Explanipedia

Seismic Performance and Collapse Fragility of a 765 kV Transmission Tower–Line System Open

Guodong Shao, Xiao Cong, Min Zhu, Chaoqun Ma, Shaoyuan Zhang · 2025

Based on a real-world project in Pakistan, this study investigates the seismic performance and collapse fragility of a 765 kV transmission tower–line system. A refined finite element model, incorporating three towers and four conductor spa…

Prevalence of histopathological subtypes associated with steroid-resistant nephrotic syndrome in children: a systematic review and meta-analysis Open

Sen Lin, Shanshan Zheng, Wei Dong, Yangyang Tian, Chaoqun Ma , et al. · 2025

Background Steroid-resistant nephrotic syndrome (SRNS) in children is associated with various histopathological subtypes;however, the prevalence of these subtypes remains insufficiently defined. These subtypes often demonstrate variable re…

TIP-seq: A Single-cell Multiomics Approach for Simultaneous Transcriptome and Intracellular Protein Profiling Open

Yingying Xue, Jingyu Qi, Guangting Xie, Ming‐Sheng Wang, Wenhua Xu , et al. · 2025

Single-cell multiomics technologies have significantly advanced our understanding of cellular heterogeneity; however, the concurrent profiling of mRNA transcripts and target proteins continues to pose a substantial challenge. To bridge the…

Prognostic and immunological role of RHEBL1 in pan-cancer: a target for survival and immunotherapy Open

Yue Chen, Xiao Feng, Xiuxian Yin, Yi Nan, Zhao Ya , et al. · 2025

Correlation analysis of Hashimoto’s thyroiditis with papillary thyroid carcinoma occurrence and its central lymph node metastasis: a single center experience Open

Kang Sun, Xiaoming Wang, Dexuan Chen, Chaoqun Ma · 2025

Purpose This study investigates the clinicopathological characteristics of papillary thyroid carcinoma (PTC) with coexisting Hashimoto’s thyroiditis (HT) and further explores the risk factors for central lymph node metastasis (CLNM) in PTC…

Left-lateral decubitus jackknife position for laparoscopic resection of right posterior liver tumors: A safe and effective approach Open

Xiaohan Kong, Zheyu Niu, Heng Wang, Meng Liu, Chaoqun Ma , et al. · 2025

Laparoscopic partial hepatectomy in LDJP for hepatic VI/VII tumor safe and feasible. Reduces operative time, blood loss, transfusion requirement, improving outcomes.

Identification of gastric cancer subtypes based on disulfidptosis-related genes: GPC3 as a novel biomarker for prognosis prediction Open

Nan Yi, Xiuxian Yin, Feng Xiao, Ming Ren, Chaoqun Ma · 2024

Zinc finger 4 negatively controls the transcriptional activator Fzf1 in <i>Saccharomyces cerevisiae</i> Open

Ying Du, Chaoqun Ma, Stanley A. Moore, Wei Xiao · 2024

Fzf1 is a Saccharomyces cerevisiae transcription factor containing five zinc fingers (ZFs). It regulates the expression of at least five downstream genes, including SSU1 , YHB1 , DDI2/ 3, and YNR064c , by recognizing a consensus sequence, …

Perianal tuberculous ulcer with active pulmonary, intestinal and orificial tuberculosis: A case report Open

Bao Yuan, Chaoqun Ma · 2024

BACKGROUND Orificial tuberculosis is a rare type of tuberculosis, which is easy to be misdiagnosed, and can cause great damage to the perianal skin and mucosa. Early diagnosis can avoid further erosion of the perianal muscle tissue by tube…

Prognostic model development and clinical correlation of eight key genes in skin cutaneous melanoma Open

Chaoqun Ma, Ling Xie · 2024

Integrative analysis of bioinformatics and machine learning to identify cuprotosis-related biomarkers and immunological characteristics in heart failure Open

Dingyuan Tu, Qiang Xu, Yanmin Luan, Jie Sun, Xiaoli Zuo , et al. · 2024

Backgrounds Cuprotosis is a newly discovered programmed cell death by modulating tricarboxylic acid cycle. Emerging evidence showed that cuprotosis-related genes (CRGs) are implicated in the occurrence and progression of multiple diseases.…

Correction: Exploring the association between triglyceride-glucose index and thyroid function Open

Hui Cheng, Yanyan Hu, Haoran Zhao, Guowei Zhou, Gaoyuan Wang , et al. · 2024

Mendelian randomization suggests a causal relationship between gut dysbiosis and thyroid cancer Open

Feng Zhu, Pengpeng Zhang, Ying Liu, Chongchan Bao, Dong Qian , et al. · 2023

Background Alterations in gut microbiota composition and function have been linked to the development and progression of thyroid cancer (TC). However, the exact nature of the causal relationship between them remains uncertain. Methods A bi…

Exploring the association between triglyceride-glucose index and thyroid function Open

Hui Cheng, Yanyan Hu, H. Zhao, Guowei Zhou, Gaoyuan Wang , et al. · 2023

Synergistic Enhancement of Woven Copper Wires with Graphene Foams for High Thermal Conductivity of Carbon Fiber Laminated Composites Open

Lu Ni, Xinyang Sun, Jiangang Zhang, Chaoqun Ma, Chang Liu , et al. · 2023

Enhancing thermal conductivity of carbon fiber laminated composites (CFRP) in out-of-plane directions without sacrificing mechanical properties is still challenging for fabrication of high-performance composites with structural and functio…

Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease Open

Shengjie Li, Shanshan Zheng, Jiao Li, Sen Lin, Hao Li , et al. · 2023

Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive de…

Clinical plasma cells-related genes to aid therapy in colon cancer Open

Qi Zhang, Xiao Feng, Mingming Zhang, Wenjing Sun, Yuqing Zhai , et al. · 2023

The tumor immune microenvironment (TIME) of colon cancer (CC) has been associated with extensive immune cell infiltration (IMI). Increasing evidence demonstrated that plasma cells (PC) have an extremely important role in advance of antitum…

Prediction of small molecule drug-miRNA associations based on GNNs and CNNs Open

Zheyu Niu, Xin Gao, Zhaozhi Xia, Shuchao Zhao, Hongrui Sun , et al. · 2023

MicroRNAs (miRNAs) play a crucial role in various biological processes and human diseases, and are considered as therapeutic targets for small molecules (SMs). Due to the time-consuming and expensive biological experiments required to vali…

Identification of m7G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure Open

Chaoqun Ma, Dingyuan Tu, Qiang Xu, Yan Wu, Xiaowei Song , et al. · 2023

Clinical Plasma Cells-related Genes to Aid Therapy in Colon Cancer Open

Qi Zhang, Xiao Feng, Mingming Zhang, Wenjing Sun, Yuqing Zhai , et al. · 2023

Tumor immune microenvironment (TIME) of colon cancer (CC) shows quite a lot immune cell infiltration (IMI), and have been identified to be extensively drawn into the evolution of CC. Accumulated evidence demonstrated that plasma cells (PC)…

Identification of hub genes and transcription factor regulatory network for heart failure using RNA-seq data and robust rank aggregation analysis Open

Dingyuan Tu, Chaoqun Ma, Zhenyu Zeng, Qiang Xu, Zhifu Guo , et al. · 2022

Background Heart failure (HF) is the end stage of various cardiovascular diseases with a high mortality rate. Novel diagnostic and therapeutic biomarkers for HF are urgently required. Our research aims to identify HF-related hub genes and …

Potential prognosis index for m6A-related mRNA in cholangiocarcinoma Open

Huaqiang Zhu, Haini Zhao, Jianlu Wang, Shuchao Zhao, Chaoqun Ma , et al. · 2022

The Association Between Serum Palmitic Acid and Thyroid Function Open

Guowei Zhou, Yumeng Xu, Yuqing Zhai, Zhen Gong, Kun Xu , et al. · 2022

Aim Emerging evidence indicates that palmitic acid (PA) can regulate the progression and development of many diseases. However, the studies examining the association between PA and thyroid function remain sparse. We aimed to investigate th…

Association Between Red Blood Cell Distribution Width and Thyroid Function Open

Guowei Zhou, Yueqin Ai, Song Guo, Quan Chen, Xiao Feng , et al. · 2022

Aim Red blood cell distribution width (RDW) is an important parameter with broad biological implications. However, the study investigating the association between RDW and thyroid function remains sparse and inconsistent. We aimed to invest…

Yanghe Decoction Suppresses the Experimental Autoimmune Thyroiditis in Rats by Improving NLRP3 Inflammasome and Immune Dysregulation Open

Bing’e Ma, Dexuan Chen, Yangjing Liu, Zhengping Zhao, Jianhua Wang , et al. · 2021

Inflammation is an important contributor to autoimmune thyroiditis. Yanghe decoction (YH) is a traditional Chinese herbal formulation which has various anti-inflammatory effects. It has been used for the treatment of autoimmune diseases su…

ARV-825-induced BRD4 protein degradation as a therapy for thyroid carcinoma Open

Ling He, Chen Chen, Guoyu Gao, Kun Xu, Chaoqun Ma · 2020

Bromodomain-containing protein 4 (BRD4) is overexpressed in thyroid carcinoma, represents as an important therapeutic target. ARV-825 is a novel cereblon-based PROTAC (Proteolysis Targeting Chsimera) compound. It can induce fast and sustai…

An HBV-encoded miRNA activates innate immunity to restrict HBV replication Open

Xiaoqing Zhao, Lu Sun, Ting Mu, Jianying Yi, Chaoqun Ma , et al. · 2019

We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remain…

Silencing protein kinase C ζ by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation Open

Shihu Zhang, Yiyang Zhang, Qing Cheng, Chaoqun Ma, Guanwen Gong , et al. · 2017

Developing novel strategies against human colorectal cancer (CRC) cells is needed. Activation of AMP-activated protein kinase (AMPK) could possibly inhibit CRC cells. Protein kinase C ζ (PKCζ) is an AMPK negative regulator. Here we found t…

Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo Open

Huaqiang Zhu, Jinben Ma, Xie Song, Hengjun Gao, Chaoqun Ma , et al. · 2016

Metformin, an oral biguanide drug used to treat type 2 diabetes, has displayed anticancer activities in several types of cancer cells. The combination of gemcitabine and cisplatin is the standard chemotherapy regimen for cholangiocarcinoma…

miR-1299 suppresses cell proliferation of hepatocellular carcinoma (HCC) by targeting CDK6 Open

Huaqiang Zhu, Guangchuan Wang, Xu Zhou, Xie Song, Hengjun Gao , et al. · 2016

microRNA (miRNA) plays critical role in HCC initiation and development, many miRNAs have been reported to regulate HCC progression. In this study, we studied the role of miR-1299 in cell proliferation of HCC. We found miR-1299 was signific…

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