Simon C. Robson
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View article: <scp>NTPDase8</scp> Protects Against Liver Ischemia–Reperfusion Injury in Mice
<span>NTPDase8</span> Protects Against Liver Ischemia–Reperfusion Injury in Mice Open
CD39 or NTPDase1 and other nucleoside triphosphate diphosphohydrolases (NTPDases), including NTPDase2, NTPDase3, and NTPDase8, regulate purinergic signaling through tuning the extracellular levels of purine nucleotides and nucleosides. Pur…
View article: Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection
Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection Open
Chagas disease, caused by Trypanosoma cruzi, is endemic to Latin America and is characterized by chronic inflammation of cardiac tissues due to parasite persistence. Hypoxia within infected tissues may trigger the stabilization of HIF-1 an…
View article: CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS
CD39 REGULATES P2RX7-MEDIATED LUNG NECROTIC LESIONS IN SEVERE EXPERIMENTAL TUBERCULOSIS Open
SUMMARY Tuberculosis induces diverse lesions, such as necrotic pneumonia, contributing to disease progression and transmission. Despite advances in understanding the role of ATP-gated P2RX7 ion channels in developing severe forms of tuberc…
View article: Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia
Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia Open
Global ischemic brain injury occurs after cardiac arrest or prolonged hypotensive episodes following surgery or trauma. It causes significant neurological deficits even after successful re-establishment of blood flow. It is the primary cau…
View article: Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients
Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients Open
Women undergoing cardiac surgery suffer from worse outcomes than their male counterparts. The reasons for this disparity are multifactorial, but the loss of the protective effects of estrogen likely plays a role. Estrogen acts on the CD39/…
View article: Impact of Estrogen on Purinergic Signaling in Microvascular Disease
Impact of Estrogen on Purinergic Signaling in Microvascular Disease Open
Microvascular ischemia, especially in the heart and kidneys, is associated with inflammation and metabolic perturbation, resulting in cellular dysfunction and end-organ failure. Heightened production of adenosine from extracellular nucleot…
View article: Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility
Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility Open
Lower urinary tract symptoms (LUTS) affect approximately 50% of the population over 40 years of age and are strongly associated with obesity and metabolic syndrome. Adipose tissue plays a key role in obesity/metabolic syndrome by releasing…
View article: Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39 Open
Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain. Here, we show that microglia regulate the cerebral blood flow baseline and the responses to wh…
View article: Purinergic signaling by TCRαβ+ double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury
Purinergic signaling by TCRαβ+ double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury Open
Hepatic ischemia-reperfusion injury (HIRI) is an important cause of liver injury following liver transplantation and major resections, and neutrophils are the key effector cells in HIRI. Double-negative T regulatory cells (DNT) are increas…
View article: Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39
Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39 Open
Microglia and the border-associated macrophages (BAMs) contribute to the modulation of cerebral blood flow (CBF), but the mechanisms have remained ill-defined. Here, we show that microglia regulate the CBF baseline and upsurges after whisk…
View article: Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility
Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility Open
Lower urinary tract symptoms (LUTS) affect ∼ 50% of the population aged >40 years and are strongly associated with obesity and metabolic syndrome. Adipose tissue plays a key role in obesity/metabolic syndrome by releasing adipokines that r…
View article: Cd39 and P2rx7-Wnt signaling enhance blast pathogenicity in an experimental model of acute myeloid leukemia
Cd39 and P2rx7-Wnt signaling enhance blast pathogenicity in an experimental model of acute myeloid leukemia Open
Not available.
View article: CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection
CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection Open
An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 effector res…
View article: Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation
Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation Open
Background Cardiac arrest (CA) is a significant public health concern. There is the high imminent mortality and survival in those who are resuscitated is substantively compromised by the post-CA syndrome (PCAS), characterized by multiorgan…
View article: Role of ecto‐5′‐nucleotidase in bladder function
Role of ecto‐5′‐nucleotidase in bladder function Open
Purinergic signaling plays an important role in regulating bladder contractility and voiding. Abnormal purinergic signaling is associated with lower urinary tract symptoms (LUTS). Ecto‐5′‐nucleotidase (NT5E) catalyzes dephosphorylation of …
View article: Editorial: Advances in immunotherapy and combination therapy for biliary tract cancers
Editorial: Advances in immunotherapy and combination therapy for biliary tract cancers Open
EDITORIAL article Front. Oncol., 08 January 2024Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1360649
View article: Development of endothelial-targeted CD39 as a therapy for ischaemic stroke
Development of endothelial-targeted CD39 as a therapy for ischaemic stroke Open
Background Ischaemic stroke is characterized by a necrotic lesion in the brain surrounded by an area of dying cells termed the penumbra. Salvaging the penumbra either with thrombolysis or mechanical retrieval is the cornerstone of stroke m…
View article: NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow
NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow Open
NTPDase1/CD39, the major vascular ectonucleotidase, exerts thrombo-immunoregulatory function by controlling endothelial P2 receptor activation. Despite the well-described release of ATP from endothelial cells, few data are available regard…
View article: CD39 expression by regulatory T cells drives CD8+ T cell suppression during experimental<i>Trypanosoma cruzi</i>infection
CD39 expression by regulatory T cells drives CD8+ T cell suppression during experimental<i>Trypanosoma cruzi</i>infection Open
An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 effector res…
View article: Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia
Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia Open
Chemoresistance often complicates the management of cancer, as noted in the instance of acute myeloid leukemia (AML). Mitochondrial function is considered important for the viability of AML blasts and appears to also modulate chemoresistan…
View article: Altered purinergic signaling in women undergoing cardiac surgery under cardiopulmonary bypass
Altered purinergic signaling in women undergoing cardiac surgery under cardiopulmonary bypass Open
Despite recent advances in cardiac surgery, adverse outcomes remain more prevalent in females as compared to males. Our study aimed to further understand whether purinergic signaling plays a role in the discrepancy in outcomes of females p…
View article: Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis Open
BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have concomitant atherosclerosis, implying differential pathogenesis. Although circulating extracellular vesicles (EVs) act as biomarkers of cardiovascular disea…
View article: Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals
Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals Open
Although SARS-CoV-2 WGS adds to the total IPC management cost, additional information provided could balance out the additional cost, depending on identified design improvements and effective deployment.
View article: Free heme exacerbates colonic injury induced by anti-cancer therapy
Free heme exacerbates colonic injury induced by anti-cancer therapy Open
Gastrointestinal inflammation and bleeding are commonly induced by cancer radiotherapy and chemotherapy but mechanisms are unclear. We demonstrated an increased number of infiltrating heme oxygenase-1 positive (HO-1+) macrophages (Mø, CD68…
View article: Selective inhibition of estrogen receptor alpha restores regulatory T-cell function in autoimmune hepatitis
Selective inhibition of estrogen receptor alpha restores regulatory T-cell function in autoimmune hepatitis Open
Dysfunction in regulatory T-cells (Tregs) is a hallmark of autoimmune hepatitis (AIH), a serious hepatopathy often leading to end-stage liver damage and transplantation, if not treated. Treg impairment in AIH has been linked to defective r…