Christopher Schwake
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View article: Identification of <i>Babesia microti</i> immunoreactive antigens by phage display cDNA screen
Identification of <i>Babesia microti</i> immunoreactive antigens by phage display cDNA screen Open
Human babesiosis is a malaria-like illness caused by protozoan parasites of the genus Babesia . Babesia microti is responsible for most cases of human babesiosis in the United States, particularly in the Northeast and the Upper Midwest. Ba…
View article: Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study Open
[This corrects the article DOI: 10.3389/fnut.2023.1230061.].
View article: <i>Plasmodium falciparum</i> Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes
<i>Plasmodium falciparum</i> Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes Open
Plasmodium falciparum glutamic acid-rich protein (PfGARP) is a recently characterized cell surface antigen encoded by Plasmodium falciparum, the causative agent of severe human malaria pathophysiology. Previously, we reported that the huma…
View article: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study
Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study Open
Introduction The safety of novel forms of iron in healthy, iron-replete adults as might occur if used in population-based iron supplementation programs was examined. We tested the hypotheses that supplementation with nanoparticulate iron h…
View article: <scp>BDA</scp>‐410 inhibits <scp>SARS‐CoV</scp>‐2 main protease activity and viral replication in mammalian cells
<span>BDA</span>‐410 inhibits <span>SARS‐CoV</span>‐2 main protease activity and viral replication in mammalian cells Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel highly virulent coronavirus that causes severe illness and mortality in certain patients. SARS-CoV-2 contains a positive-sense single-stranded RNA genome that encodes …
View article: Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections
Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections Open
Parasitic and viral infections cause severe health and economic burden, exacerbated by the lack of new therapeutics in the pipeline. SPP has been shown to be essential for malaria parasite growth and encouraging evidence in other parasites…
View article: Ferrous Sulfate-Iron (60 mg/d) Does Not Increase Risks to Malarial Infectivity, Pathogenic Bacterial Proliferation or Other Adverse Effects in Non-Anemic Healthy Adults
Ferrous Sulfate-Iron (60 mg/d) Does Not Increase Risks to Malarial Infectivity, Pathogenic Bacterial Proliferation or Other Adverse Effects in Non-Anemic Healthy Adults Open
OBJECTIVES: A double-blind, placebo-controlled, randomized clinical trial was conducted to determine the effects of different modalities of supplementation with ferrous sulfate (FeSO(4))-iron on the safety profiles of non-anemic, healthy a…
View article: Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein
Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid–rich protein Open
Malaria remains a major global threat to human health and economic development. Microvascular lesions caused by Plasmodium falciparum–infected human erythrocytes/red blood cells are hallmarks of severe pathogenesis contributing to high mor…