Christos Chatzakis
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View article: PARP Inhibitor Maintenance After First-Line Chemotherapy in Advanced-Stage Epithelial Ovarian Cancer
PARP Inhibitor Maintenance After First-Line Chemotherapy in Advanced-Stage Epithelial Ovarian Cancer Open
Importance First-line maintenance therapy with poly(adenosine diphosphate-ribose) polymerase inhibitors (PARP inhibitors) after platinum-based chemotherapy improves progression-free survival (PFS) in advanced epithelial ovarian cancer (EOC…
View article: The Impact of Ursodeoxycholic Acid on Fetal Cardiac Function in Women with Gestational Diabetes Mellitus: A Randomized Controlled Study (GUARDS Trial)
The Impact of Ursodeoxycholic Acid on Fetal Cardiac Function in Women with Gestational Diabetes Mellitus: A Randomized Controlled Study (GUARDS Trial) Open
Background: Gestational diabetes mellitus (GDM) is associated with subclinical alterations in fetal cardiac morphology and function. Ursodeoxycholic acid (UDCA), widely used in pregnancy for intrahepatic cholestasis, has demonstrated cardi…
View article: The Impact of Ursodeoxycholic Acid on Fetal Cardiac Function in Women with Gestational Diabetes Mellitus: A Randomized Controlled Study (GUARDS Trial)
The Impact of Ursodeoxycholic Acid on Fetal Cardiac Function in Women with Gestational Diabetes Mellitus: A Randomized Controlled Study (GUARDS Trial) Open
Background: Gestational diabetes mellitus (GDM) is associated with subclinical alterations in fetal cardiac morphology and function. Ursodeoxycholic acid (UDCA), widely used in pregnancy for intrahepatic cholestasis, has demonstrated cardi…
View article: Carbohydrate and lipid metabolism in neonates and children born SGA. A systematic review and metanalysis
Carbohydrate and lipid metabolism in neonates and children born SGA. A systematic review and metanalysis Open
View article: Unmasking the Placenta–Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease
Unmasking the Placenta–Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease Open
Congenital heart disease (CHD), the most prevalent congenital abnormality, is becoming increasingly acknowledged as a component of a broad fetoplacental pathology. This systematic review summarizes recent imaging-based data linking CHD to …
View article: A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions
A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions Open
Gestational diabetes mellitus (GDM) is a frequently encountered medical complication during pregnancy that is increasing at a rapid pace globally, posing significant public health concerns. Similarly, there is a rising trend in the number …
View article: Cytomegalovirus universal screening in early pregnancy: truth is a tendency
Cytomegalovirus universal screening in early pregnancy: truth is a tendency Open
View article: Vascular Assessment Stratifying Preeclampsia Risk in Overweight/Obese Women
Vascular Assessment Stratifying Preeclampsia Risk in Overweight/Obese Women Open
BACKGROUND: Overweight and obesity greatly increase the risk of preeclampsia. There is a need to better risk-stratify these women in pregnancy and channel resources to those who can benefit most. METHODS: Prospective observational study of…
View article: A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in ART Pregnancies: Current Trends and Future Directions
A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in ART Pregnancies: Current Trends and Future Directions Open
View article: Inherited thrombophilias and stillbirth: a systematic review and meta- analysis
Inherited thrombophilias and stillbirth: a systematic review and meta- analysis Open
Purpose The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G2…
View article: Incremental yield of exome sequencing over standard prenatal testing in structurally normal fetuses: systematic review and meta‐analysis
Incremental yield of exome sequencing over standard prenatal testing in structurally normal fetuses: systematic review and meta‐analysis Open
Objective To critically review the literature and synthesize evidence on the incremental yield of prenatal exome sequencing (PES) in fetuses with an apparently normal phenotype with a normal G‐banded karyotype or chromosomal microarray (CM…
View article: A Review of the Impact of Gestational Diabetes on Fetal Brain Development: An Update on Neurosonographic Markers During the Last Decade
A Review of the Impact of Gestational Diabetes on Fetal Brain Development: An Update on Neurosonographic Markers During the Last Decade Open
Gestational diabetes mellitus (GDM) is a prevalent medical complication in pregnancy that is rapidly escalating worldwide, with epidemic implications. This systematic review aims to identify fetal brain changes using neurosonography and pi…
View article: Metformin for Treating Gestational Diabetes: What Have We Learned During the Last Two Decades? A Systematic Review
Metformin for Treating Gestational Diabetes: What Have We Learned During the Last Two Decades? A Systematic Review Open
There has been accumulating evidence over the past two decades that metformin can be an effective treatment for gestational diabetes mellitus (GDM) in women whose diet and exercise fail to attain optimal glycemic control. The objective of …
View article: Physical activity (PA) during pregnancy in Greece
Physical activity (PA) during pregnancy in Greece Open
The Greek version of the PPAQ is a reliable tool for assessing PA in pregnant Greek women. Higher educational levels and advanced gestational age were found to be associated with increased PA levels. However, only a small proportion of pre…
View article: Association of maternal body mass index with hemodynamic and vascular alterations at 35–37 weeks' gestation
Association of maternal body mass index with hemodynamic and vascular alterations at 35–37 weeks' gestation Open
Objective Globally, one in four pregnant women is classified as overweight or obese, based on their prepregnancy body mass index (BMI). Obese pregnant women are at increased risk of adverse pregnancy outcomes and long‐term cardiovascular d…
View article: Cannabis Use during Pregnancy: An Update
Cannabis Use during Pregnancy: An Update Open
The use of cannabis during pregnancy has emerged as a mounting cause for concern due to its potential adverse consequences on both the mother and her offspring. This review will focus on the dangers associated with prenatal exposure to can…
View article: Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review
Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review Open
The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading to heightened mortality and morbidity rates. Vaccination has emerged as a pivotal strategy in reducing COVID-19-related deaths and ill…
View article: Does exogenous glucocorticoid administration during pregnancy precipitate the timing of labor? A scoping review
Does exogenous glucocorticoid administration during pregnancy precipitate the timing of labor? A scoping review Open
Introduction: To investigate whether synthetic (s) glucocorticoids (GCs) administrated between 24th and 34th gestational weeks in pre-term labor, might precipitate labor, studies upon sGCs administration were reviewed. Physiology of endoge…
View article: Corrigendum to “Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)” [The Lancet Regional Health – Europe 40 (2024) 100892]
Corrigendum to “Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)” [The Lancet Regional Health – Europe 40 (2024) 100892] Open
View article: Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)
Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI) Open
View article: The Effect of Maternal Diet and Physical Activity on the Epigenome of the Offspring
The Effect of Maternal Diet and Physical Activity on the Epigenome of the Offspring Open
The aim of this review was to examine the current literature regarding the effect of maternal lifestyle interventions (i.e., diet and physical activity) on the epigenome of the offspring. PubMed, Scopus and Cochrane-CENTRAL were screened u…
View article: Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis
Effect of Intraperitoneal Chemotherapy with Regorafenib on IL-6 and TNF-α Levels and Peritoneal Cytology: Experimental Study in Rats with Colorectal Peritoneal Carcinomatosis Open
Cytoreductive surgery (CRS), combined with hyperthermic intraperitoneal chemotherapy, has significantly improved survival outcomes in patients with peritoneal carcinomatosis from colorectal cancer (CRC). Regorafenib is an oral agent admini…
View article: Uterine Arteries Resistance in Pregnant Women with Gestational Diabetes Mellitus, Diabetes Mellitus Type 1, Diabetes Mellitus Type 2, and Uncomplicated Pregnancies
Uterine Arteries Resistance in Pregnant Women with Gestational Diabetes Mellitus, Diabetes Mellitus Type 1, Diabetes Mellitus Type 2, and Uncomplicated Pregnancies Open
Background: The examination of the uterine arteries using Doppler in the first trimester of pregnancy serves as a valuable tool for evaluating the uteroplacental circulation. Diabetes mellitus is associated with altered placental implantat…
View article: The Impact of a Single Supervised Exercise Session in the Third Trimester of Pregnancy on the Physical Activity Levels of Pregnant Women—A Pilot Study
The Impact of a Single Supervised Exercise Session in the Third Trimester of Pregnancy on the Physical Activity Levels of Pregnant Women—A Pilot Study Open
Background: Despite the numerous beneficial effects of physical exercise during pregnancy, the levels of physical activity remain low. The aim of the study is to investigate the impact of a single supervised physical exercise session on th…
View article: OC05.02: Metabolic profile of children and neonates born small for gestational age: a systematic review and meta‐analysis
OC05.02: Metabolic profile of children and neonates born small for gestational age: a systematic review and meta‐analysis Open
The fetal origins of adult disease hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development and increases the risk of specific diseases in later life. Aim of this meta-analysis is to ass…
View article: OP05.07: Spital arteries remodelling in consecutive pregnancies
OP05.07: Spital arteries remodelling in consecutive pregnancies Open
This study aims to evaluate the hypothesis that the spiral arteries remodelling persists to some extent in consecutive pregnancies. Data from pregnant women in the first trimester scan of the first and second pregnancy were obtained. The p…
View article: The Efficacy of Probiotics, Prebiotics, and Synbiotics in Patients Who Have Undergone Abdominal Operation, in Terms of Bowel Function Post-Operatively: A Network Meta-Analysis
The Efficacy of Probiotics, Prebiotics, and Synbiotics in Patients Who Have Undergone Abdominal Operation, in Terms of Bowel Function Post-Operatively: A Network Meta-Analysis Open
Background: Abdominal operations may lead to post-operative bowel dysfunction, while administration of probiotics, prebiotics and synbiotics may limit its manifestation. Τhe study aimed to assess the efficacy of probiotics, prebiotics and …
View article: Effect of mode of delivery on perinatal outcome in severe preterm birth: systematic review and meta‐analysis
Effect of mode of delivery on perinatal outcome in severe preterm birth: systematic review and meta‐analysis Open
Objective To review the evidence on the effect of mode of delivery on perinatal outcome of fetuses born before 32 weeks' gestation. Methods MEDLINE, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), the ClinicalTrials.gov r…
View article: Supplementary Material for: The effect of resolution level and targeted design in the diagnostic performance of prenatal chromosomal microarray analysis
Supplementary Material for: The effect of resolution level and targeted design in the diagnostic performance of prenatal chromosomal microarray analysis Open
Introduction This study was performed to assess the optimal resolution for prenatal testing by array comparative genomic hybridization (aCGH), aiming to balance between maximum diagnostic yield and minimal detection of variants of unknown …
View article: The Effect of Valacyclovir on Secondary Prevention of Congenital Cytomegalovirus Infection, Following Primary Maternal Infection Acquired Periconceptionally or in the First Trimester of Pregnancy. An Individual Patient Data Meta-Analysis
The Effect of Valacyclovir on Secondary Prevention of Congenital Cytomegalovirus Infection, Following Primary Maternal Infection Acquired Periconceptionally or in the First Trimester of Pregnancy. An Individual Patient Data Meta-Analysis Open