Explanipedia

Characterization of Porcine Ventral Mesencephalic Precursor Cells following Long-Term Propagation in 3D Culture Open

Pia S. Jensen, Lise Lyck, Pia Jensen, Jens Zimmer, Morten Meyer · 2012

The potential use of predifferentiated neural precursor cells for treatment of a neurological disorder like Parkinson’s disease combines stem cell research with previous experimental and clinical transplantation of developing dopaminergic …

Population Control of Resident and Immigrant Microglia by Mitosis and Apoptosis Open

Martin Wirenfeldt, Lasse Dissing‐Olesen, Alicia A. Babcock, Marianne Nielsen, Michael Meldgaard , et al. · 2007

Toxic Effects of Lipid‐Mediated Gene Transfer in Ventral Mesencephalic Explant Cultures Open

Matthias Bauer, Bjarne Winther Kristensen, Morten Meyer, Thomas Gasser, Hans R. Widmer , et al. · 2006

Adverse effects of cDNA and oligonucleotide delivery methods have not yet been systematically analyzed. We introduce a protocol to monitor toxic effects of two non‐viral lipid‐based gene delivery protocols using CNS primary tissue. Cell me…

Neural transdifferentiation of mesenchymal stem cells – a critical review Open

Christina Krabbe, Jens Zimmer, Morten Meyer · 2005

The classic concept of stem cell differentiation can be illustrated as driving into a series of one‐way streets, where a given stem cell through generations of daughter cells becomes correspondingly restricted and committed towards a defin…

Modulator Effects of Interleukin-1β and Tumor Necrosis Factor-α on AMPA-Induced Excitotoxicity in Mouse Organotypic Hippocampal Slice Cultures Open

Liliana Bernardino, Sara Xapelli, Ana Paula Silva, Birthe Jakobsen, Frantz Rom Poulsen , et al. · 2005

The inflammatory cytokines interleukin-1β and tumor necrosis factor-α (TNF-α) have been identified as mediators of several forms of neurodegeneration in the brain. However, they can produce either deleterious or beneficial effects on neuro…

Transplantation of Embryonic Porcine Neocortical Tissue into Newborn Rats Open

Anthony J. Castro, Morten Meyer, Annette Møller-Dall, Jens Zimmer · 2003

Several previous studies, suggesting the potential use of embryonic xenografts in the treatment of neurological disorders, indicate that neural growth and axonal guidance factors may function across species. In this light, blocks of fetal …

Quantitative [<sup>18</sup>F]Fluorodopa/PET and Histology of Fetal Mesencephalic Dopaminergic Grafts to the Striatum of MPTP-Poisoned Minipigs Open

Annette Møller Dall, Erik Hvid Danielsen, Jens Christian Hedemann Sørensen, Flemming Littrup Andersen, Arne Møller , et al. · 2002

The functional restoration of the dopamine innervation of striatum in MPTP-poisoned Göttingen minipigs was assessed for 6 months following grafting of fetal pig mesencephalic neurons. Pigs were assigned to a normal control group and a MPTP…

Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures Open

Bjarne Winther Kristensen, Jens Noraberg, Pierre Thiébaud, M. Koudelka‐Hep, Jens Zimmer · 2001

Neural Xenotransplantation: Pretreatment of Porcine Embryonic Nigral Tissue with Anti-Gal Antibodies and Complement is not Toxic for the Dopaminergic Neurons Open

Thomas Brevig, Morten Meyer, Tom Kristensen, Jens Zimmer · 2001

The immunogenicity of porcine tissue is a major obstacle to its use as donor material in xenotransplantation for neurodegenerative diseases. We are currently evaluating a novel strategy for reducing the immunogenicity, in which the α-galac…

The DaNeX Study of Embryonic Mesencephalic, Dopaminergic Tissue Grafted to a Minipig Model of Parkinson's Disease: Preliminary Findings of Effect of MPTP Poisoning on Striatal Dopaminergic Markers Open

Erik Hvid Danielsen, P. Dimming, Flemming Littrup Andersen, Dirk Bender, Thomas Brevig , et al. · 2000

A multicenter study is under way to investigate the efficacy of allografting of embryonic mesencephalic neurons in a pig model of Parkinson's disease. We have first established that a stable parkinsonian syndrome can be established by 1-me…

Neural Tissue Xenotransplantation: What is Needed Prior to Clinical Trials in Parkinson's Disease? Open

Roger A. Barker, A. L. Kendall, Håkan Widner, Håkan Widner, Lena C. Larsson , et al. · 2000

Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical…

Three-dimensional microelectrodes arrays (MEAs) for in-vitro brain slices recording ans stimulation Open

Luca Berdondini, Pierre Thiébaud, Ν. F. de Rooij, M. Koudelka‐Hep, Rüdiger Köhling , et al. · 2000

Coupling of Organotypic Brain Slice Cultures to Silicon-Based Arrays of Electrodes Open

Henrik Jahnsen, Bjarne Winther Kristensen, Pierre Thiébaud, Jens Noraberg, Birthe Jakobsen , et al. · 1999

An array of Pt-tip microelectrodes for extracellular monitoring of activity of brain slices1This paper was presented at the Fifth World Congress on Biosensors, Berlin, Germany, 3–5 June 1998.1 Open

Pierre Thiébaud, C. Beuret, M. Koudelka‐Hep, Marco Bove, Sérgio Martinoia , et al. · 1999

GDNF Increases the Density of Cells Containing Calbindin but Not of Cells Containing Calretinin in Cultured Rat and Human Fetal Nigral Tissue Open

Morten Meyer, Jens Zimmer, Rolf W. Seiler, Hans R. Widmer · 1999

Among the dopaminergic neurons in substantia nigra pars compacta and in the ventral tegmental area, subpopulations express the calcium-binding proteins calbindin (CB) and calretinin (CR), and the CB-containing neurons are supposed to be le…

Meetings and Notices Open

Ecrr, Mr Kirsten, Jens Zimmer, Thomas Kossmann, Stephen Sofer · 1998

Proliferative Response of Human T Lymphocytes to Porcine Fetal Brain Cells Open

Thomas Brevig, E Pedersen, Tom Kristensen, Jens Zimmer · 1997

Intracerebral grafting of porcine fetal brain cells is a potential treatment of neurodegenerative disorders in humans. Although it is well known that the survival of fetal pig brain cells in the rat brain requires immunosuppression, the re…

Fetal Neocortical Transplants Grafted into Neocortical Lesion Cavities Made in Newborn Rats: An Analysis of Transplant Integration with the Host Brain Open

Mette Katrine Schulz, John A. McNulty, Robert J. Handa, Thomas P. Hogan, G.L. Tillotson , et al. · 1995

Fetal neocortical transplants placed into frontal cortex aspiration lesion cavities in newborn rats have been shown to survive and exchange connections with the host brain. To further study the afferent innervation of such transplants, enz…

A double staining technique for simultaneous demonstration of astrocytes and microglia in brain sections and astroglial cell cultures. Open

Bernardo Castellano, Berta González, M.B. Jensen, E Pedersen, Bente Finsen , et al. · 1991

We developed a double staining technique for simultaneous demonstration of astrocytes and microglial cells in histological brain sections and cell cultures. The procedure included a histochemical stain specific for microglial cells and an …

Preface Open

Torben Lykke Sørensen, Jens Zimmer · 1991

Histochemical demonstration of purine nucleoside phosphorylase (PNPase) in microglial and astroglial cells of adult rat brain. Open

Bernardo Castellano, Berta González, Bente Finsen, Jens Zimmer · 1990

The histochemical localization of enzymes associated with purine nucleoside metabolism indicates that glial cells might participate in the regulation of these compounds in the central nervous system. In the present study we examined the hi…

Deficits in Beam‐Walking After Neonatal Motor Cortical Lesions are not Spared by Fetal Cortical Transplants in Rats Open

Rand S. Swenson, Erik Hvid Danielsen, B. S. Klausen, E. Erlich, Jens Zimmer , et al. · 1989

Adult rats that sustained unilateral motor cortical lesions at birth demonstrated deficits in traversing an elevated narrow beam. These deficits, manifested by hindlimb slips off the edge of the beam, were not spared in animals that receiv…

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