Chuanlai Xu
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View article: Enhanced Lateral Flow Immunoassay for Pesticide Paraquat Based on Combining Magnetite and Gold Nanoparticles
Enhanced Lateral Flow Immunoassay for Pesticide Paraquat Based on Combining Magnetite and Gold Nanoparticles Open
A lateral flow immunoassay (LFIA) utilizing two types of marker conjugates—magnetite nanoparticles (MNPs) with specific antibodies and gold nanoparticles (GNPs) with anti-species antibodies—was proposed and realized for the detection of th…
View article: Highly Sensitive Lateral Flow Immunoassay for Clenbuterol and Structurally Similar Beta2-Agonists in Meat
Highly Sensitive Lateral Flow Immunoassay for Clenbuterol and Structurally Similar Beta2-Agonists in Meat Open
Beta-agonists are growth promoters sparking considerable interest in animal husbandry. However, their numerous negative effects on health have led to a number of restrictions on their presence in agricultural products, which differ dependi…
View article: A Knowledge-Driven Diffusion Policy for End-to-End Autonomous Driving Based on Expert Routing
A Knowledge-Driven Diffusion Policy for End-to-End Autonomous Driving Based on Expert Routing Open
End-to-end autonomous driving remains constrained by the difficulty of producing adaptive, robust, and interpretable decision-making across diverse scenarios. Existing methods often collapse diverse driving behaviors, lack long-horizon con…
View article: Optimization by an orthogonal array design of deep hydrolysis of bovine milk whey proteins and caseins to reduce allergenicity
Optimization by an orthogonal array design of deep hydrolysis of bovine milk whey proteins and caseins to reduce allergenicity Open
Bovine milk (BM) is a common nutrient-rich food, but also a potential allergen for infants with milk allergy. In this study, a method for the preparation of deeply hydrolyzed whey proteins or caseins (DH-WP and DH-CN, respectively) was pro…
View article: Towards Human-Centric Autonomous Driving: A Fast-Slow Architecture Integrating Large Language Model Guidance with Reinforcement Learning
Towards Human-Centric Autonomous Driving: A Fast-Slow Architecture Integrating Large Language Model Guidance with Reinforcement Learning Open
Autonomous driving has made significant strides through data-driven techniques, achieving robust performance in standardized tasks. However, existing methods frequently overlook user-specific preferences, offering limited scope for interac…
View article: Opportunities and Challenges for Nanomaterials as Vaccine Adjuvants
Opportunities and Challenges for Nanomaterials as Vaccine Adjuvants Open
Adjuvants, as a critical component of vaccines, are capable of eliciting more robust and sustained immune responses. Nanomaterials have shown unique advantages and broad application prospects in adjuvant development due to their high adjus…
View article: Enhancing lateral flow immunoassay performance for cardiac troponin I detection with pore-size tailored silica nanoparticles and smartphone-based “AdaptiScan” analysis
Enhancing lateral flow immunoassay performance for cardiac troponin I detection with pore-size tailored silica nanoparticles and smartphone-based “AdaptiScan” analysis Open
The accurate and rapid detection of cardiac troponin I (cTnI) at the point of care is crucial for the timely diagnosis of myocardial infarction (MI). This study introduces an advanced lateral flow immunoassay (LFIA) platform for cTnI detec…
View article: Establishment and Application of Time‐Resolved Fluorescence Strip Method for Biotin Detection in Milk Powder
Establishment and Application of Time‐Resolved Fluorescence Strip Method for Biotin Detection in Milk Powder Open
Biotin can be added to milk powder to achieve recommended daily intake levels. In order to determine whether the actual amount of biotin added in food is consistent with the labeled content, a time‐resolved fluorescence immunochromatograph…
View article: Chiral Gold Nanostructure Monolayers as SERS Substrates for Ultrasensitive Detection of Enantiomer Biomarkers of Alzheimer's Disease
Chiral Gold Nanostructure Monolayers as SERS Substrates for Ultrasensitive Detection of Enantiomer Biomarkers of Alzheimer's Disease Open
The early diagnosis of neurodegenerative diseases, such as Alzheimer's disease (AD), requires the identification of sensitive and specific biomarkers. Detecting chiral molecules at concentrations relevant to disease states remains challeng…
View article: Chiral Gold Nanostructure Monolayers as SERS Substrates for Ultrasensitive Detection of Enantiomer Biomarkers of Alzheimer's Disease
Chiral Gold Nanostructure Monolayers as SERS Substrates for Ultrasensitive Detection of Enantiomer Biomarkers of Alzheimer's Disease Open
The early diagnosis of neurodegenerative diseases, such as Alzheimer's disease (AD), requires the identification of sensitive and specific biomarkers. Detecting chiral molecules at concentrations relevant to disease states remains challeng…
View article: Chiral Bimetallic Pt@Au Octapods with Spiral Four‐Petal Flower‐Like Symmetric Configuration as Sensitive SERS Probes
Chiral Bimetallic Pt@Au Octapods with Spiral Four‐Petal Flower‐Like Symmetric Configuration as Sensitive SERS Probes Open
Here, we synthesized chiral bimetallic Pt@Au octapods by using l / d ‐cysteine–threonine (CT) dipeptide as chiral ligands. These had a distinct spiral four‐petal flower‐like symmetric configuration with a twisted concave morphology on each…
View article: Chiral Bimetallic Pt@Au Octapods with Spiral Four‐Petal Flower‐Like Symmetric Configuration as Sensitive SERS Probes
Chiral Bimetallic Pt@Au Octapods with Spiral Four‐Petal Flower‐Like Symmetric Configuration as Sensitive SERS Probes Open
Here, we synthesized chiral bimetallic Pt@Au octapods by using l / d ‐cysteine–threonine (CT) dipeptide as chiral ligands. These had a distinct spiral four‐petal flower‐like symmetric configuration with a twisted concave morphology on each…
View article: Naringenin inhibits ferroptosis to reduce radiation-induced lung injury: insights from network Pharmacology and molecular docking
Naringenin inhibits ferroptosis to reduce radiation-induced lung injury: insights from network Pharmacology and molecular docking Open
Naringenin alleviates radiation-induced lung damage by inhibiting ferroptosis, with PTGS2 and VCP emerging as potential therapeutic targets.
View article: A Time-Resolved Fluorescent Microsphere Immunochromatographic Assay for Determination of Vitamin B12 in Infant Formula Milk Powder
A Time-Resolved Fluorescent Microsphere Immunochromatographic Assay for Determination of Vitamin B12 in Infant Formula Milk Powder Open
Vitamin B12 (VB12) is an important nutrient, and its quality control in food is crucial. In this study, based on the principle of specific recognition of target analyte by monoclonal antibodies (mAbs), a time-resolved fluorescent microsphe…
View article: Fluorescence Polarization Immunoassay for Rapid, Sensitive Detection of the Herbicide 2,4-Dichlorophenoxyacetic Acid in Juice and Water Samples
Fluorescence Polarization Immunoassay for Rapid, Sensitive Detection of the Herbicide 2,4-Dichlorophenoxyacetic Acid in Juice and Water Samples Open
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the popular herbicides that is widely used in agriculture and can be found in food and water. A rapid and sensitive fluorescence polarization immunoassay (FPIA) was proposed for the detectio…
View article: Improved Catalytic Performance of Lipase Within Hydrogel Microspheres Incorporating L/D‐Co<sub>3</sub>O<sub>4</sub> Nanoparticles
Improved Catalytic Performance of Lipase Within Hydrogel Microspheres Incorporating L/D‐Co<sub>3</sub>O<sub>4</sub> Nanoparticles Open
Lipases have drawn significant attention due to their crucial roles across various industries, including oil processing, food, medicine, and daily chemicals. Nevertheless, their catalytic efficiency is susceptible to fluctuations in extern…
View article: Squaraine‐Linked Magnetic Covalent Organic Framework as a Solid‐Phase Extraction Absorbent to Determine Trace Phenylpyrazoles
Squaraine‐Linked Magnetic Covalent Organic Framework as a Solid‐Phase Extraction Absorbent to Determine Trace Phenylpyrazoles Open
Phenylpyrazoles are widely used pesticides in the food industry. It is highly desirable to develop efficient pre‐treatment and analysis methods to extract and detect phenylpyrazoles in complex food matrices. Herein, the study reports novel…
View article: Chiral Intranasal Nanovaccines as Antivirals for Respiratory Syncytial Virus
Chiral Intranasal Nanovaccines as Antivirals for Respiratory Syncytial Virus Open
This study aimed to develop an intranasal nanovaccine by combining chiral nanoparticles with the RSV pre‐fusion protein (RSV protein) to create L‐nanovaccine (L‐Vac). The results showed that L‐NPs increased antigen attachment in the nasal …
View article: An ultrasensitive strip sensor for rapid detection of African swine fever virus
An ultrasensitive strip sensor for rapid detection of African swine fever virus Open
African swine fever (ASF) is a highly contagious disease caused by the African swine fever virus (ASFV) infecting pigs, which has caused huge economic losses in countries around the world. Currently, there is no effective vaccine, and the …
View article: Emerging trends in chiral inorganic nanomaterials for enantioselective catalysis
Emerging trends in chiral inorganic nanomaterials for enantioselective catalysis Open
Asymmetric transformations and synthesis have garnered considerable interest in recent decades due to the extensive need for chiral organic compounds in biomedical, agrochemical, chemical, and food industries. The field of chiral inorganic…
View article: Tapered chiral nanoparticles as broad-spectrum thermally stable antivirals for SARS-CoV-2 variants
Tapered chiral nanoparticles as broad-spectrum thermally stable antivirals for SARS-CoV-2 variants Open
The incessant mutations of viruses, variable immune responses, and likely emergence of new viral threats necessitate multiple approaches to novel antiviral therapeutics. Furthermore, the new antiviral agents should have broad-spectrum acti…
View article: Modulation by Co (II) Ion of Optical Activities of <i>L</i>/<i>D</i>‐glutathione (GSH)‐modified Chiral Copper Nanoclusters for Sensitive Adenosine Triphosphate Detection
Modulation by Co (II) Ion of Optical Activities of <i>L</i>/<i>D</i>‐glutathione (GSH)‐modified Chiral Copper Nanoclusters for Sensitive Adenosine Triphosphate Detection Open
Chiral nanoscale enantiomers exhibit different biological effects in living systems. However, their chirality effect on the detection sensitivity for chiral biological targets still needs to be explored. Here, we discovered that Co 2+ can …
View article: Ultrasensitive detection of imatinib in human serum using a gold-based paper sensor
Ultrasensitive detection of imatinib in human serum using a gold-based paper sensor Open
Imatinib is the tyrosine kinase inhibitor of choice for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors. However, imatinib has drawbacks such as drug resistance and significant differences in pharmacokinetics …