly Fiji plugin for the segmentation of microscopy image data. It offers easy to use manual and automated image segmentation routines that can be rapidly applied to single- and multi-channel images as well as…
View article: Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells Open
The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms co…
View article: SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity
SynActJ: Easy-to-Use Automated Analysis of Synaptic Activity Open
Neuronal synapses are highly dynamic communication hubs that mediate chemical neurotransmission via the exocytic fusion and subsequent endocytic recycling of neurotransmitter-containing synaptic vesicles (SVs). Functional imaging tools all…
View article: Labkit: Labeling and Segmentation Toolkit for Big Image Data
Labkit: Labeling and Segmentation Toolkit for Big Image Data Open
We present L abkit , a user-friendly Fiji plugin for the segmentation of microscopy image data. It offers easy to use manual and automated image segmentation routines that can be rapidly applied to single- and multi-channel images as well …
View article: SynActJ: Easy-to-use automated analysis of synaptic activity
SynActJ: Easy-to-use automated analysis of synaptic activity Open
Neuronal synapses are highly dynamic communication hubs that mediate chemical neurotransmission via the exocytic fusion and subsequent endocytic recycling of neurotransmitter-containing synaptic vesicles (SVs). Functional imaging tools all…
View article: SynActJ: Easy-to-use automated analysis of synaptic activity
SynActJ: Easy-to-use automated analysis of synaptic activity Open
Neuronal synapses are highly dynamic communication hubs that mediate chemical neurotransmission via the exocytic fusion and subsequent endocytic recycling of neurotransmitter-containing synaptic vesicles (SVs). Functional imaging tools all…
View article: SynActJ: Easy-to-use automated analysis of synaptic activity
SynActJ: Easy-to-use automated analysis of synaptic activity Open
Neuronal synapses are highly dynamic communication hubs that mediate chemical neurotransmission via the exocytic fusion and subsequent endocytic recycling of neurotransmitter-containing synaptic vesicles (SVs). Functional imaging tools all…
View article: Effective image visualization for publications – a workflow using open access tools and concepts
Effective image visualization for publications – a workflow using open access tools and concepts Open
Today, 25% of figures in biomedical publications contain images of various types, e.g. photos, light or electron microscopy images, x-rays, or even sketches or drawings. Despite being widely used, published images may be ineffective or ill…
View article: Effective image visualization for publications – a workflow using open access tools and concepts
Effective image visualization for publications – a workflow using open access tools and concepts Open
Today, 25% of figures in biomedical publications contain images of various types, e.g. photos, light or electron microscopy images, x-rays, or even sketches or drawings. Despite being widely used, published images may be ineffective or ill…
View article: Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts
Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts Open
Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real ti…
View article: Selective increases in inter-individual variability in response to environmental enrichment in female mice
Selective increases in inter-individual variability in response to environmental enrichment in female mice Open
One manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in the clinical setting, where subtle differe…
View article: Author response: Selective increases in inter-individual variability in response to environmental enrichment in female mice
Author response: Selective increases in inter-individual variability in response to environmental enrichment in female mice Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract One manifestation of individu…