Christopher Vidal
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Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo Open
Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescribed osteoporosis drugs have led to the investigation of new and safer treatments with novel mechanisms of act…
The utility of surrogate markers in predicting HLA alleles associated with adverse drug reactions in Vietnamese Open
Screening is recommended for these alleles in Australian Vietnamese prior to introducing relevant therapies. SNPs, rs2395029 and rs9263726, can be successfully used as surrogate markers for HLA-B*57:01 and HLA-B*58:01 in this population.
False-Positive Results of Serological Tests for Allergy in Alcoholic Patients Open
Serological tests for allergy should be interpreted with caution in alcoholic patients, who frequently have increased levels of total IgE and CCD-sIgE and subsequent positivity of sIgE to glycosylated allergen components, irrespective of t…
Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond Open
Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%-50%) and high morbidity (60%) with severe ocular complic…
Developing pharmacogenetic screening methods for an emergent country: Vietnam Open
The optimal approach we propose may serve as a template for the development of screening programs in other emergent countries.
The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation Open
Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro‐osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells…