Christopher Zalewski
YOU?
Author Swipe
View article: Correction: TILLCANN: a TILLING platform in Cannabis sativa for mutation discovery and crop improvement
Correction: TILLCANN: a TILLING platform in Cannabis sativa for mutation discovery and crop improvement Open
View article: TILLCANN: a TILLING platform in Cannabis sativa for mutation discovery and crop improvement
TILLCANN: a TILLING platform in Cannabis sativa for mutation discovery and crop improvement Open
View article: Systematic phenotype and genotype characterization of Moebius syndrome
Systematic phenotype and genotype characterization of Moebius syndrome Open
We did not identify a strong or unifying germline genetic etiology for MBS. Future studies may explore alternative causes, including environmental exposures, somatic variants, and/or complex inheritance patterns affecting brainstem and org…
View article: TILLCANN: A TILLING platform in<i>Cannabis sativa</i>for mutation discovery and crop improvement
TILLCANN: A TILLING platform in<i>Cannabis sativa</i>for mutation discovery and crop improvement Open
Cultivation of Cannabis sativa is increasing because of its therapeutic value and recognition as a multi-purpose and sustainable crop. Targeting Induced Local Lesions in Genomes (TILLING) is a versatile reverse genetics approach that unloc…
View article: A new paradigm for assessing postural stability
A new paradigm for assessing postural stability Open
View article: Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI)
Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI) Open
View article: Characterization of Hearing-Impairment in Generalized Arterial Calcification of Infancy (GACI)
Characterization of Hearing-Impairment in Generalized Arterial Calcification of Infancy (GACI) Open
Background and Importance Hearing loss (HL) has been sporadically described, but not well characterized, in Generalized Arterial Calcification of Infancy (GACI), a rare disease in which pathological calcification typically presents in infa…
View article: Hearing Loss and Irritability Reporting Without Vestibular Differences in Explosive Breaching Professionals
Hearing Loss and Irritability Reporting Without Vestibular Differences in Explosive Breaching Professionals Open
Background: Blast exposure is a potential hazard in modern military operations and training, especially for some military occupations. Helmets, peripheral armor, hearing protection, and eye protection worn by military personnel provide som…
View article: Author response for "Vestibular <scp>Phenotype‐Genotype</scp> Correlation in a Cohort of 90 Patients with Usher Syndrome"
Author response for "Vestibular <span>Phenotype‐Genotype</span> Correlation in a Cohort of 90 Patients with Usher Syndrome" Open
View article: The peroxisomal disorder spectrum and Heimler syndrome: Deep phenotyping and review of the literature
The peroxisomal disorder spectrum and Heimler syndrome: Deep phenotyping and review of the literature Open
The spectrum of peroxisomal disorders is wide and comprises individuals that die in the first year of life, as well as people with sensorineural hearing loss, retinal dystrophy and amelogenesis imperfecta. In this article, we describe thre…
View article: Atypical and ultra-rare Usher syndrome: a review
Atypical and ultra-rare Usher syndrome: a review Open
Usher syndrome has classically been described as a combination of hearing loss and rod-cone dystrophy; vestibular dysfunction is present in many patients. Three distinct clinical subtypes were documented in the late 1970s. Genotyping effor…
View article: Association of Hearing Loss and Otologic Outcomes With Fibrous Dysplasia
Association of Hearing Loss and Otologic Outcomes With Fibrous Dysplasia Open
Hearing loss in craniofacial FD is common and mild to moderate in most individuals. It typically arises from FD crowding of the ossicular chain and elongation of the IAC, whereas EAC stenosis and otic capsule invasion are less common cause…
View article: A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome
A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome Open
Multinucleate cellular syncytial formation is a hallmark of skeletal muscle differentiation. Myomaker, encoded by Mymk (Tmem8c) , is a well-conserved plasma membrane protein required for myoblast fusion to form multinucleated myotubes in m…
View article: Hearing Safety From Single- and Double-Pulse Transcranial Magnetic Stimulation in Children and Young Adults
Hearing Safety From Single- and Double-Pulse Transcranial Magnetic Stimulation in Children and Young Adults Open
Purpose: Concerns regarding hearing safety have limited the number of studies using transcranial magnetic stimulation (TMS) in children and young adults. The objective of this study was to examine the safety of TMS with regards to hearing …
View article: Auditory Phenotype of Smith–Magenis Syndrome
Auditory Phenotype of Smith–Magenis Syndrome Open
Purpose The purpose of this study was to describe the auditory phenotype of a large cohort with Smith–Magenis syndrome (SMS), a rare disorder including physical anomalies, cognitive deficits, sleep disturbances, and a distinct behavioral p…
View article: Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2–Associated Vestibular Schwannomas
Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2–Associated Vestibular Schwannomas Open
Purpose Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized by bilateral vestibular schwannomas (VSs) resulting in deafness and brainstem compression. This study evaluated efficacy and biomarkers of bevacizumab …
View article: Heritability of non-speech auditory processing skills
Heritability of non-speech auditory processing skills Open
View article: Cystic cerebellar dysplasia and biallelic <i>LAMA1</i> mutations: a lamininopathy associated with tics, obsessive compulsive traits and myopia due to cell adhesion and migration defects
Cystic cerebellar dysplasia and biallelic <i>LAMA1</i> mutations: a lamininopathy associated with tics, obsessive compulsive traits and myopia due to cell adhesion and migration defects Open
Background Laminins are heterotrimeric complexes, consisting of α, β and γ subunits that form a major component of basement membranes and extracellular matrix. Laminin complexes have different, but often overlapping, distributions and func…
View article: Atypical patterns of segregation of familial enlargement of the vestibular aqueduct
Atypical patterns of segregation of familial enlargement of the vestibular aqueduct Open
NA Laryngoscope, 126:E240-E247, 2016.
View article: Aging of the Human Vestibular System
Aging of the Human Vestibular System Open
Aging affects every sensory system in the body, including the vestibular system. Although its impact is often difficult to quantify, the deleterious impact of aging on the vestibular system is serious both medically and economically. The d…
View article: Phase 1 trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors
Phase 1 trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors Open
The MTD of oral satraplatin in children with solid tumors was 60 mg/m(2) /dose daily ×5 days every 28 days, which is lower than the adult recommended dose of 80-120 mg/m(2) /dose. The toxicity profile was similar to adults and delayed myel…