Chuanyuan Chen
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View article: Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy
Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy Open
Azacitidine (AZA) is a DNA methyltransferase inhibitor and epigenetic modulator that can be an effective agent in combination with chemotherapy for patients with high‐risk acute myeloid leukemia (AML). However, biological factors driving t…
View article: <i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
<i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription Open
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associat…
View article: Additional file 3: of Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds
Additional file 3: of Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds Open
Table S1. Oligonucleotides (oligos) for Cas12a gene synthesis. (XLSX 81 kb)
View article: Highly efficient base editing in <i>Staphylococcus aureus</i> using an engineered CRISPR RNA-guided cytidine deaminase
Highly efficient base editing in <i>Staphylococcus aureus</i> using an engineered CRISPR RNA-guided cytidine deaminase Open
The base editor pnCasSA-BEC enables highly efficient base editing in Staphylococcus aureus.