Christopher L. Wirth
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View article: Coupled Interfacial Phenomena Suppress Propulsion in Catalytic Janus Colloids
Coupled Interfacial Phenomena Suppress Propulsion in Catalytic Janus Colloids Open
Platinum-coated polystyrene Janus particles exhibit a combination of stochastic and deterministic motion in hydrogen peroxide solutions, making them promising candidates for applications in micro-scale cargo transport, drug delivery, and e…
View article: Panorama of Chromosomal Instability in Lung Cancer
Panorama of Chromosomal Instability in Lung Cancer Open
Lung cancer is a highly heterogeneous disease primarily driven by tobacco smoking. About 20% of lung cancers occur among patients who have never smoked (LCINS) with differences in patient ancestry, sex, tumor histology, and clinical featur…
View article: Impact of Surfactant and Flow Rate on the Electrical Properties of Activated Carbon Black Suspensions
Impact of Surfactant and Flow Rate on the Electrical Properties of Activated Carbon Black Suspensions Open
Carbon black slurries are a key component in redox flow batteries as the large surface area provided by the particles allows an increase in the battery capacity without facing limitations posed by many solid-state batteries such as safety …
View article: Causes of evolutionary divergence in prostate cancer.
Causes of evolutionary divergence in prostate cancer. Open
Cancer progression involves the sequential accumulation of genetic alterations that cumulatively shape the tumour phenotype. In prostate cancer, tumours can follow divergent evolutionary trajectories that lead to distinct subtypes, but the…
View article: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition Open
Understanding lung cancer evolution can identify tools for intercepting its growth. In a landscape analysis of 1024 lung adenocarcinomas (LUAD) with deep whole-genome sequencing integrated with multiomic data, we identified 542 LUAD that d…
View article: Direct measurement of surface interactions experienced by sticky microcapsules made from environmentally benign materials
Direct measurement of surface interactions experienced by sticky microcapsules made from environmentally benign materials Open
We present a study combining experimental measurements, theoretical analysis, and simulations to investigate core-shell microcapsules interacting with a solid boundary, with a particular focus on understanding the short-range potential ene…
View article: APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
APOBEC shapes tumor evolution and age at onset of lung cancer in smokers Open
APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retroelements by deaminating cytosine residues 1,2 . Most solid tumors harbor different levels of somatic mutations attributed to the off-target…
View article: Impact of Resin Molecular Weight on Drying Kinetics and Sag of Coatings
Impact of Resin Molecular Weight on Drying Kinetics and Sag of Coatings Open
The work herein investigates the impact of resin molecular weight and solvent choice on drying kinetics and sag velocity in polymer films. These films, ranging in thickness from ~60 micrometer to ~120 micrometer were formulated with 45% by…
View article: Surfactant-Driven Dynamic Changes in Rheology of Activated Carbon Slurry Electrodes
Surfactant-Driven Dynamic Changes in Rheology of Activated Carbon Slurry Electrodes Open
Slurry electrodes are an effective means to improve flow battery performance by reducing electrode fouling and increasing the active surface area necessary for electrochemical reactions. It is critical to understand how the slurry formulat…
View article: An advanced light scattering imaging model for total internal reflection microscopy considering a stratified medium
An advanced light scattering imaging model for total internal reflection microscopy considering a stratified medium Open
An advanced light scattering model for Total Internal Reflection Microscopy (TIRM) is presented. The model considers the specific TIRM geometry and deals with the scattering by an axisymmetric particle of arbitrary orientation placed in a …
View article: Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Patient-derived xenograft (PDX) and circulating tumor cell–derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of …
View article: Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Overview of data processing pipeline.
View article: Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Mapping percentages for RNA-sequencing datasets.
View article: Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Differences in fold change between primary tumour and CDXF1 before and after processing using Xenome.
View article: Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Mapping percentages for RNA-sequencing datasets.
View article: Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Patient-derived xenograft (PDX) and circulating tumor cell–derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of …
View article: Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Overview of data processing pipeline.
View article: Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Differences in fold change between primary tumour and CDXF1 before and after processing using Xenome.
View article: Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Variant Allele Frequencies for the CDXF1 model.
View article: Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Variant Allele Frequencies for the CDXF1 model.
View article: Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin
Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin Open
Could the phenomenon of catch bonding—force-strengthened cellular adhesion—play a role in sickle cell disease, where abnormal red blood cell (RBC) adhesion obstructs blood flow? Here we investigate the dynamics of sickle RBCs adhering to a…
View article: Surfactant Induced Catastrophic Collapse of Carbon Black Suspension used in Flow Battery Application
Surfactant Induced Catastrophic Collapse of Carbon Black Suspension used in Flow Battery Application Open
Carbon black particles act as electronically conductive additives in the slurry electrodes used in electrochemical redox flow batteries. Stability and dispersion of the carbon black particles in a slurry electrode are critical parameters f…
View article: Anisotropic colloidal particles near boundaries
Anisotropic colloidal particles near boundaries Open
Anisotropic colloidal particles are regularly found in applications ranging from health to energy. These particles, typically with non-uniform shape or surface chemistry, interact with boundaries in unique ways, offering pathways to comple…
View article: Influence of cap weight on the motion of a Janus particle very near a wall
Influence of cap weight on the motion of a Janus particle very near a wall Open
The dynamics of anisotropic nano- to micro scale colloidal particles in confined environments, either near neighboring particles or boundaries, is relevant to a wide range of applications. We utilized Brownian dynamics simulations to predi…