Chuanman Zhou
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View article: NaRaDa: A comprehensive nascent RNA database
NaRaDa: A comprehensive nascent RNA database Open
Nascent RNA-seq is pivotal for elucidating the dynamics and transcriptional regulation of enhancer RNA and protein-coding genes, and for revealing the regulatory linkages between enhancer-gene pairs in diverse physiological and pathologica…
View article: Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels
Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels Open
Two-pore domain potassium channels (K2P) are a large family of “background” channels that allow outward “leak” of potassium ions. The NALCN/UNC80/UNC79 complex is a non-selective channel that allows inward flow of sodium and other cations.…
View article: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate<i>Caenorhabditis elegans</i>Reversal Behavior
The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate<i>Caenorhabditis elegans</i>Reversal Behavior Open
NALCN (Na+ leak channel, non-selective) is a conserved, voltage-insensitive cation channel that regulates resting membrane potential and neuronal excitability. UNC79 and UNC80 are key regulators of the channel function. However, the behavi…
View article: The NALCN regulator UNC-80 functions in a subset of interneurons to affect<i>C. elegans</i>avoidance response to the plant hormone methyl salicylate
The NALCN regulator UNC-80 functions in a subset of interneurons to affect<i>C. elegans</i>avoidance response to the plant hormone methyl salicylate Open
NALCN ( Na + leak c hannel, n on-selective), UNC80 and UNC79 form a non-selective, voltage-independent cation channel complex that affects a broad array of neuronal activities. The molecular and neuronal mechanisms underlying the functions…
View article: Defective Expression of Mitochondrial, Vacuolar H+-ATPase and Histone Genes in a C. elegans Model of SMA
Defective Expression of Mitochondrial, Vacuolar H+-ATPase and Histone Genes in a C. elegans Model of SMA Open
Spinal muscular atrophy (SMA) is a severe motor neuron degenerative disease caused by loss-of-function mutations in the survival motor neuron gene SMN1. It is widely posited that defective gene expression underlies SMA. However, the identi…
View article: RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i>
RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i> Open
A key step in pre-mRNA splicing is the recognition of 3' splicing sites by the U2AF large and small subunits, a process regulated by numerous trans-acting splicing factors. How these trans-acting factors interact with U2AF in vivo is uncle…
View article: RBM-5 modulates U2AF large subunit-dependent alternative splicing in<i>C. elegans</i>
RBM-5 modulates U2AF large subunit-dependent alternative splicing in<i>C. elegans</i> Open
A key step in pre-mRNA splicing is the recognition of 3’ splicing sites by the U2AF large and small subunits, a process regulated by numerous trans -acting splicing factors. How these trans -acting factors interact with U2AF in vivo is unc…
View article: RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i>
RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i> Open
A key step in pre-mRNA splicing is the recognition of 3ʹ splicing sites by the U2AF large and small subunits, a process regulated by numerous trans-acting splicing factors. How these trans-acting factors interact with U2AF in vivo is uncle…
View article: RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i>
RBM-5 modulates U2AF large subunit-dependent alternative splicing in <i>C. elegans</i> Open
A key step in pre-mRNA splicing is the recognition of 3ʹ splicing sites by the U2AF large and small subunits, a process regulated by numerous trans-acting splicing factors. How these trans-acting factors interact with U2AF in vivo is uncle…