Christy A. Warby
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View article: Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort
Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort Open
These results establish obesity-associated adipose tissue dysregulation as a key intertissue modulator of biology, with concordant cross-species effects on tumor cell-intrinsic inflammatory and metabolic programs.
View article: Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study
Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study Open
Background Cachexia accounts for about 20% of all cancer-related deaths and it is indicative of poor prognosis and progressive functional impairment. The role of the gut microbiome in the development of cachexia in colorectal cancer (CRC) …
View article: Associations of Biomarkers of Systemic Inflammation, Angiogenesis, and Cell‐to‐Cell Adhesion With Tumor Budding Among Early‐Onset and Later‐Onset Colorectal Cancer Patients
Associations of Biomarkers of Systemic Inflammation, Angiogenesis, and Cell‐to‐Cell Adhesion With Tumor Budding Among Early‐Onset and Later‐Onset Colorectal Cancer Patients Open
Background High tumor budding and elevated systemic inflammation are adverse prognostic indicators in colorectal cancer. Its underlying mechanisms remain poorly understood. It is unclear whether systemic inflammation, angiogenesis, and cel…
View article: Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors
Obesity promotes conserved inflammatory and metabolic transcriptional programs in mouse and human colon tumors Open
Background: The global prevalence of obesity, an established risk and progression factor for colon cancer, is high and rising. Unfortunately, the mechanisms underlying the obesity-colon cancer association are incompletely understood, and n…
View article: <scp><i>Fusobacterium nucleatum</i></scp> Abundance is Associated with Cachexia in Colorectal Cancer Patients: The <scp>ColoCare</scp> Study
<span><i>Fusobacterium nucleatum</i></span> Abundance is Associated with Cachexia in Colorectal Cancer Patients: The <span>ColoCare</span> Study Open
Background Cachexia accounts for about 20% of all cancer‐related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn ), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC h…
View article: Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer
Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer Open
Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we …
View article: Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients Open
Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
View article: Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients Open
Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
View article: Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients Open
Background:Physical activity and obesity are well-established factors of colorectal cancer risk and prognosis. Here, we investigate associations of individual and combined physical activity and body mass index (BMI) groups with proinflamma…
View article: Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients Open
Background:Physical activity and obesity are well-established factors of colorectal cancer risk and prognosis. Here, we investigate associations of individual and combined physical activity and body mass index (BMI) groups with proinflamma…
View article: Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study
Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study Open
Background: Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cance…
View article: Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients Open
Background: Physical activity and obesity are well-established factors of colorectal cancer risk and prognosis. Here, we investigate associations of individual and combined physical activity and body mass index (BMI) groups with proinflamm…
View article: Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study
Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study Open
Background: Cell-to-cell adhesion and angiogenesis are hallmarks of cancer. No studies have examined associations of adhesion molecules and angiogenesis biomarkers with clinical outcomes in colorectal cancer. Methods: In presurgery serum f…
View article: Differences in gut microbiome abundances and diversity by physical activity levels and BMI among patients with colorectal cancer
Differences in gut microbiome abundances and diversity by physical activity levels and BMI among patients with colorectal cancer Open
We investigated associations of physical activity, BMI, and combinations of physical activity levels/BMI with gut microbiome diversity and differential abundances among colorectal cancer patients. Pre-surgery stool samples from 179 colorec…
View article: Differences in gut microbiome abundances and diversity by physical activity levels and BMI among patients with colorectal cancer
Differences in gut microbiome abundances and diversity by physical activity levels and BMI among patients with colorectal cancer Open
We investigated associations of physical activity, BMI, and combinations of physical activity levels/BMI with gut microbiome diversity and differential abundances among colorectal cancer patients. Pre-surgery stool samples from 179 colorec…
View article: Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients.
Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients. Open
Associations of energy balance components, including physical activity and obesity, with colorectal cancer risk and mortality are well established. However, the gut microbiome has not been investigated as underlying mechanism. We investiga…
View article: The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study
The Use of Human Serum Samples to Study Malignant Transformation: A Pilot Study Open
Obesity and excess adiposity account for approximately 20% of all cancer cases; however, biomarkers of risk remain to be elucidated. While fibroblast growth factor-2 (FGF2) is emerging as an attractive candidate biomarker for visceral adip…
View article: Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients
Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients Open
Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-s…
View article: Multi-omics Analysis Reveals Adipose–tumor Crosstalk in Patients with Colorectal Cancer
Multi-omics Analysis Reveals Adipose–tumor Crosstalk in Patients with Colorectal Cancer Open
Obesity and obesity-driven cancer rates are continuing to rise worldwide. We hypothesize that adipocyte–colonocyte interactions are a key driver of obesity-associated cancers. To understand the clinical relevance of visceral adipose tissue…
View article: One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study
One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study Open
B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and an…
View article: Inflammation‐ and angiogenesis‐related biomarkers are correlated with cancer‐related fatigue in colorectal cancer patients: Results from the ColoCare Study
Inflammation‐ and angiogenesis‐related biomarkers are correlated with cancer‐related fatigue in colorectal cancer patients: Results from the ColoCare Study Open
Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fa…
View article: Gut microbial community diversity is associated with systemic vascular endothelial growth factor A levels among colorectal cancer patients
Gut microbial community diversity is associated with systemic vascular endothelial growth factor A levels among colorectal cancer patients Open
Introduction: Dysbiosis in the gut microbiota and activation of the angiogenic switch in the tumor microenvironment contribute to colorectal carcinogenesis. Methods: Analyses of baseline fecal samples via 16S rRNA gene sequencing, and eval…