Explanipedia

Microfluidic nano-plasmonic imaging platform for purification- and label-free single small extracellular vesicle characterization Open

Omid Mohsen Daraei, Avinash Kumar Singh, Saswat Mohapatra, Mohammad Sadman Mallick, Abhay Kotnala , et al. · 2025

Microfluidic Nano-Plasmonic Imaging Platform for Purification- and Label-Free Single Small Extracellular Vesicle Counting Open

Omid Mohsen Daraei, Avinash Kumar Singh, Saswat Mohapatra, Mohammad Sadman Mallick, Abhay Kotnala , et al. · 2025

Tumor-derived circulating small extracellular vesicles (sEVs) is a promising non-invasive biomarker for disease diagnosis. However, their quantitative detection remains challenging due to their small size and the complexity of blood plasma…

Author Correction: Plasmonic nano-aperture label-free imaging of single small extracellular vesicles for cancer detection Open

Nareg Ohannesian, Mohammad Sadman Mallick, Jianzhong He, Yawei Qiao, Nan Li , et al. · 2024

In the original version of this article, there was an error in the Results and discussion section, which read 'Using a cutoff of 70 (3.5 ASC/µl), the post-wash sEV counts for all CPP samples (N = 205) were above this threshold except for o…

Plasmonic nano-aperture label-free imaging of single small extracellular vesicles for cancer detection Open

Nareg Ohannesian, Mohammad Sadman Mallick, Jianzhong He, Yawei Qiao, Nan Li , et al. · 2024

Background Small extracellular vesicle (sEV) analysis can potentially improve cancer detection and diagnostics. However, this potential has been constrained by insufficient sensitivity, dynamic range, and the need for complex labeling. Met…

Single‐Exosome Counting and 3D, Subdiffraction Limit Localization Using Dynamic Plasmonic Nanoaperture Label‐Free Imaging Open

Mohammad Sadman Mallick, Ibrahim Misbah, Nareg Ohannesian, Wei‐Chuan Shih · 2023

Blood‐circulating exosomes as a disease biomarker have great potential in clinical applications as they contain molecular information about their parental cells. However, label‐free characterization of exosomes is challenging due to their …

Progressive and instantaneous nature of lithium nucleation discovered by dynamic and operando imaging Open

Guangxia Feng, Yaping Shi, Hao Jia, Samprash Risal, Yang Xu , et al. · 2023

The understanding of lithium (Li) nucleation and growth is important to design better electrodes for high-performance batteries. However, the study of Li nucleation process is still limited because of the lack of imaging tools that can pro…

Exploring the Synergy of Radiative Coupling and Substrate Undercut in Arrayed Gold Nanodisks for Economical, Ultra-Sensitive Label-Free Biosensing Open

Ibrahim Misbah, Nareg Ohannesian, Yawei Qiao, Steven H. Lin, Wei‐Chuan Shih · 2021

We report radiatively coupled arrayed gold nanodisks on invisible substrate (AGNIS) as a cost-effective, high-performance platform for nanoplasmonic biosensing. By substrate undercut, the electric field distribution around the nanodisks ha…

Guest Editorial Introduction to JSTQE Issue on Nanobiophotonics Open

Ilko K. Ilev, Andrea M. Armani, James W. Tunnell, Beop‐Min Kim, Wei‐Chuan Shih , et al. · 2021

The papers in this special section focus on nanobiophotonics. This is an emerging field of modern science and biomedical nanotechnology. This new field continues to vastly expand with state-of-the-art developments across the entire spectru…

Nanoporous Metals: From Plasmonic Properties to Applications in Enhanced Spectroscopy and Photocatalysis Open

Alemayehu Nana Koya, Xiangchao Zhu, Nareg Ohannesian, Ahmet Ali Yanik, Alessandro Alabastri , et al. · 2021

The field of plasmonics is capable of enabling interesting applications in different wavelength ranges, spanning from the ultraviolet up to the infrared. The choice of plasmonic material and how the material is nanostructured has significa…

Directed Concentrating of Micro-/Nanoparticles via Near-Infrared Laser Generated Plasmonic Microbubbles Open

Nareg Ohannesian, Jingting Li, Ibrahim Misbah, Fusheng Zhao, Wei‐Chuan Shih · 2020

Directed concentrating of micro- and nanoparticles via laser-generated plasmonic microbubbles in a liquid environment is an emerging technology. For effective heating, visible light has been primarily employed in existing demonstrations. I…

Optically Tunable Tin Oxide-Coated Hollow Gold–Silver Nanorattles for Use in Solar-Driven Applications Open

Chien‐Hung Li, Orawan Khantamat, Tingting Liu, Md Masud Parvez Arnob, Lin Li , et al. · 2020

Core@shell metal nanoparticles have emerged as promising photocatalysts because of their strong and tunable plasmonic properties; however, marked improvements in photocatalytic efficiency are needed if these materials are to be widely used…

Mid-Infrared Laser Spectroscopy Detection and Quantification of Explosives in Soils Using Multivariate Analysis and Artificial Intelligence Open

Leonardo C. Pacheco‐Londoño, Eric Warren, Nataly J. Galán‐Freyle, Reynaldo Villarreal-González, Joaquin Aparicio , et al. · 2020

A tunable quantum cascade laser (QCL) spectrometer was used to develop methods for detecting and quantifying high explosives (HE) in soil based on multivariate analysis (MVA) and artificial intelligence (AI). For quantification, mixes of 2…

Mid-infrared Laser Spectroscopy Detection and Quantification of Explosives in Soils Using Multivariate Analysis and Artificial Intelligence Open

Leonardo C. Pacheco‐Londoño, Eric Warren, Nataly J. Galán‐Freyle, Reynaldo Villarreal-González, Joaquin Aparicio , et al. · 2020

A tunable quantum cascade laser (QCL) spectrometer was used to develop methods for detecting and quantifying high explosives (HE) in soil based on multivariate analysis (MVA) and artificial intelligence (AI). For quantification, mixes of 2…

Commercial and emerging technologies for cancer diagnosis and prognosis based on circulating tumor exosomes Open

Nareg Ohannesian, Loku Gunawardhana, Ibrahim Misbah, Mohsen Rakhshandehroo, Steven H. Lin , et al. · 2020

Exosomes are nano-sized extracellular vesicles excreted by mammalian cells that circulate freely in the bloodstream of living organisms. Exosomes have a lipid bilayer that encloses genetic material used in intracellular communication (e.g.…

Directed assembly and concentrating of micro/nanoparticles, cells, and vesicles via low-power near-infrared laser generated plasmonic microbubbles Open

Nareg Ohannesian, Jingting Li, Ibrahim Misbah, Fusheng Zhao, Wei‐Chuan Shih · 2020

Directed assembly and concentrating of micro- and nanoparticles via laser generated plasmonic microbubbles in a liquid environment is an emerging technology. For effective heating, visible light has been primarily employed in existing demo…

Single red blood cell analysis reveals elevated hemoglobin in poikilocytes Open

Suet Man Tsui, Rafay Ahmed, Noreen Amjad, Irfan Ahmed, Jingwei Yang , et al. · 2020

Abnormally shaped red blood cells (RBCs), called poikilocytes, can cause anemia. At present, the biochemical abnormalities in poikilocytes are not well understood. Normal RBCs and poikilocytes were analyzed using whole-blood and single-cel…

Taiwanese planning law : a historical review and comparison with Hong Kong Open

Wei‐Chuan Shih · 2019

This thesis compares the evolution of urban planning systems and related laws that operate within Taiwan and Hong Kong. By conducting a historic review, this thesis studies how planning laws and urban plans have been made, shaped and writt…

Antimicrobial Photodynamic Effects Using Coatings Based on Metal Nanoparticles (Ag, Au) Open

Elena S. Tuchina, G. A. Gvozdev, I. D. Kosobudskiy, Wei‐Chuan Shih, Valery V. Tuchin · 2019

Photothermal generation of programmable microbubble array on nanoporous gold disks Open

Li Jingting, Fusheng Zhao, Yu Deng, Dong Liu, Chia‐Hung Chen , et al. · 2018

We present a novel technique to generate microbubbles photothermally by continuous-wave laser irradiation of nanoporous gold disk (NPGD) array covered microfluidic channels. When a single laser spot is focused on the NPGDs, a microbubble c…

Mitigating fringing in discrete frequency infrared imaging using time-delayed integration Open

Shihao Ran, Sebastian Berisha, Rupali Mankar, Wei‐Chuan Shih, David Mayerich · 2018

Infrared (IR) spectroscopic microscopes provide the potential for label-free quantitative molecular imaging of biological samples, which can be used to aid in histology, forensics, and pharmaceutical analysis. Most IR imaging systems use b…

Plasmonic nanoparticle-based expansion microscopy with surface-enhanced Raman and dark-field spectroscopic imaging Open

Camille Artur, Tasha Womack, Fusheng Zhao, Jason L. Eriksen, David Mayerich , et al. · 2018

Fluorescence-based expansion microscopy (ExM) is a new technique which can yield nanoscale resolution of biological specimen on a conventional fluorescence microscope through physical sample expansion up to 20 times its original dimensions…

MRS volume 43 issue 1 Cover and Front matter Open

Gary L. Messing, Susmita Bose, J. Eckert, Linda S. Schadler, Prachi Patel , et al. · 2018

Nanoporous metals by alloy corrosion: Bioanalytical and biomedical applications Open

Erkin Şeker, Wei‐Chuan Shih, Keith J. Stine · 2018

Hyperspectral expansion microscopy with surface-enhanced Raman and dark-field scattering Open

Camille Artur, Tasha Womack, Fusheng Zhao, Jason L. Eriksen, David Mayerich , et al. · 2018

Expansion microscopy (ExM) is a new technique which can yield nanoscale resolution of biological specimen on a conventional fluorescence microscope through physical expansion up to 20 times its original dimensions while preserving structur…

Open-source do-it-yourself multi-color fluorescence smartphone microscopy Open

Y. S. Sung, Fernando Campa, Wei‐Chuan Shih · 2017

Fluorescence microscopy is an important technique for cellular and microbiological investigations. Translating this technique onto a smartphone can enable particularly powerful applications such as on-site analysis, on-demand monitoring, a…

3D Plasmonic Nanoarchitecture As an Emerging Biosensing Platform Open

Md Masud Parvez Arnob, Wei‐Chuan Shih · 2017

Propagating & localized surface plasmon resonanceRecent advances in plasmonics of coinage metals have attracted significant interest in the biosensing community [1,2].Surface plasmon resonance refers to the oscillation of conduction band e…

Nanoporous Gold Nanocomposites as a Versatile Platform for Plasmonic Engineering and Sensing Open

Fusheng Zhao, Jianbo Zeng, Wei‐Chuan Shih · 2017

Plasmonic metal nanostructures have shown great potential in sensing applications. Among various materials and structures, monolithic nanoporous gold disks (NPGD) have several unique features such as three-dimensional (3D) porous network, …

3-Dimensional Plasmonic Substrates Based on Chicken Eggshell Bio-Templates for SERS-Based Bio-Sensing Open

Md Masud Parvez Arnob, Wei‐Chuan Shih · 2017

A simple technique is presented to fabricate stable and reproducible plasmonic substrates using chicken eggshell as bio-templates, an otherwise everyday waste material. The 3-dimensional (3D) submicron features on the outer shell (OS), inn…

Tissue Engineering: Effective Light Directed Assembly of Building Blocks with Microscale Control (Small 24/2017) Open

Ngoc‐Duy Dinh, Rongcong Luo, Maria Tankeh Asuncion Christine, Weikang Nicholas Lin, Wei‐Chuan Shih , et al. · 2017

In article number 1700684, Chia-Hung Chen, and co-workers, introduce a novel light assembly method on the microscale by suspending gold nanorods (GNRs), as photothermal transducers, in a fluidic medium to induce thermoplasmonic convections…

Fabrication of multipoint side-firing optical fiber by laser micro-ablation Open

Hoang Nguyen, Md Masud Parvez Arnob, Aaron T. Becker, J. C. Wolfe, Matthew Hogan , et al. · 2017

A multipoint, side-firing design enables an optical fiber to output light at multiple desired locations along the fiber body. This provides advantages over traditional end-to-end fibers, especially in applications requiring fiber bundles s…

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