Chuanrui Xu
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View article: Bmi1 represses HLF to drive the formation and development of intrahepatic cholangiocarcinoma
Bmi1 represses HLF to drive the formation and development of intrahepatic cholangiocarcinoma Open
These findings revealed the molecular mechanism through which Bmi1 promotes ICC formation and development and uncovered the role of HLF as a tumour suppressor in ICC.
View article: SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL Open
Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular mechanisms…
View article: Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy
Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy Open
BACKGROUND Adenoma detection rate (ADR), a key colonoscopy quality metric, varies with patient demographics and procedural factors. AIM To identify independent predictors of ≥ 25% ADR, develop a risk model, and propose withdrawal durations…
View article: SPP1 <sup>+</sup> Macrophages promote the growth and metastasis of intrahepatic cholangiocarcinoma via OSM and THBS1 signaling
SPP1 <sup>+</sup> Macrophages promote the growth and metastasis of intrahepatic cholangiocarcinoma via OSM and THBS1 signaling Open
Background & Aims Tumor-associated macrophages (TAMs) are abundant in intrahepatic cholangiocarcinoma (ICC), correlate with poor prognosis, but their spatiotemporal behavior and non-immune-suppressive roles in ICC progression remain unclea…
View article: A Difluorinated Derivative of ARC-111 Suppresses Intrahepatic Cholangiocarcinoma Growth via Targeting Topoisomerase I
A Difluorinated Derivative of ARC-111 Suppresses Intrahepatic Cholangiocarcinoma Growth via Targeting Topoisomerase I Open
Intrahepatic cholangiocarcinoma (ICC) has limited treatment options and a poor prognosis. Thus, novel therapeutics are urgently needed. Topoisomerase I (Top I), an essential DNA regulatory enzyme, is commonly upregulated in malignancies an…
View article: Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice
Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice Open
Introduction Accumulating evidence indicates that antioxidants promote tumor growth and metastasis after tumor onset in several cancer types. However, whether antioxidants prevent or accelerate hepatic tumorigenesis during steatosis remain…
View article: Bmi1 represses HLF to drive the formation and development of intrahepatic cholangiocarcinoma
Bmi1 represses HLF to drive the formation and development of intrahepatic cholangiocarcinoma Open
Background Intrahepatic cholangiocarcinoma (ICC) is the second most prevalent type of primary liver cancer and lacks effective targeted therapy. Previously, we reported that B-cell-specific Moloney murine leukemia virus insertion site 1 (B…
View article: Optimization of immunoturbidimetric assay system enhanced by β2-microglobulin latex
Optimization of immunoturbidimetric assay system enhanced by β2-microglobulin latex Open
In this study, three-factor and three-level orthogonal experiment was used to optimize the detection system of clinical renal function marker β2-microglobulin latex enhanced immune turbidity, so as to prepare a detection system with a wide…
View article: Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis Open
Bmi1 is a polycomb group proto-oncogene that has been implicated in multiple tumor types. However, its role in hepatocellular carcinoma (HCC) development has not been well studied. In this article, we report that Bmi1 is overexpressed in h…
View article: Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis Open
Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
View article: Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis Open
Bmi1 is a polycomb group proto-oncogene that has been implicated in multiple tumor types. However, its role in hepatocellular carcinoma (HCC) development has not been well studied. In this article, we report that Bmi1 is overexpressed in h…
View article: Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis Open
Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
View article: Data from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
Data from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis Open
Activation of c-Met signaling and β-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated β-catenin can cooperate with c-Met to induce liver cancer formation in a mouse…
View article: Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis Open
Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
View article: Data from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
Data from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis Open
Activation of c-Met signaling and β-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated β-catenin can cooperate with c-Met to induce liver cancer formation in a mouse…
View article: Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis Open
Supplementary Figures 1-4 from Role of Cyclin D1 as a Mediator of c-Met– and β-Catenin–Induced Hepatocarcinogenesis
View article: microRNA-203 functions as a natural Ras inhibitor in hepatocellular carcinoma.
microRNA-203 functions as a natural Ras inhibitor in hepatocellular carcinoma. Open
microRNA-203 (miR203) plays an important role in the formation and development of multiple types of cancers. However, its role in hepatic carcinogenesis has not been well studied. Mitogen-activated protein kinase signaling is known to be a…
View article: Integrating cell interaction with transcription factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma
Integrating cell interaction with transcription factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma Open
Objective: The efficacy of immunotherapy for cholangiocarcinoma (CCA) is blocked by a high degree of tumor heterogeneity. Cell communication contributes to heterogeneity in the tumor microenvironment. This study aimed to explore critical c…
View article: Glioma Shapes Blood–Brain Barrier Integrity and Remodels the Tumor Microenvironment: Links with Clinical Features and Prognosis
Glioma Shapes Blood–Brain Barrier Integrity and Remodels the Tumor Microenvironment: Links with Clinical Features and Prognosis Open
Background: The presence of the blood–brain barrier (BBB) uniquely distinguishes the brain from other organs, and various brain pathologies, including cancer, can disrupt or breach the BBB. The specific implications of BBB alterations in g…
View article: Integrating cell interaction with transcript factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma
Integrating cell interaction with transcript factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma Open
Background The efficacy of immunotherapy in cholangiocarcinoma (CCA) is blocked by its high degree of tumor heterogeneity. Methods We constructed empirical Bayes and Markov random field models to calculate transcription factors, interactio…
View article: Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression
Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression Open
Background and Aims Intrahepatic cholangiocarcinoma (ICC) is not fully investigated, and how stromal cells contribute to ICC formation is poorly understood. We aimed to uncover ICC origin, cellular heterogeneity, and critical modulators du…
View article: Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression
Resveratrol Attenuates High-Fat Diet–Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression Open
Resveratrol (RES), a natural polyphenol phytoalexin, has been reported to attenuate nonalcoholic fatty liver disease (NAFLD). However, its roles on protection of liver from lipotoxicity and underlying mechanism are not fully understood. In…
View article: Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma
Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma Open
Efficacy of immunotherapy in hepatocellular carcinoma (HCC) is blocked by its high degree of inter‐ and intra‐tumor heterogeneity and immunosuppressive tumor microenvironment. However, the correlation between tumor heterogeneity and immuno…