Christos Davatzikos
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View article: IMG-33. Unveiling glioblastoma heterogeneity with deep learning derived MRI subtyping: insights from the global ReSPOND consortium
IMG-33. Unveiling glioblastoma heterogeneity with deep learning derived MRI subtyping: insights from the global ReSPOND consortium Open
PURPOSE This study aims to identify distinct imaging subtypes of glioblastoma using multi-modal MRIs from the ReSPOND consortium, providing insights into tumor heterogeneity to inform personalized treatment approaches. METHODS We analyzed …
View article: The predictive power of brain-predicted age and leg strength on mobility decline in aging: findings from the Baltimore Longitudinal Study of Aging
The predictive power of brain-predicted age and leg strength on mobility decline in aging: findings from the Baltimore Longitudinal Study of Aging Open
Muscle weakness and poor brain health both contribute to mobility limitations in older adults, but their respective contributions and interactions are not well understood. This study examines the relationship between magnetic resonance ima…
View article: Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study
Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study Open
Predicting the likelihood of developing Alzheimer’s disease (AD) dementia in at-risk individuals is important for the design of and optimal recruitment for clinical trials of disease-modifying therapies. Machine learning (ML) has been show…
View article: MRI-based multi-organ clocks for healthy aging and disease assessment
MRI-based multi-organ clocks for healthy aging and disease assessment Open
Biological aging clocks across organ systems and tissues have advanced understanding of human aging and disease. In this study, we expand this framework to develop seven magnetic resonance imaging-based multi-organ biological age gaps (MRI…
View article: Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling
Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling Open
Brain-wide association studies using functional MRI have advanced our understanding of how behavioral traits relate to individual variability in brain function. These studies typically identify functional connectivity (FC) patterns linked …
View article: CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals
CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals Open
Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier…
View article: Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics Open
Multi-organ research investigates interconnections among multiple human organ systems, enhancing our understanding of human aging and disease mechanisms. Here we use multi-organ imaging, individual- and summary-level genetics, and proteomi…
View article: The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond
The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond Open
The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT‐AD) is an investigator‐driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic …
View article: Agentic Large-Language-Model Systems in Medicine: A Systematic Review and Taxonomy
Agentic Large-Language-Model Systems in Medicine: A Systematic Review and Taxonomy Open
View article: Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study
Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study Open
INTRODUCTION This study investigates the impact of cardiometabolic conditions, including type 2 diabetes, hyperlipidemia, hypertension, and obesity, on the progression of mild cognitive impairment (MCI) to dementia. METHODS The cohort incl…
View article: Multi-organ AI Endophenotypes Chart the Heterogeneity of Pan-disease in the Brain, Eye, and Heart
Multi-organ AI Endophenotypes Chart the Heterogeneity of Pan-disease in the Brain, Eye, and Heart Open
Disease heterogeneity and commonality pose significant challenges to precision medicine, as traditional approaches frequently focus on single disease entities and overlook shared mechanisms across conditions 1 . Inspired by pan-cancer 2 an…
View article: Sleep chart of biological aging clocks across organs and omics
Sleep chart of biological aging clocks across organs and omics Open
Optimal sleep plays a vital role in promoting healthy aging and enhancing longevity. This study proposes a Sleep Chart to assess the relationship between sleep duration and 23 biological aging clocks across 17 organ systems or tissues and …
View article: Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state
Brain texture alterations predict subtle visual perceptual dysfunctions in recent onset psychosis and clinical high-risk state Open
Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture features, could advance our understanding of the underl…
View article: The PREVENT-AD cohort: accelerating Alzheimer’s disease research and treatment in Canada and beyond
The PREVENT-AD cohort: accelerating Alzheimer’s disease research and treatment in Canada and beyond Open
The PREVENT-AD is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than…
View article: AI-Powered Segmentation and Prognosis with Missing MRI in Pediatric Brain Tumors
AI-Powered Segmentation and Prognosis with Missing MRI in Pediatric Brain Tumors Open
Importance Brain MRI is the main imaging modality for pediatric brain tumors (PBTs); however, incomplete MRI exams are common in pediatric neuro-oncology settings and pose a barrier to the development and application of deep learning (DL) …
View article: Multi-organ MRI digitizes biological aging clocks across proteomics, metabolomics, and genetics
Multi-organ MRI digitizes biological aging clocks across proteomics, metabolomics, and genetics Open
Leveraging clinical phenotypes 1,2 , neuroimaging 3 , proteomics 4 , metabolomics 5 , and epigenetics 6 , biological aging clocks across organ systems and tissues have advanced our understanding of human aging and disease. In this study, w…
View article: A Pan-Organ Vision-Language Model for Generalizable 3D CT Representations
A Pan-Organ Vision-Language Model for Generalizable 3D CT Representations Open
Generalizable foundation models for computed tomographic (CT) medical imaging data are emerging AI tools anticipated to vastly improve clinical workflow efficiency. However, existing models are typically trained within narrow imaging conte…
View article: Precision Neuromodulation with Real-Time Brain Decoding for Working Memory Enhancement
Precision Neuromodulation with Real-Time Brain Decoding for Working Memory Enhancement Open
SUMMARY Transcranial magnetic stimulation (TMS) has transformed non-invasive brain therapies but faces challenges due to variability in outcomes, likely stemming from inter-individual differences in brain function. This study aimed to addr…
View article: BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023
BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023 Open
Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-i…
View article: Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations
Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations Open
Dementia, a degenerative disease affecting millions globally, is projected to triple by 2050. Early and precise diagnosis is essential for effective treatment and improved quality of life. However, current diagnostic approaches frequently …
View article: White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease Open
Importance There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD). Objective To investigate the associations between…
View article: Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis
Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi‐Ethnic Study of Atherosclerosis Open
INTRODUCTION We aimed to examine the global impact of brain small vessel disease (SVD) on cognitive performance. METHODS In 892 participants from the Multi‐Ethnic Study of Atherosclerosis (MESA), we derived perivascular spaces (PVS), white…
View article: Reproducible sex differences in personalised functional network topography in youth
Reproducible sex differences in personalised functional network topography in youth Open
Background A key step toward understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organisation at the critical transition from childhood to a…
View article: Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration Open
Mechanisms underlying the dynamic relationships of viral infections and neurodegeneration warrant examination. Using a community-based cohort of older adults, the current study characterized the neurocognitive (cognitive functioning, brain…
View article: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy Open
View article: Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk
Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk Open
Multi-organ biological aging clocks across different organ systems have been shown to predict human disease and mortality. Here, we extend this multi-organ framework to plasma metabolomics, developing five organ-specific metabolome-based b…
View article: Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease Open
Background Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer’s disease (AD), yet their underlying biological mechanisms remain unclear. This study aims to identify the genetic architecture of limbic WM microstruct…
View article: Neurophysiological correlates of neuroanatomical dimensions in major depressive disorder: EEG markers of brain function and treatment outcome
Neurophysiological correlates of neuroanatomical dimensions in major depressive disorder: EEG markers of brain function and treatment outcome Open
Major depressive disorder (MDD) is a heterogeneous disorder with variable treatment responses and no established biomarkers for identification or predictors of treatment response. In the COORDINATE-MDD consortium, a data-driven classificat…
View article: <scp>MRI</scp> Distance Measures as a Predictor of Subsequent Clinical Status During the Preclinical Phase of Alzheimer's Disease and Related Disorders
<span>MRI</span> Distance Measures as a Predictor of Subsequent Clinical Status During the Preclinical Phase of Alzheimer's Disease and Related Disorders Open
Brain atrophy over time, as measured by magnetic resonance imaging (MRI), has been shown to predict subsequent cognitive impairment among individuals who were cognitively normal when first evaluated, indicating that subtle brain atrophy as…
View article: A genetically informed brain atlas for enhancing brain imaging genomics
A genetically informed brain atlas for enhancing brain imaging genomics Open