Chuanlei Wang
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View article: The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer
The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer Open
The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance mechanisms. Novel approaches to overcome these drawbacks comprise the utilization of ionophores and metalli…
View article: Immunotherapy for autoimmune encephalitis
Immunotherapy for autoimmune encephalitis Open
Autoimmune encephalitis (AE) is increasingly recognized as a cause of brain disorders that greatly benefit from immunotherapy. Starting treatment quickly and increasing the use of immunotherapy can lead to better results for AE patients. C…
View article: Gastroesophageal reflux disease as a risk factor for oral cavity and pharyngeal cancer: a Mendelian randomization study
Gastroesophageal reflux disease as a risk factor for oral cavity and pharyngeal cancer: a Mendelian randomization study Open
View article: A Novel Martensitic Stainless Steel Material for CO2 Corrosion Environment
A Novel Martensitic Stainless Steel Material for CO2 Corrosion Environment Open
The novel martensitic stainless steel 13CrU was developed based on 13CrS by adding trace alloying elements, such as Mo, Ni, and Ta. This study compares the mechanical and corrosion resistance properties of the two martensitic stainless ste…
View article: Exploring potential predictive biomarkers through historical perspectives on the evolution of systemic therapies into the emergence of neoadjuvant therapy for the treatment of hepatocellular carcinoma
Exploring potential predictive biomarkers through historical perspectives on the evolution of systemic therapies into the emergence of neoadjuvant therapy for the treatment of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC), a type of liver cancer, ranks as the sixth most prevalent cancer globally and represents the third leading cause of cancer-related deaths. Approximately half of HCC patients miss the opportunity for curative…
View article: The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer
The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer Open
The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance mechanisms. Novel approaches to overcome these drawbacks comprise the utilization of ionophores and metalli…
View article: Endoplasmic reticulum stress and quality control in relation to cisplatin resistance in tumor cells
Endoplasmic reticulum stress and quality control in relation to cisplatin resistance in tumor cells Open
The endoplasmic reticulum (ER) is a crucial organelle that orchestrates key cellular functions like protein folding and lipid biosynthesis. However, it is highly sensitive to disturbances that lead to ER stress. In response, the unfolded p…
View article: Corrosion behavior of Ni-W coatings with and without macroscopic defects under different corrosion conditions
Corrosion behavior of Ni-W coatings with and without macroscopic defects under different corrosion conditions Open
High pressure and high temperature corrosion performance of Ni-W coatings with and without macroscopic defects were investigated successively in live acid at 100 ℃, spent acid and formation water containing CO2&H2S at 160 ℃ by using weight…
View article: Tripartite Evolutionary Game Analysis of a Logistics Service Supply Chain Cooperation Mechanism for Network Freight Platforms
Tripartite Evolutionary Game Analysis of a Logistics Service Supply Chain Cooperation Mechanism for Network Freight Platforms Open
The rapid development of network freight platforms has directly increased the level of social logistics resource collaboration and improved both the efficiency and quality of logistics industry services. As a bilateral platform that connec…
View article: Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis
Radiation enteropathy‐related depression: A neglectable course of disease by gut bacterial dysbiosis Open
Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic–abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial…
View article: Quenching thirst with poison? Paradoxical effect of anticancer drugs
Quenching thirst with poison? Paradoxical effect of anticancer drugs Open
Anticancer drugs have been developed with expectations to provide long-term or at least short-term survival benefits for patients with cancer. Unfortunately, drug therapy tends to provoke malignant biological and clinical behaviours of can…
View article: Assessing the Impact of Gastroesophageal Reflux Disease on the Risk of Oral Cavity and Pharyngeal Cancer Using Mendelian Randomization
Assessing the Impact of Gastroesophageal Reflux Disease on the Risk of Oral Cavity and Pharyngeal Cancer Using Mendelian Randomization Open
Purpose: Previous observational studies have yielded inconsistent findings regarding the relationship between gastroesophageal reflux disease (GERD) and the risk of oral cavity and pharyngeal cancer (OCPC). This study aims to employ Mendel…
View article: From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification
From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification Open
Objective Selecting interventions for patients with solitary hepatocellular carcinoma (HCC) remains a challenge. Despite gross classification being proposed as a potential prognostic predictor, its widespread use has been restricted due to…
View article: Research on sealing performance of special thread of tubing under complex load
Research on sealing performance of special thread of tubing under complex load Open
In order to study the performance of a special threaded joint of a tubing under severe well conditions, a two-dimensional finite element model of this joint was established in the finite element software, and the mechanical properties and …
View article: Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex
Long-term exposure to genistein inhibits the proliferation of gallbladder cancer by downregulating the MCM complex Open
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation of tyrosine kinases such as ERBB2 is the mechanism by which cholecystitis transforms into ga…
View article: Research on Quality Construction of National Logistics Hub in Yangtze River Delta Based on DPSIR Model
Research on Quality Construction of National Logistics Hub in Yangtze River Delta Based on DPSIR Model Open
Under the background of double circulation, the national logistics hub will play an important role of node, hub and platform in the national logistics network. As a national strategy, the integration of Yangtze River Delta matters a lot to…
View article: Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study
Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study Open
Introduction Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on the clinical characteristics, treatment and …
View article: Surgical treatment of a rare case of hepatocellular carcinoma with right atrial metastasis
Surgical treatment of a rare case of hepatocellular carcinoma with right atrial metastasis Open
Rationale: Hepatocellular carcinoma (HCC) with intracavitary metastasis extending to the heart, also known as inferior vena cava (IVC) tumor thrombus, is an extremely rare late-stage disease with no effective treatment. In fact, the median…
View article: Colorectal Cancer Immune Infiltrates: Significance in Patient Prognosis and Immunotherapeutic Efficacy
Colorectal Cancer Immune Infiltrates: Significance in Patient Prognosis and Immunotherapeutic Efficacy Open
Colorectal cancer occurrence and progression involve multiple aspects of host immune deficiencies. In these events, immune cells vary their phenotypes and functions over time, thus enabling the immune microenvironment to be "tumor-inhibiti…
View article: Informatization Development, Structural Evolution and Competitiveness Enhancement of Commerce Logistics
Informatization Development, Structural Evolution and Competitiveness Enhancement of Commerce Logistics Open
View article: Modulation of mitogen-activated protein kinase attenuates sepsis-induced acute lung injury in acute respiratory distress syndrome rats
Modulation of mitogen-activated protein kinase attenuates sepsis-induced acute lung injury in acute respiratory distress syndrome rats Open
Sepsis is the most important predisposing cause inducing acute respiratory distress syndrome (ARDS); however, the mechanism of sepsis leading to the development of ARDS remains to be elucidated. Suppression of the mitogen‑activated protein…
View article: Clinical application of hepatopancreatoduodenectomy in treatment of advanced gallbladder cancer
Clinical application of hepatopancreatoduodenectomy in treatment of advanced gallbladder cancer Open
Gallbladder cancer has many characteristics such as rapid progression, difficult early diagnosis, low R0 resection rate, and poor prognosis. In recent years, extended radical resections including hepatopancreatoduodenectomy (HPD) have been…
View article: Optimal three-dimensional reconstruction for lung cancer tissues
Optimal three-dimensional reconstruction for lung cancer tissues Open
The existing three-dimensional (3D) x-ray reconstruction methods for lung cancer tissue reconstruct the investigated objects based on a series of two-dimensional (2D) image sections and a chosen 3D reconstruction algorithm. However, becaus…
View article: Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis
Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis Open
Purpose . Urothelial carcinoma-associated 1 (UCA1) has been reported to be overexpressed and correlated with progression in various cancers. However, the association between UCA1 expression and some clinicopathological features of digestiv…
View article: Test and Application of Magnetic Survey in Detecting Ancient Wooden Sunken Boats
Test and Application of Magnetic Survey in Detecting Ancient Wooden Sunken Boats Open
There are rich cultural heritages both underwater and in land in China, which is the object concerned by archaeologists and historic researchers, especially the ancient wooden sunken boats containing the past information of old human civli…
View article: Elevated Preoperative Neutrophil-Lymphocyte Ratio Is Associated with Poor Prognosis in Hepatocellular Carcinoma Patients Treated with Liver Transplantation: A Meta-Analysis
Elevated Preoperative Neutrophil-Lymphocyte Ratio Is Associated with Poor Prognosis in Hepatocellular Carcinoma Patients Treated with Liver Transplantation: A Meta-Analysis Open
This study aims to investigate the prognostic value of neutrophil to lymphocyte ratio (NLR) in hepatocellular carcinoma (HCC) patients treated with liver transplantation (LT) through meta-analysis. Relevant articles were sought in PubMed, …