Chuanxi Yang
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View article: Correction: Comprehensive analysis of the transcriptome-wide m6A methylome of heart via MeRIP after birth: day 0 vs. day 7
Correction: Comprehensive analysis of the transcriptome-wide m6A methylome of heart via MeRIP after birth: day 0 vs. day 7 Open
[This corrects the article DOI: 10.3389/fcvm.2021.633631.].
View article: How employees can break out of their learning comfort zone in green innovation scenarios: a nudging experiment based on the pressures of sustainable development in China
How employees can break out of their learning comfort zone in green innovation scenarios: a nudging experiment based on the pressures of sustainable development in China Open
The use of nudging tools to motivate employees to actively participate in corporate green innovation has not yet received sufficient attention. Designing and implementing effective nudging strategies to push employees out of their comfort …
View article: Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway Open
Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization (RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti-vascular endothelial growth factor (VEGF) therapy, which is costly …
View article: Scoping review of epigenetics on neurodegenerative diseases: research frontiers and publication status
Scoping review of epigenetics on neurodegenerative diseases: research frontiers and publication status Open
Aims Epigenetics has significantly evolved and emerged as important players in the pathogenesis of neurodegenerative diseases. However, a scientometric synthesis of such changes over time is currently lacking. Methods We conducted a compre…
View article: Erratum to: Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway
Erratum to: Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway Open
The original version of this article (Zhao et al., 2021) unfortunately contained two mistakes.
View article: NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation
NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation Open
BACKGROUND: Heart failure, characterized by cardiac remodeling, is associated with abnormal epigenetic processes and aberrant gene expression. Here, we aimed to elucidate the effects and mechanisms of NAT10 (N-acetyltransferase 10)-mediate…
View article: Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling
Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling Open
Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD), alleviates angiotensin II (AngII)-induced cardiac hypertrophy. However, the specific physiological and pathological role of MrgD is not yet elucidated. …
View article: Trends in worldwide research on cardiac fibrosis over the period 1989–2022: a bibliometric study
Trends in worldwide research on cardiac fibrosis over the period 1989–2022: a bibliometric study Open
Background Cardiac fibrosis is a hallmark of various end-stage cardiovascular diseases (CVDs) and a potent contributor to adverse cardiovascular events. During the past decades, extensive publications on this topic have emerged worldwide, …
View article: Age‐specific differences in hypertension combination management and associated factors influencing treatment choice
Age‐specific differences in hypertension combination management and associated factors influencing treatment choice Open
The current hypertension guideline emphasizes combination therapy, especially single‐pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age g…
View article: The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling Open
Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the w…
View article: Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway Open
Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization (RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti-vascular endothelial growth factor (VEGF) therapy, which is costly …
View article: RETRACTED ARTICLE: METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner
RETRACTED ARTICLE: METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner Open
Myocardial infarction (MI), one of the most severe types of heart attack, exerts a strong negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes. However, the existing therapies do little to improve cardiac r…
View article: Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway Open
These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway, providing new insights for the development of novel therapeutic apparatus in clinical practi…
View article: Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing
Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing Open
Aim Pterygium is a common ocular surface disease, which is affected by a variety of factors. Invasion of the cornea can cause severe vision loss. N6-methyladenosine (m6A) is a common post-transcriptional modification of eukaryotic mRNA, wh…
View article: Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research?
Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research? Open
Background NAT10 (also known as human N-acetyltransferase-like protein) is a critical gene that regulates N4-acetylcytidine formation in RNA, similar to the multiple regulators of N6-methyladenosine. However, the underlying functions and m…
View article: Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction
Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction Open
Pellino1 has been shown to regulate proinflammatory genes by activating the nuclear factor kappa B (NF-κB) and Toll-like receptor (TLR) signaling pathways, which are important in the pathological development of lipopolysaccharide (LPS)-ind…
View article: Comprehensive Analysis of the Transcriptome-Wide m6A Methylome of Heart via MeRIP After Birth: Day 0 vs. Day 7
Comprehensive Analysis of the Transcriptome-Wide m6A Methylome of Heart via MeRIP After Birth: Day 0 vs. Day 7 Open
Aim: To systematically classify the profile of the RNA m6A modification landscape of neonatal heart regeneration. Materials and Methods: Cardiomyocyte proliferation markers were detected via immunostaining. The expression of m6A modificati…
View article: Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells
Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells Open
This study aimed at exploring the gene expression and metabolites among multisite adipose-derived mesenchymal stem cells (ASCs) and investigate the metabolic pathway using a multi-omics analysis. Subcutaneous adipose-derived mesenchymal st…
View article: POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression
POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression Open
Excessive production of visceral adipose is a major risk factor of many diseases. Inhibiting the adipogenesis of mesenchymal stem cells (MSCs) will be an efficient way to block adipose production. We illuminated POU class 2 homeobox associ…
View article: POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression
POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression Open
Excessive production of visceral adipose is a major risk factor of many diseases. Inhibiting the adipogenesis of mesenchymal stem cells (MSCs) will be an efficient way to block adipose production. We illuminated POU class 2 homeobox associ…
View article: Celastrol attenuates arterial and valvular calcification via inhibiting BMP2/Smad1/5 signalling
Celastrol attenuates arterial and valvular calcification via inhibiting BMP2/Smad1/5 signalling Open
Vascular calcification is an important risk factor for the mortality and morbidity in chronic kidney disease (CKD). Unfortunately, until now there is no certain medication targeting vascular calcification in CKD. In this study, we explored…
View article: Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system
Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system Open
As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of …
View article: A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease
A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease Open
Dry eye syndrome induces changes in the metabolic profile of tears, and the trend differs with age. This evidence reveals the relationship between changes in metabolites, symptoms of dry eye syndrome, and age.
View article: Application of Six Sigma for evaluating the analytical quality of tumor marker assays
Application of Six Sigma for evaluating the analytical quality of tumor marker assays Open
Context The results of detection assays for the same specimen are usually quite different in different laboratories or when tested with different detection systems. Objective This study was designed to investigate the value of applying sig…